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467 results for “Trial Data”
Data presented in Multi-trial analysis of HIV-1 envelope gp41-reactive antibodies among global recipients of candidate HIV-1 vaccines.
<p>This folder contains datasets analyzed in the manuscript:</p> <p>Multi-trial analysis of HIV-1 envelope gp41-reactive antibodies among global recipients of candidate HIV-1 vaccines.</p> <p>Frontiers in Immunology<br> Sec. Vaccines and Molecular Therapeutics<br> doi: 10.3389/fimmu.2022.983313</p>
Animal and pasture data of AGROMIX WP3 pilot site trial at Tenuta di Paganico (GR) Italy (Spring 2021)
<p>Dataset of collected data on herbage, production , animal intake, and animal welfare in spring 2021 at Tenuta di Paganico (GR) Italy</p>
Supplementary material 1 from: Motloung R, Robertson M, Rouget M, Wilson J (2014) Forestry trial data can be used to evaluate climate-based species distribution models in predicting tree invasions. NeoBiota 20: 31-48. https://doi.org/10.3897/neobiota.20.5778
Current and potential distributions of sixteen species that are not widespread in southern Africa arranged on the basis of their suitable range size : a) Acacia paradoxa, b) A. cultriformis, c) A. falciformis, d) A. pendula, e) A. rubida, f) A. stricta, g) A. retinodes, h) A. fimbriata, i) A. aneura, j) A. viscidula, k) A. acuminata, l) A. adunca, m) A. binervata, n) A. schinoides, o) A. prominens, p) A. mangium. The grey shading indicates areas that SDMs have identified as suitable by SDMs while the white ones are unsuitable.
STEMForYouth: Trials and Outreach Data
<p>Data collected during the trials implementation of the STEM4youth project from September 2017 to May 2018. </p> <p>Students developed the following STEM4youth sub-courses: Physics, Chemistry, Mathematics, Engineering, Astronomy and Medicine in six European countries: Poland, Greece, Czech Republic, Slovenia, Italy and Spain.</p> <p>Students freely accepted to fill questionnaires before and after carrying out the activities, being conscious that they were part of a research study. The data was collected in paper-based format or computer-based format. In the last case, questionnaires were generated on Google Forms. In addition, a control group was designated in Greece, Czech Republic, Slovenia and Spain to ensure the validity of the results.</p> <p>All participants in the trials signed an informed consent to participate, in agreement with the Spanish Law for Personal Data Protection or similar laws in participant countries. This procedure was approved by the Ethics Committee in each country, and all methods were performed in accordance with the relevant guidelines and regulations.</p> <p>The questionnaire employed for gathering this data is an amended version of Diego-Mantecón’s (2012) student mathematics-related beliefs instrument. If you like to use this questionnaire and get further information about how to use it, please contact the original author at this email: diegojm@unican.es</p>
Data supplement to: "Refractory depression - Mechanisms & Efficacy of Radically Open Dialectical Behaviour Therapy (RefraMED): findings of randomised trial on benefits and harms"
<p>Data and code to support primary analyses reported in "Refractory depression – mechanisms and efficacy of radically open dialectical behaviour therapy (RefraMED): findings of a randomised trial on benefits and harms". British Journal of Psychiatry. doi: 10.1192/bjp.2019.53</p>
Continuous Digital Monitoring of Walking Speed in Frail Elderly Patients: Noninterventional Validation Study and Longitudinal Clinical Trial (Data for independent validation study)
<p>Digital technologies and advanced analytics have drastically improved our ability to capture and interpret health relevant data from patients. However, to date, limited data and results have been published detailing real-world patient compliance, demonstrating accuracy in target indications or examining what novel insights and clinical value can be derived. Here we present novel, digital mobility data from two studies: an independent, non-interventional validation study with elderly, naturally slow walking subjects, and a global, multi-site phase IIb clinical trial involving patients with age-related muscle loss and slow walking speed (sarcopenia). Based on these data, we validate the accuracy of a novel algorithm for capturing in-clinic and real-world gait speed in frail, slow-walking adults. We demonstrate the feasibility of continuous monitoring with a wearable inertial