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699 results for “TB”
Determinants of QuantiFERON Plus-diagnosed tuberculosis infection in adult Ugandan TB contacts: A cross-sectional study
<p>Background</p> <p>The tuberculin skin test is commonly used to diagnose latent tuberculosis infection (LTBI) in resource-limited settings, but its specificity is limited by factors including cross-reactivity with BCG vaccine and environmental mycobacteria. Interferon-gamma release assays (IGRA) overcome this problem by detecting <em>M</em>. <em>tuberculosis</em> complex-specific responses, but studies to determine risk factors for IGRA-positivity in high TB burden settings are lacking.</p> <p>Methods</p> <p>We conducted a cross-sectional study to determine factors associated with a positive IGRA by employing the QuantiFERON-TB® Gold-plus (QFT Plus) assay in a cohort of asymptomatic adult TB contacts in Kampala, Uganda. Multivariate logistic regression analysis with forward stepwise logit function was employed to identify independent correlates of QFT Plus-positivity.</p> <p>Results</p> <p>Of the 202 participants enrolled, 129/202 (64%) were female, 173/202 (86%) had a BCG scar, and 67/202 (33%) were HIV-infected. Overall, 105/192 (54%, 95% CI 0.48–0.62) participants had a positive QFT Plus result. Increased risk of QFT-Plus positivity was independently associated with manual employment/unemployment vs. professional employment (adjusted odds ratio (aOR) 2.18, 95% CI 1.01–4.72), a family vs. non-family relation to the index patient (aOR 2.87, 95% CI 1.33–6.18), living in the same vs. a different house as the index (aOR 3.05, 95% CI 1.28–7.29), a higher body mass index (BMI) (aOR per additional kg/m2 1.09, 95% CI 1.00–1.18) and tobacco smoking vs. not (aOR 2.94, 95% CI 1.00–8.60). HIV infection was not associated with QFT-Plus positivity (aOR 0.91, 95% CI 0.42–1.96).</p> <p>Conclusion</p> <p>The prevalence of IGRA positivity in this study population was lower than previously estimated. Tobacco smoking and raised BMI are hitherto unappreciated determinants of LTBI risk in this setting.</p>
TB-CARE: A Novel Convolutional Autoencoder-based Tuberculosis Classification System with Enhanced EfficientNet
<p><span>The novel framework for TB classification using Convolutional AutoencodeR with EfficientNet (TB-CARE) involves the utilization of a convolutional autoencoder for feature extraction, an affinity propagation clustering method for selecting templates, and an enhanced EfficientNet (EEffNet) for classification. Extensive tests are performed on datasets that are freely accessible. The results of our methodology surpassed those of previous approaches, demonstrating its practicality for real-world applications. By leveraging deep learning models within the ensemble method, TB classification achieves a notable area under the receiver operating characteristic of up to 0.99, outperforming other tested classifiers and setting a new benchmark. EEffNet exhibits outstanding performance with an accuracy of 99.8%, sensitivity of 99.8%, and specificity of 99.7% on the NIH chest X-ray dataset and accuracy of 99.6%, sensitivity of 99.9%, and specificity of 99.4% on TBX11 k Dataset. These results indicate that employing features extracted from various image sources can significantly enhance the detection rate.</span></p>
Fluctuation electron microscopy data from amorphous Tb-Co and SiNx
<p>These datasets were used for fluctuation electron microscopy (FEM) analysis of amorphous Tb<sub>17</sub>Co<sub>83</sub>. The Tb<sub>17</sub>Co<sub>83</sub> is 30 nm thick. The deposited Ta is sandwiched between two layers of amorphous 10 nm-thick SiN<sub>x</sub>. Data are also provided for SiN<sub>x</sub> deposited on SiN<sub>x</sub>. Samples include: (1) Tb<sub>17</sub>Co<sub>83 </sub>deposited at 20<sup>o</sup>C, (2) Tb<sub>17</sub>Co<sub>83 </sub>deposited at 200<sup>o</sup>C, (3) Tb<sub>17</sub>Co<sub>83 </sub>deposited at 300<sup>o</sup>C, (4) Tb<sub>17</sub>Co<sub>83 </sub>deposited at 20<sup>o</sup>C and annealed at 200<sup>o</sup>C, and (5) Tb<sub>17</sub>Co<sub>83 </sub>deposited at 20<sup>o</sup>C and annealed at 300<sup>o</sup>C.</p> <p>FEM patterns were collected in a FEI TitanX operated at 200 kV with a convergence angle of 0.51 mrad and a camera length of 300 mm. </p> <p>Samples (1) Tb<sub>17</sub>Co<sub>83 </sub>deposited at 20<sup>o</sup>C and (3) Tb<sub>17</sub>Co<sub>83 </sub>deposited at 300<sup>o</sup>C were tilted between 0<sup>o</sup> and 40<sup>o</sup> in 5<sup>o</sup> increments. The tilted FEM data is also included.