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33 results for “Strongyloides”
Diagnostic accuracy of a novel enzyme‑linked immunoassay for the detection of IgG and IgG4 against Strongyloides stercoralis based on the recombinant antigens NIE/SsIR.
<p>Background: The diagnosis of strongyloidiasis is challenging. Serological tests are acknowledged to have high sensitivity, but issues due to cross-reactions with other parasites, native parasite antigen supply and intrinsic test variability do occur. Assays based on recombinant antigens could represent an improvement. The aim of this study was to assess the sensitivity and specificity of two novel immunoglobulin (Ig)G and IgG4 enzyme-linked immunosorbent assays (ELISAs) based on the recombinant antigens NIE/SsIR for the diagnosis of strongyloidiasis.</p> <p>Methods: This was a retrospective diagnostic accuracy study. We included serum samples collected from immigrants from strongyloidiasis endemic areas for whom there was a matched result for Strongyloides stercoralis on agar plate culture and/or PCR assay, or a positive microscopy for S. stercoralis larvae. For the included samples, results were also available from an in-house indirect fluorescent antibody test (IFAT) and a commercial (Bordier ELISA; Bordier Affinity Products SA) ELISA. We excluded: (i) samples with insufficient serum volume; (ii) samples from patients treated with ivermectin in the previous 6 months; and (iii) sera from patients for whom only routine coproparasitology was performed after formol–ether concentration, if negative for S. stercoralis larvae. The performance of the novel assays was assessed against: (i) a primary reference standard, with samples classified as negative/positive on the basis of the results of fecal tests; (ii) a composite reference standard (CRS), which also considered patients to be positive who had concordant positive results for the IFAT and Bordier ELISA or with a single “high titer” positive result for the IFAT or Bordier ELISA. Samples with a single positive test, either for the IFAT or Bordier ELISA, at low titer, were considered to be “indeterminate,” and analyses were carried out with and without their inclusion.</p> <p>Results: When assessed against the primary reference standard, the sensitivities of the IgG and IgG4 ELISAs were 92% (95% confidence interval [CI]: 88–97%) and 81% (95% CI: 74–87%), respectively, and the specificities were 91% (95% CI: 88–95%) and 94% (95% CI: 91–97%), respectively. When tested against the CRS, the IgG ELISA performed best, with 78% sensitivity (95% CI: 72–83%) and 98% specificity (95% CI: 96–100%), when a cut-off of 0.675 was applied and the indeterminate samples were excluded from the analysis.</p> <p>Conclusion: The NIE-SsIR IgG ELISA demonstrated better accuracy than the IgG4 assay and was deemed promising particularly for serosurveys in endemic areas.</p>
Fig. 1 Screening flow, testing 1600 FDA compounds against S in Assessment of FDA-approved drugs against StrongyloideS rAtti in vitro and in vivo to identify potentially active drugs against strongyloidiasis
Fig. 1 Screening flow, testing 1600 FDA compounds against S. ratti
Accuracy, acceptability, and feasibility of diagnostic tests for the screening of Strongyloides stercoralis in the field: the ESTRELLA study
<p>Raw data from the diagnostic study ESTRELLA. </p> <p>The primary objective of this study was to estimate the accuracy of five tests - a recombinant antigen- rapid diagnostic test (RDT); a crude antigen-based ELISA (Bordier ELISA); an ELISA based on two recombinant antigens (Strongy Detect ELISA); a modified Baermann method; an in-house real-time PCR for <em>Strongyloides stercoralis</em> infection. Secondary objectives were acceptability and feasibility of use in an endemic area.</p> <p>The study was carried out in remote villages of Ecuador</p>
Efficacy and Safety of Moxidectin Versus Ivermectin Against Strongyloides Stercoralis
ClinicalTrials.gov study NCT04848688. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Efficacy, Safety, and PK of Ascending Dosages of Moxidectin Versus Ivermectin Against Strongyloides Stercoralis
ClinicalTrials.gov study NCT04056325. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Treatment of Strongyloides Infection
ClinicalTrials.gov study NCT03605758. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Patients With Strongyloides Stercoralis Infection
ClinicalTrials.gov study NCT00001245. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Strongyloides Stercoralis Public Health Control in Rwanda
ClinicalTrials.gov study NCT07009613. IPD Sharing: NO. Countries: 1. Publications: 0.
The SsRI/NIE Recombinant Antigen ELISA for the Follow up of Patients Infected by Strongyloides Stercoralis
ClinicalTrials.gov study NCT06308705. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Microarray Analysis of Infective and Noninfective Larvae of Strongyloides stercoralis
GEO Series GSE24735. Strongyloides stercoralis. 4 samples. Type: Expression profiling by array.
Strongyloides Stercoralis in Bone Marrow Transplant Recipients in the UK
ClinicalTrials.gov study NCT04709848. IPD Sharing: NO. Countries: 0. Publications: 0.
Preliminary Evaluation of Two Rapid Diagnostic Test Prototypes for Strongyloides Stercoralis Infection
ClinicalTrials.gov study NCT06368609. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Comparison of transcriptional profiles from 2W1S-specific CD4+ T cells during 2W1S-expressing Salmonella and Strongyloides ratti infections reveals that infectious context drives effector CD4+ T cell
GEO Series GSE134278. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
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International Brain Laboratory public data
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OpenNeuro
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