sensor in elderly adults in real-world settings, and propose minimum thresholds for compliance required for robust capture of gait behaviors in this population. We also show how simple, inferred contextual information, describing the length of a given walking bout, can explain some of the variation in real-world gait speed, and use this information to demonstrate for the first time a relationship between in-clinic performance and real-world gait speed behavior. This work lays a foundation for exploration of the clinical relevance and value of such measures and is a first step in building a more complete chain of evidence between standardized physical performance assessment, real-world behavior, and subjective perceptions of mobility, independence and health.</p> <p>This dataset contains data collected during the independent validation study: derived data from raw accelerometry data, and summary performance data.</p> <p>The full dataset, including raw accelerometry data, is available here: <a href="https://mueller-et-al-2019.s3.amazonaws.com/index.html">https://mueller-et-al-2019.s3.amazonaws.com/index.html</a></p>
Data of 14 participants in the RCT titled Acute effects of virtual reality exercise bike games on psychophysiological outcomes in college North-African adolescents with cerebral palsy: A randomized clinical trial
<p>It is an Excel file including the numerical data of the 14 participants included in the study titled: <a name="_Hlk151119211"></a><span>Acute effects of virtual reality exercise bike games on psychophysiological outcomes in college North-African adolescents with cerebral palsy: A randomized clinical trial</span></p>
Animal and microclimate data of AGROMIX WP3 pilot site trial at Tenuta di Paganico (GR) Italy - (2021 and 2022)
<p>Datasets of collected data on (i) animal weight and average daily gain, (ii) hair cortisol, (iii) blood glucose (iv) and black globe humidity index during the trial conducted in Spring and summer 2021 and 2022 at the AGROMIX trial site of Tenuta di Paganico (GR), Italy.</p>
Agronomic performance of cultivar mixtures of winter wheat varieties, obtained from mixture field trials at 5 locations in Switzerland from 2019 to 2020, together with yield data from the varieties in pure stand obtained from the national variety testing trial network
<p>This dataset contains agronomic parameters of 32 winter wheat variety mixtures tested during 2 growing seasons (2019-2020) at 5 locations in Switzerland, as well as yield data of these varieties in pure stands originating from the Swiss national variety testing network. The dataset has been used to investigate the links between asynchrony and yield stability, published in <a href="https://doi.org/10.1002/csc2.21151">https://doi.org/10.1002/csc2.21151</a>. </p> <p>The field trials were performed under the Swiss Extenso (low input) conditions, conducted by Agroscope and DSP. </p> <h2>Methods </h2> <p><em>Field trials </em></p> <p>The experiment took place in five sites across Switzerland, in 2019 and 2020. The sites were located in Nyon (1260), Delley (1567), Utzenstorf (3428), Zurich (8046), and Ellighausen (8566).</p> <p>Experimental communities consisted of 32 different two-variety mixtures grown in 7.1-m<sup>2</sup> plots (1.5 × 4.7 m). We replicated the mixture experiment three times per site with the exact same variety composition. We used a randomized block design, with plots being randomized at each site within each block. Density of sowing was 350 seeds/m<sup>2</sup>, and seeds were mixed beforehand at a 50:50 ratio in terms of mass. We used the 50:50 mass ratio as this is what is generally done in practice by farmers and seed suppliers. Plots were sown mechanically each autumn. The plots were mechanically fertilized according to the Principles of Agricultural Crop Fertilisation in Switzerland (Federal Office for Agriculture) with an average of 140 kg N/ha (ammonium nitrate), applied in three splits (40 at the tillering stage—60 at stem elongation stage—40 when the flag leaf is visible). The experimental trials were conducted following the extenso Swiss scheme, which means that there was no application of any fungicide, insecticide, or plant growth regulator. </p> <p>The performances of single varieties were obtained by going through the trials of the national variety testing program. We gathered the data for the years 2018/2019 and 2019/2020. The data regarding single varieties could be obtained for three out of the five sites used for the mixtures: 1260, 1567, and 