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69 results for “active transport”
Data for: Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity
<p>Inflammation causes pain by shifting the balance of ionic currents in nociceptors towards depolarization, leading to hyperexcitability. The ensemble of ion channels within the plasma membrane is regulated by processes including biogenesis, transport, and degradation. Thus, alterations in ion channel trafficking may influence excitability. Sodium channel Na<sub>V</sub>1.7 and potassium channel K<sub>V</sub>7.2 promote and oppose excitability in nociceptors, respectively. We used live-cell imaging to investigate mechanisms by which inflammatory mediators modulate the abundance of these channels at axonal surfaces through transcription, vesicular loading, axonal transport, exocytosis, and endocytosis. Inflammatory mediators induced a Na<sub>V</sub>1.7-dependent increase in activity in distal axons. Further, inflammation increased the abundance of Na<sub>V</sub>1.7, but not of K<sub>V</sub>7.2, at axonal surfaces by selectively increasing channel loading into anterograde transport vesicles and insertion at the membrane, without affecting retrograde transport. These results uncover a cell-biological mechanism for inflammatory pain and suggest Na<sub>V</sub>1.7 trafficking as a potential therapeutic target.</p>
Fig. 4. 109 in ABCG transporter proteins with beneficial activity on plants
Fig. 4. 109Cd radioactivity in shoots and roots of Arabidopsis plants measured using liquid scintillation counter (Kim et al., 2007).
Fig. 1 in ABCG transporter proteins with beneficial activity on plants
Fig. 1. Kanamycin resistance in T1 transgenic seeds with pABC. (a) Segregation of T1 seeds when plated on 200 mg/l of kanamycin containing medium. (b) Northern blot analysis shows expression of AtABCG19 gene (Mentewab and Stewart 2005).
Fig. 3 in ABCG transporter proteins with beneficial activity on plants
Fig. 3. Arabidopsis plants grown in medium containing different concentrations of Cd and Pb. (a) Decrease in growth of plants with AtPDR8-RNAi (8i-2) and AtPDR8 knockout plants(ko-1), whereas normal growth occurs in wild-type plants(WT) in media containing different concentrations of CdCl2. (b) Decreased resistance to Pb in Arabidopsis plants with 8i-2 and knockout of AtPDR8 (ko-2) when grown in Pb(NO3)2 containing medium (Kim et al., 2007).
Fig. 6 in ABCG transporter proteins with beneficial activity on plants
Fig. 6. Mutants of AtABCG26 with loss of function (abcg26-1) show less amount of self-pollination due to impaired sporopollenin formation whereas wild type plants with normal AtABCG26 perform usual self-pollination (Choi et al., 2011).
Fig. 2 in ABCG transporter proteins with beneficial activity on plants
Fig. 2. Transport of Abscisic acid (ABA) during water stress in plant mediated by AtABCG25 and AtABCG40 (Kang et al., 2011).
Fig. 5 in ABCG transporter proteins with beneficial activity on plants
Fig. 5. ABCG transporters that play important role in cuticle development by transporting cuticular wax/cutin (Kang et al., 2011).
Quantification of Dopamine Active Transporter (DAT) in Humans: Validation of a New Radiophamaceutical, the [18F] LBT-999
ClinicalTrials.gov study NCT02393027. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Increased Activity of a Renal Salt Transporter (ENaC) in Diabetic Kidney Disease
ClinicalTrials.gov study NCT01918488. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Going Places: A Multi-level Intervention to Improve Youth Transportation Efficacy and Physical Activity
ClinicalTrials.gov study NCT07044375. IPD Sharing: NO. Countries: 1. Publications: 4.
Icodextrin Effects on Glucose Transporter Activation and Mediators of Fibrosis
ClinicalTrials.gov study NCT02133313. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Effects of Sodium-glucose Co-transporter-2( SGLT-2 ) Inhibition on Sympathetic Nervous System Activity in Humans
ClinicalTrials.gov study NCT03912909. IPD Sharing: NO. Countries: 1. Publications: 9.
Chronic Obstructive Pulmonary Disease (COPD) Activity: Serotonin Transporter (SERT), Cytokines and Depression (CASCADE Study)
ClinicalTrials.gov study NCT01074515. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data for: Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity
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Data From: Active sinking particles: Flow and transport dynamics due to sessile suspension feeders on sinking aggregates
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Data file for the paper: Colleen Jackson, Leonard Raymakers, Martijn Mulder and Anthony RJ Kucernak, "Assessing Electrocatalyst Hydrogen Activity and CO Tolerance: Comparison of Performance obtained using the High Mass Transport 'Floating Electrode' Technique and in Electrochemical Hydrogen Pumps", Applied Catalysis B: Environmental, 2020, https://doi.org/10.1016/j.apcatb.2020.118734
<p>This Excel spreadsheet contains the data used in generation of the figures in the paper</p> <p>Article title: Assessing Electrocatalyst Hydrogen Activity and CO Tolerance: Comparison of Performance obtained using the High Mass Transport 'Floating Electrode' Technique and in Electrochemical Hydrogen Pumps</p> <p>Journal title: Applied Catalysis B: Environmental, 2020</p> <p>Corresponding author: Professor ARJ Kucernak</p> <p>First author: Dr. C. Jackson</p> <p>First published version available online: 7-FEB-2020</p> <p>DOI information: 10.1016/j.apcatb.2020.118734</p> <p> </p>
Methoxylated aromatic compounds modulate the transport activity of Methermicoccus shengliensis MATE family transporter
<p>RNAseq raw data</p>
Enhance physical activity by designing school based active transport interventions. A systematic review with meta-analysis.
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Effects of Antidepressant Therapy on Brain Dopamine Transporter Activity in People With Major Depression
ClinicalTrials.gov study NCT00655057. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Active Transport Educational Program Based on the Ecological Model on Improving the Physical and Mental Health: MOV-ES Project
ClinicalTrials.gov study NCT06357065. IPD Sharing: NO. Countries: 0. Publications: 53.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.