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22
datasets available to search
ShareScore release 0.9.0
Dataset results
22 results for “UGT1A1”
UGT1A1 Genotyping in Taiwanese Cancer Patients
ClinicalTrials.gov study NCT05792943. IPD Sharing: NO. Countries: 0. Publications: 0.
Dataset related to article "Implementing Pre-Therapeutic UGT1A1 Genotyping in Clinical Practice: A Real-Life Study"
<p>This record contains raw data related to article “Implementing Pre-Therapeutic<em> UGT1A1</em> Genotyping in Clinical Practice: A Real-Life Study"</p> <p>Current guidelines recommend pre-therapeutic <em>UGT1A1</em> genotyping to guide irinotecan dosing, but the usefulness of this approach remains to be clarified. In 247 patients with advanced gastrointestinal cancers undergoing irinotecan-based chemotherapy, we prospectively performed <em>UGT1A1*28</em> genotyping and we analyzed the incidence of severe neutropenia according to genotype-guided dose reductions. Overall, 28 (11.3%) and 92 (37.2%) patients were homozygous or heterozygous <em>UGT1A1*28</em> carriers, respectively. Grade ≥ 3 neutropenia was reported in 39% of homozygous patients receiving an upfront dose reduction of irinotecan (median 40%, range 22-58%), in 20% of heterozygous or wild-type patients receiving full dose (OR<sub>vs*28/*28 genotype</sub> = 0.38; 95% CI: 0.14-1.03; <em>p</em> = 0.058), and in 15.3% of those receiving a reduced dose for clinical reasons (OR <sub>vs*28/*28 genotype</sub> = 0.28, 95% IC: 0.12-0.67; <em>p</em> = 0.004). Occurrence of severe neutropenia was inversely associated with dose reduction in <em>UGT1A1*28</em> homozygous carriers (OR<sub>x10 unit</sub> = 0.62, 95% CI: 0.27-1.40, <em>p</em> = 0.249) and <em>UGT1A1</em> heterozygous or wild-type patients (OR<sub>x10 unit</sub> = 0.87, 95% CI: 0.59-1.28, <em>p</em> = 0.478). Incidence of severe neutropenia was related to irinotecan doses and <em>UGT1A1</em> polymorphisms. Upfront irinotecan dose reductions do not reduce the burden of grade ≥ 3 neutropenia in <em>UGT1A1*28</em> homozygous carriers.</p>
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