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85 results for “Translation models”
Are researchers moving away from animal models as a result of poor clinical translation in the field of stroke? an analysis of opinion papers
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Data from: A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?
Background: The development of therapeutics is often characterized by promising animal research that fails to translate into clinical efficacy; this holds for the development of gene therapy in glioma. We tested the hypothesis that this is because of limitations in the internal and external validity of studies reporting the use of gene therapy in experimental glioma. Method: We systematically identified studies testing gene therapy in rodent glioma models by searching three online databases. The number of animals treated and median survival were extracted and studies graded using a quality checklist. We calculated median survival ratios and used random effects meta-analysis to estimate efficacy. We explored effects of study design and quality and searched for evidence of publication bias. Results: We identified 193 publications using gene therapy in experimental glioma, including 6,366 animals. Overall, gene therapy improved median survival by a factor of 1.60 (95% CI 1.53–1.67). Study quality was low and the type of gene therapy did not account for differences in outcome. Study design characteristics accounted for a significant proportion of between-study heterogeneity. We observed similar findings in a data subset limited to the most common gene therapy. Conclusion: As the dysregulation of key molecular pathways is characteristic of gliomas, gene therapy remains a promising treatment for glioma. Nevertheless, we have identified areas for improvement in conduct and reporting of studies, and we provide a basis for sample size calculations. Further work should focus on genes of interest in paradigms recapitulating human disease. This might improve the translation of such therapies into the clinic.
Post-Translational Modification Prediction via Prompt-Based Fine-Tuning of a GPT-2 Model
<p>Training and Benchmark datasets for 19 PTMGPT2 models</p>
His-MMDM: Multi-domain and Multi-omics Translation of Histopathology Images with Diffusion Models
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His-MMDM: Multi-domain and Multi-omics Translation of Histopathology Images with Diffusion Models
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His-MMDM: Multi-domain and Multi-omics Translation of Histopathology Images with Diffusion Models
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His-MMDM: Multi-domain and Multi-omics Translation of Histopathology Images with Diffusion Models
<p>part aa of HMU1st</p>
Characterization of Neutrophil Functional Responses to SARS-CoV-2 Infection in a Translational Feline Model for COVID-19
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Dataset related to "Translational approach to assess brain injury after cardiac arrest in preclinical models: a narrative review"
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Translational Model of Anhedonia
ClinicalTrials.gov study NCT03856177. IPD Sharing: NO. Countries: 1. Publications: 0.
Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model
ClinicalTrials.gov study NCT07094061. IPD Sharing: YES. Countries: 1. Publications: 0.
Clinical Translation Research on a Multi-omics Breast Cancer Distant Metastasis Prediction Model Empowered by Artificial Intelligence
ClinicalTrials.gov study NCT07252986. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?
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Systematic disruption of zebrafish fibrillin genes identifies a translational zebrafish model for Marfan syndrome
GEO Series GSE300393. Danio rerio. 16 samples. Type: Expression profiling by high throughput sequencing.
Translation value of the bleomycin rat model for the treatment of patients with Idiopathic Pulmonary Fibrosis (IPF)
GEO Series GSE48455. Rattus norvegicus. 72 samples. Type: Expression profiling by array.
Cynomolgus macaques as a translational model of human immune responses to yellow fever 17D vaccination
GEO Series GSE253538. Macaca fascicularis. 81 samples. Type: Expression profiling by high throughput sequencing.
The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research
GEO Series GSE188158. Mus musculus. 47 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Gene-environment interaction elicits dystonia-like features and impaired translational regulation in a DYT-TOR1A mouse model (RNA-Seq)
GEO Series GSE249875. Mus musculus. 72 samples. Type: Expression profiling by high throughput sequencing.
Translational profiling reveals novel gene expression changes in the direct and indirect pathways in a mouse model of Levodopa induced dyskinesia
GEO Series GSE291024. Mus musculus. 23 samples. Type: Expression profiling by array.
Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model
GEO Series GSE109345. Mus musculus. 78 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.