8566. Because there were no national variety trials at the two other sites (8046, 3428), we could not get any data for single varieties in these sites. Thus, all further analyses including single variety data were only done for the three sites mentioned above. At each of these sites, the variety trials were located on the same plot as the mixture trials, even though a little further apart. Therefore, soil parameters and crop precedents were the same between the mixture and variety testing trials. Furthermore, we only selected the national variety testing trials that respected the <em>extenso</em> conditions, that is, no fungicide, pesticide, or growth regulator application, and that received the same amount of fertilization as the mixture trials. In 8566 and 1567, sowing and harvesting dates were identical between the two trials; in 1260, sowing and harvesting dates could vary but remained within a week of each other.</p> <p> </p> <p><em>Data collection </em></p> <p>For each plot, heading dates were monitored, and average height at BBCH 59–75 was measured.</p> <p>The prevalence of diseases was scored twice in the growing season. Specifically, the severity of brown rust, yellow rust, powdery mildew, and Septoria tritici blotch was assessed. This was performed by grading each individual plot from 1 to 9 for each disease, with 1 representing no disease and 9 a complete infection. The scoring scale follows a logistic progression based on the symptoms of the top three leaves. We used the data from the final scoring for statistical analysis, as the disease severity was usually more important then.</p> <p>At maturity, we harvested each plot with a combine harvester. The harvested grains were dried when needed, weighed a first time, then sorted and cleaned by air and with a sieve cleaner, and subsequently weighted again. We measured specific weight and water content at the plot level using a Dickey-John machine (GAC 2100). Grain yield was subsequently standardized to 15% of humidity. Protein content was measured at the site level with a near-infrared instrument (ProxiMate; Büchi instruments).</p>
Data and Code Supplement to: "Processes of change in a randomized clinical trial of Radically Open Dialectical Behavior Therapy (RO DBT) for adults with treatment refractory depression"
<p>Dataset to support secondary analyses reported in "Processes of change in a randomized clinical trial of Radically Open Dialectical Behavior Therapy (RO DBT) for adults with treatment refractory depression" in the Journal of Consulting and Clinical Psychology</p>
Data_Synthesis_Musa_Trials_BLSD: v1.0.0
<p>Companion code and data for the paper "Rank-based data synthesis of heterogeneous trials to identify the effects of climatic factors on the reaction of <em>Musa</em> genotypes to black leaf streak disease".</p>
Loss of socioemotional and occupational roles in people with Long COVID according to sociodemographic and clinical factors: Secondary data from Randomized Clinical Trial.
<p>This is a cross-sectional study was carried out with the participation of 100 patients diagnosed with Long-COVID, over 18 years of age and attended by Primary Health Care in the Autonomous Community of Aragon. The purpose of this study is to analyse the loss of socioemotional and occupational roles that people with Long COVID have suffered in their lives as a consequence of the disease. As a secondary objective, it was proposed to analyze the sociodemographic and clinical factors associated with this loss of roles. The main study variable was the loss of significant socioemotional and occupational roles of the participants. Sociodemographic and clinical data were also collected through a structured interview.</p>
Context-dependent multimodal behaviour in a coral reef fish: Stage 1 & 2 total duration and count data in behaviour trials
Open the record for dataset details and reuse information.
CALERIE trial molecular data summary: DNA methylation, mRNA, smRNA for blood, adipose, and muscle
Open the record for dataset details and reuse information.
Data from: A village doctor-led mobile health intervention for cardiovascular risk reduction in rural China: cluster randomised controlled trial
Open the record for dataset details and reuse information.
Microclimatic data trials for various fabrics
Data from lab trials examining various microclimatic parameters such as humidity, light intensity, and temperature under various fabrics such as nursery, canvas, and burlap. Data was collected using pendant loggers.