</p> <p><strong>File types</strong></p> <p>.dm4 (Gatan DigitalMicrograph) files are provided with the raw scanning nanodiffraction data for each sample. Each sample has multiple associated .dm4 files because measurements were repeated for statistical purposes.</p> <p><strong>Data processing</strong></p> <p>For the steps involved in FEM data processing, please visit: https://github.com/ScottLabUCB/FEM</p> <p><strong>File name format</strong></p> <p>Using "gRTa200_t00_200kV_cl300_ca0p51_exp0p3_spot9_ss5nm_04.dm4" as an example, the naming format is:</p> <p>"sample descriptor _ tilt angle _ TEM voltage_camera length [mm] _ convergence angle [mrad] _exposure [sec] _spot size _ step size between probe positions [nm]_ data set number.dm4"</p> <p>Data are from Tb<sub>17</sub>Co<sub>83 </sub>capped with SiN<sub>x</sub> unless only "SiN" is stated in the descriptor, in which case the data are from SiN<sub>x</sub>.</p> <p>For the tilted data, the naming format is:</p> <p>"sample descriptor _ tilt angle _ spot size _ exposure [sec] convergence angle [mrad]_ bin factor _camera length _ TEM voltage _ data set number.dm4"</p> <p>For all data, the step size is 5 nm, the spot size is 9, the exposure is 0.3 seconds, the convergence angle is 0.51 mrad, the camera length in 300 mm, and the TEM extraction voltage is 200 kV.</p> <p> </p>
A Study to Evaluate the Safety of AERAS-402 in Adults Recently Treated for Pulmonary TB
ClinicalTrials.gov study NCT02414828. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Shorter and Safer Treatment Regimens for Latent TB
ClinicalTrials.gov study NCT06498414. IPD Sharing: YES. Countries: 5. Publications: 2.
A Trial to Evaluate OPC 67683 in Participants With Pulmonary Sputum Culture-positive, Multidrug-resistant Tuberculosis (TB)
ClinicalTrials.gov study NCT00685360. IPD Sharing: YES. Countries: 9. Publications: 1.
Treatment Shortening of MDR-TB Using Existing and New Drugs
ClinicalTrials.gov study NCT02619994. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Simplified Isoniazid Preventive Therapy Strategy to Reduce TB Burden
ClinicalTrials.gov study NCT03315962. IPD Sharing: NO. Countries: 1. Publications: 3.
Safety and Immunogenicity of a Candidate Tuberculosis (TB) Vaccine in Adults With TB Disease
ClinicalTrials.gov study NCT01424501. IPD Sharing: YES. Countries: 2. Publications: 2.
A Clinical Risk Score for Early Management of TB in Uganda
ClinicalTrials.gov study NCT05122624. IPD Sharing: NO. Countries: 1. Publications: 1.
TMC207-TiDP13-C208: Anti-bacterial Activity, Safety, and Tolerability of TMC207 in Participants With Multi-drug Resistant Mycobacterium Tuberculosis (MDR-TB).
ClinicalTrials.gov study NCT00449644. IPD Sharing: Not stated. Countries: 8. Publications: 5.
High-Dose Isoniazid Among Adult Patients With Different Genetic Variants of INH-Resistant Tuberculosis (TB)
ClinicalTrials.gov study NCT01936831. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Safety, Tolerance and Pharmacokinetics of Raltegravir-Containing Antiretroviral Therapy in Infants, Children Infected With HIV and TB
ClinicalTrials.gov study NCT01751568. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Trial of High-Dose Rifampin in Patients With TB
ClinicalTrials.gov study NCT01408914. IPD Sharing: Not stated. Countries: 3. Publications: 3.
Evaluation of Safety, Immunogenicity, and Prevention of TB With AERAS-404 and BCG Revaccination in Healthy Adolescents
ClinicalTrials.gov study NCT02075203. IPD Sharing: NO. Countries: 1. Publications: 2.
Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV)
ClinicalTrials.gov study NCT04930744. IPD Sharing: YES. Countries: 1. Publications: 36.
REMEMBER: Reducing Early Mortality & Morbidity by Empiric Tuberculosis (TB) Treatment
ClinicalTrials.gov study NCT01380080. IPD Sharing: Not stated. Countries: 10. Publications: 2.
Brief Rifapentine-Isoniazid Evaluation for TB Prevention (BRIEF TB)
ClinicalTrials.gov study NCT01404312. IPD Sharing: Not stated. Countries: 10. Publications: 7.
Efficacy and Safety of Levofloxacin for the Treatment of MDR-TB
ClinicalTrials.gov study NCT01918397. IPD Sharing: NO. Countries: 2. Publications: 5.
Evaluation of 8 Weeks of Treatment With the Combination of Moxifloxacin, PA-824 and Pyrazinamide in Patients With Drug Sensitive and Multi Drug-Resistant Pulmonary Tuberculosis (TB) (NC-002)
ClinicalTrials.gov study NCT01498419. IPD Sharing: Not stated. Countries: 2. Publications: 1.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.