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77 results for “Synthetic biology”
Fig. 10 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 10. Synthesis of isolaxifolin (369). Reagents and conditions: (a) 3-methyl-2-butenal, Ca(OH), MeOH, 18 ◦ C, 72 h; (b) Ac O, CH Cl, 18 ◦ C, 6 h; (c) 3-methyl-2- 2 2 2 2 buten-1-ol, DEAD, PPh, THF, 0–18 ◦ C, 6 h; (d) Eu(fod), CHCl, 60 ◦ C, 6 h; (e) K CO, MeOH, 0 ◦ C, 1 h.
Fig. 24 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 24. Regioselective synthesis of C-6/C-8 prenylated flavonoids. Reagents and conditions: (a) TEA, TBDMS-Cl, H2SO4, dichloromethane, room temp., 83%; (b) Prenyl alcohol, TPP, DIAD, dichloromethane, ice bath, 56%; (c) Eu(fod), toluene, 140 ◦ C, 81%; (d) NaH, pivaloyl vanilloyl chloride (aq.), tetrahydrofuran, reflux, 3 85%; (e) CuCl, TMS-Cl, dry acetonitrile, RT, 60%; (f) i TBAF (aq.) dry tetrahydrofuran ii Pyrrolidine, H SO, 60%; (g) Pivaloyl chloride, DMAP, dry pyridine, 40 ◦ C, 2 2 4 15 min, H SO dilution; (h) TFA, dichloromethane, water, 30 ◦ C, 72%.
Fig. 7 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 7. Synthesis of icaritin derivatives (237–272). Reagents and conditions: i. bromo-carboxylic acid ethyl esters (2.5–4.0 equiv.), acetone, K2CO3, reflux, 6 h; ii. bromo-carboxylic acid ethyl esters (1.0–1.5 equiv.), acetone, K2CO3, reflux, 6 h; iii. NaOH, MeOH/H2O (2:1), rt, 4 h; iv. glutaric anhydride, DMAP, TEA, DCM, rt, 8 h.
Fig. 4 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 4. Synthesis of antiproliferative prenyl flavonoid derivatives (197–207). Reagents and conditions: (a) CH CN, ZnCl, Et O, HCl g, 0–5 ◦ C; (b) H O, reflux, 2 h; 3 2 2 2 (c) Me SO, K CO, acetone, rt, 0.5 h; (d) benzaldehyde or p-anisaldehyde, KOH, EtOH, H O, rt, 3 h; (e) CH –CHCH Br, K CO, acetone, reflux, 12 h; (f) heat, 2 4 2 3 2 2– 2 2 3 210 ◦ C, 4 h; (g) CH COONa, C H OH, reflux, 24 h; (h) I, pyridine, 90 ◦ C, 16 h; (i) KMnO, HIO, i-PrOH, H O, rt; (j) R R CHP + Ph3Br, n-BuLi, THF, rt, 24 h; (k) 1 3 2 5 2 4 4 2 2 3 equiv BBr3, ClCH2CH2Cl, rt, 2 h; (l) 8 equiv BBr3, ClCH2CH2Cl, reflux, 4 h.
Fig. 6 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 6. Synthesis of potential MDR reversal icariin derivatives (231–236). Reagents and conditions: (a) H2SO4 (2–5 equiv), 90% EtOH, reflux; 1.5 h; (b) 20% H2SO4, MeOH, reflux, 2 h; (c) 20% H SO, MeOH, 25 ◦ C, 4 h; (d) ClSO CH, Et N, 4 h, then HCl; (e) ClSO CH, pyridine, 0 ◦ C, 3 h; then HCl; (f) ClSO NH, DMA, CH Cl, 2 4 2 3 3 2 3 2 2 2 2 0 ◦ C, 3 h; (g) ClSO H, Et N, 0 ◦ C, 3 h; then HCl.
Fig. 5 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 5. Synthesis of 4′-methoxy licoflavanone derivatives (208–230). Reagents and conditions: (a) RX, K CO, dry acetone, room temperature, 1–4 h, 75–86%; (b) 2 3 Propargyl bromide, K2CO3, dry acetone, room temperature, 2 h, 89% (c) TfN3, CuSO4 (aq.), Et3N, CH2Cl2/MeOH, 2–4 h, 90–96% (d) Sodium ascorbate, R–N3, CuSO4⋅5H2O, t-BuOH/water (1:1), 85–93%.
Fig. 27 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 27. Synthesis of C-3-prenylated flavonoids. Reagents and conditions: (a) CH OCH Cl, K CO, acetone 0 ◦ C, RT; (b) 3-methylbut-2-enyl bromide (2 equiv), fresh 3 2 2 3 LDA (2.5 equiv), THF, 75 ◦ C–4 ◦ C, 20 h, 50%; (c) ArCHO (2 equiv), NaHMDS (3 equiv), THF, 75 ◦ C to reflux, 30 h, 13–46%; (d) 4 N HCl, MeOH, reflux, 8–15 h, 22–63%.
Observational Registry of Patients With Rheumatoid Arthritis /Spondyloarthritis Using Biological or Targeted Synthetic DMARDs
ClinicalTrials.gov study NCT04139954. IPD Sharing: YES. Countries: 1. Publications: 1.
PRELOOP Trial: Synthetic Versus Biological Mesh for Prevention of Incisional Hernia After Loop-ileostomy Closure
ClinicalTrials.gov study NCT03445936. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Two-scale dispersal estimation for biological invasions via synthetic likelihood
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Data from: Varying the spatial arrangement of synthetic herbivore-induced plant volatiles and companion plants to improve conservation biological control
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Data from: Biomimicry of iridescent, patterned insect cuticles: comparison of biological and synthetic, cholesteric microcells using hyperspectral imaging
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A quantitative autonomous bioluminescence reporter system with a wide dynamic range for Plant Synthetic Biology
<p>This data set includes: Luminescence (NeoLuc Luminescence), Fluorescence (eGFP) , NeoLuc/eGFP ratios, Area Under The Curve of NeoLuc/eGFP ratios, Normalized Area Under The Curve of Neoluc/eGFP (FBP-RTAs), Firefly Luciferase luminescence (FLuc), Renilla Luciferase luminescence (RLuc), FLuc/RLuc ratios and Normalized FLuc/RLuc values of all experiments in this work. </p>
Fig. 22 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 22. Basic SARs studies of prenylated flavonoids with enzyme inhibitory activity.
Fig. 20 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 20. (continued).
Fig. 20 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 20. Chemical structures of prenylated flavonoids with enzyme inhibitory activity (495–550).
Fig. 13 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 13. Chemical structures of prenylated flavonoids with antimicrobial activity (388–430).
Fig. 17 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 17. (continued).
Fig. 12 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 12. Chemical structures of prenylated flavonoids with anti-Alzheimer activity (370–387).
Fig. 11 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 11. Basic SARs studies of prenylated flavonoids with anti-inflammatory activity.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.