Raw data related to: Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)
<p><strong>Abstract</strong></p> <p>Fatty liver disease is a serious complication of childhood obesity. Calorie-restricted regimen (RCR) is one of the e ective therapy for this condition. Aim of the study was to evaluate the effect of lycopene-rich tomato sauce with oregano and basil extracts in obese children with fatty liver on RCR. 61 obese children with fatty liver were enrolled, 52 completed the study. A randomized cross over clinical trial was performed. Participants were assigned to RCR alone or with a supplement of lycopene-rich tomato juice for 60 days; subsequently, the groups were switched to the alternative regimen for the next 60 days. Reduction in BMI, HOMA-IR, cholesterol, triglycerides, liver size, and steatosis was more profound in tomato-supplemented group. Leptin decreased in both groups whereas adiponectin raised only after tomato supplementation. RCR is associated with the impaired engagement of T-cells glycolysis and proliferation, tomato-supplementation resulted in glycolytic metabolic activation of T-cells. Tomato juice ameliorates glucose and lipid metabolism in obese children, improve oxidative and inflammatory state and modulates the mitochondrial metabolism of T-cells contributing to a maintenance of a proper immune surveillance in children, impaired by RCR. The addition of tomato to RCR could be considered a protective and preventive support to obese child.</p> <p><strong>Progetto giovani ricercatori </strong>[GR-2016-02363725] dal titolo: "Immune Tolerance, Metabolism and Multiple Sclerosis: Novel Molecular Tools to Monitor Disease Pathogenesis and Progression"</p>
Data set of trials perfomed in Pont Saint Martin Data Center, pilot of CATALYST Project
<blockquote> <p>The zip file contains data sets being the input and/or output of the test case exploited in Pont Saint Martin Data Center, as pilot of CATALYST Project (H2020-EE-2016-2017)</p> </blockquote>
Data from: Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: two open-label, randomized, safety trials
Background: Primaquine (PQ) actively clears mature Plasmodium falciparum gametocytes but in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals can cause hemolysis. We assessed the safety of low-dose PQ in combination with artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (DP) in G6PDd African males with asymptomatic P. falciparum malaria. Methods and findings: In Burkina Faso, G6PDd adult males were randomized to treatment with AL alone (n = 10) or with PQ at 0.25 (n = 20) or 0.40 mg/kg (n = 20) dosage; G6PD-normal males received AL plus 0.25 (n = 10) or 0.40 mg/kg (n = 10) PQ. In The Gambia, G6PDd adult males and boys received DP alone (n = 10) or with 0.25 mg/kg PQ (n = 20); G6PD-normal males received DP plus 0.25 (n = 10) or 0.40 mg/kg (n = 10) PQ. The primary study endpoint was change in hemoglobin concentration during the 28-day follow-up. Cytochrome P-450 isoenzyme 2D6 (CYP2D6) metabolizer status, gametocyte carriage, haptoglobin, lactate dehydrogenase levels and reticulocyte counts were also determined. In Burkina Faso, the mean maximum absolute change in hemoglobin was -2.13 g/dL (95% confidence interval [CI], -2.78, -1.49) in G6PDd individuals randomized to 0.25 PQ mg/kg and -2.29 g/dL (95% CI, -2.79, -1.79) in those receiving 0.40 PQ mg/kg. In The Gambia, the mean maximum absolute change in hemoglobin concentration was -1.83 g/dL (95% CI, -2.19, -1.47) in G6PDd individuals receiving 0.25 PQ mg/kg. After adjustment for baseline concentrations, hemoglobin reductions in G6PDd individuals in Burkina Faso were more pronounced compared to those in G6PD-normal individuals receiving the same PQ doses (P = 0.062 and P = 0.022, respectively). Hemoglobin levels normalized during follow-up. Abnormal haptoglobin and lactate dehydrogenase levels provided additional evidence of mild transient hemolysis post-PQ. Conclusions: Single low-dose PQ in combination with AL and DP was associated with mild and transient reductions in hemoglobin. None of the study participants developed moderate or severe anemia; there were no severe adverse events. This indicates that single low-dose PQ is safe in G6PDd African males when used with artemisinin-based combination therapy.
Data from: Landscape genomics and a common garden trial reveal adaptive differentiation to temperature across Europe in the tree species Alnus glutinosa
The adaptive potential of tree species to cope with climate change has important ecological and economic implications. Many temperate tree species experience a wide range of environmental conditions, suggesting high adaptability to new environmental conditions. We investigated adaptation to regional climate in the drought-sensitive tree species Alnus glutinosa (Black alder), using a complementary approach that integrates genomic, phenotypic and landscape data. A total of 24 European populations were studied in a common garden and through landscape genomic approaches. Genotyping-By-Sequencing was used to identify SNPs across the genome, resulting in 1990 SNPs. Although a relatively low percentage of putative adaptive SNPs was detected (2.86% outlier SNPs), we observed clear associations among outlier allele frequencies, temperature, and plant traits. In line with the typical drought avoiding nature of A. glutinosa, leaf size varied according to a temperature gradient and significant associations with multiple outlier loci were observed, corroborating the ecological relevance of the observed outlier SNPs. Moreover, the lack of isolation-by-distance, the very low genetic differentiation among populations and the high intra-population genetic variation all support the notion that high gene exchange combined with strong environmental selection promotes adaptation to environmental cues.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.