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287 results for “adenosine”
Atomistic simulations of the adenosine A2 receptor in membranes with varying levels of SDPE
<p>An adenosine A2 receptor was simulated in membranes consisting of DSPC, cholesterol (20 mol%), and varying levels (0, 4, or 8 mol%) of SDPE with a polyunsaturated chain. Upon increasing SDPE concentration, the concentration of DSPC was correspondingly decreased. The initial structures for these simulations were obtained from the final structures of corresponding coarse-grained simulations, where an SDPE-rich corona formed around the receptor. After fine-graining, the systems were simulated using the CHARMM36 [1] force field for 200 ns using the GROMACS package [2].</p> <p>These simulations were also repeated in the absence of protein. These systems were set up using the CHARMM-GUI web portal [3]. The corresponding files have the 'NOPROT' suffix, and the simulation parameter file is called md_noprot.mdp.</p> <p>For details on the fine-graining and the simulation protocol, please see the related paper at DOI: 10.1371/journal.pcbi.1007033.</p> <p>The files named PUFA_X.* correspond to simulations with X mol% of SDPE with the protein, whereas the files names PUFA_X_NOPROT.* are the corresponding files in the absence of the protein. For each concentration, a run input file (tpr) and the simulation outputs (xtc, edr, log, gro) are provided. Moreover, the simulations can be extended using the provided cpt files.</p> <p>Moreover, the files required to generate the run input file are also provided. For each system, a topology file (top) and an index file (ndx) are provided. The CHARMM36 force field and the molecule definitions (itp) referenced by the topology are also provided. The used simulation parameters are provided in the md.mdp file. For the fine-graining of SDPE, the mapping file is also provided (sdpe.charmm36.map).</p> <p>[1] <strong>DOI: </strong>10.1021/jp101759q</p> <p>[2] <strong>DOI: </strong>10.1016/j.softx.2015.06.001</p> <p>[3] <strong>DOI: </strong>10.1021/acs.jctc.5b00935</p>
Allosteric modulation of the adenosine A2A receptor by cholesterol
<p>Cholesterol is a major component of the cell membrane and commonly regulates membrane protein function. Here, we investigate how cholesterol modulates the conformational equilibria and signaling of the adenosine A2A receptor (A2AR) in reconstituted phospholipid nanodiscs. This model system conveniently excludes possible effects arising from cholesterol-induced phase separation or receptor oligomerization and focuses on the question of allostery. GTP hydrolysis assays show that cholesterol weakly enhances the basal signaling of A2AR while decreasing the agonist EC50. Fluorine nuclear magnetic resonance (19F NMR) spectroscopy shows that this enhancement arises from an increase in the receptor's active state population and a G-protein-bound precoupled state. 19F NMR of fluorinated cholesterol analogs reveals transient interactions with A2AR, indicating a lack of high-affinity binding or direct allosteric modulation. The combined results suggest that the observed allosteric effects are largely indirect and originate from cholesterol-mediated changes in membrane properties, as shown by membrane fluidity measurements and high-pressure NMR.</p>
Adenosine Cardioplegia; Improved Cardioprotection?
ClinicalTrials.gov study NCT01123525. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Adenosine vs AF Termination for Paroxysmal AF Ablation
ClinicalTrials.gov study NCT02238392. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Myocardial Protection With Adenosine During Primary Percutaneous Coronary Intervention in Pts With STEMI
ClinicalTrials.gov study NCT00781404. IPD Sharing: Not stated. Countries: 1. Publications: 1.
THE REOPEN-AMI STUDY - Intracoronary Nitroprusside Versus Adenosine in Acute Myocardial Infarction
ClinicalTrials.gov study NCT00590070. IPD Sharing: Not stated. Countries: 1. Publications: 25.
Study to Evaluate Adenosine 2A Receptor Agonist (Regadenoson) in Patients Undergoing Lung Transplantation
ClinicalTrials.gov study NCT03072589. IPD Sharing: NO. Countries: 1. Publications: 1.
Salvage: Postconditioning With Adenosine for STEMI
ClinicalTrials.gov study NCT00284323. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dobutamine vs Adenosine CMR Study
ClinicalTrials.gov study NCT03661827. IPD Sharing: NO. Countries: 1. Publications: 11.
Ticagrelor and Adenosine
ClinicalTrials.gov study NCT01996735. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Strimvelis Registry Study to Follow-up Patients With Adenosine Deaminase Severe Combined Immunodeficiency (ADA-SCID)
ClinicalTrials.gov study NCT03478670. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Adenosine on Cranial Hemodynamic, Headache and Migraine Induction Properties.
ClinicalTrials.gov study NCT04577443. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
To Evaluate Adenosine Monophosphate and Allergen Challenge in Allergic Rhinitis
ClinicalTrials.gov study NCT00679250. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Exploring 8-iso Prostaglandin F2α and Adenosine Deaminase Levels in Periodontal Health and Disease
ClinicalTrials.gov study NCT06236555. IPD Sharing: NO. Countries: 1. Publications: 6.
Adenosine 2A Receptor Antagonism and AIH in ALS
ClinicalTrials.gov study NCT05377424. IPD Sharing: NO. Countries: 1. Publications: 5.
Regadenoson and Adenosine
ClinicalTrials.gov study NCT01809743. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Hyperemic Efficacy Between Central and Peripheral Adenosine Infusion for Fractional Flow Reserve (FFR) Measurement
ClinicalTrials.gov study NCT01070420. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Analysis of Adenosine on Sinus and Atrioventricular Nodal Conduction in the Pediatric Transplanted Heart
ClinicalTrials.gov study NCT02462941. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Hyperemic Efficacy Between Nicorandil and Adenosine for Fractional Flow Reserve (FFR) Measurement
ClinicalTrials.gov study NCT01331902. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Differential Effect of Ticagrelor Versus Prasugrel on the Adenosine-induced Coronary Vasodilatory Responses in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
ClinicalTrials.gov study NCT01642966. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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