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1,304 results for “alpha cell”
An Investigation of Tumor Necrosis Factor (TNF)-Alpha in Asthma Using Biopsy Explants and Primary Bronchial Epithelial Cell Cultures
ClinicalTrials.gov study NCT01161303. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic alpha cells
Open the record for dataset details and reuse information.
Data from: Investigation of discriminant metabolites in tamoxifen-resistant and choline kinase-alpha-downregulated breast cancer cells using 1H-nuclear magnetic resonance spectroscopy
Metabolites linked to changes in choline kinase-α (CK-α) expression and drug resistance, which contribute to survival and autophagy mechanisms, are attractive targets for breast cancer therapies. We previously reported that autophagy played a causative role in driving tamoxifen (TAM) resistance of breast cancer cells (BCCs) and was also promoted by CK-α knockdown, resulting in the survival of TAM-resistant BCCs. There is no comparative study yet about the metabolites resulting from BCCs with TAM-resistance and CK-α knockdown. Therefore, the aim of this study was to explore the discriminant metabolic biomarkers responsible for TAM resistance as well as CK-α expression, which might be linked with autophagy through a protective role. A total of 33 intracellular metabolites, including a range of amino acids, energy metabolism-related molecules and others from cell extracts of the parental cells (MCF-7), TAM-resistant cells (MCF-7/TAM) and CK-α knockdown cells (MCF-7/shCK-α, MCF-7/TAM/shCK-α) were analyzed by proton nuclear magnetic resonance spectroscopy (1H-NMRS). Principal component analysis (PCA) and partial least square discriminant analysis (PLS-DA) revealed the existence of differences in the intracellular metabolites to separate the 4 groups: MCF-7 cells, MCF-7/TAM cells, MCF-7-shCK-α cells, and MCF-7/TAM/shCK-α cells. The metabolites with VIP>1 contributed most to the differentiation of the cell groups, and they included fumarate, UA (unknown A), lactate, myo-inositol, glycine, phosphocholine, UE (unknown E), glutamine, formate, and AXP (AMP/ADP/ATP). Our results suggest that these altered metabolites would be promising metabolic biomarkers for a targeted therapeutic strategy in BCCs that exhibit TAM-resistance and aberrant CK-α expression, which triggers a survival and drug resistance mechanism.
The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft-versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant
ClinicalTrials.gov study NCT03805789. IPD Sharing: YES. Countries: 8. Publications: 0.
Capecitabine or 5-FU With Pegylated Interferon Alpha-2b in Unresectable/Metastatic Cutaneous Squamous Cell Carcinoma
ClinicalTrials.gov study NCT02218164. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Polarized Dendritic Cell (aDC1) Based Treatment, Interferon Alpha-2, Rintatolimod, and Celecoxib for the Treatment of HLA-A2+ Refractory Melanoma
ClinicalTrials.gov study NCT04093323. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Glucagon-Like Peptide-1 (GLP-1) Suppression of Alpha Cell Secretion in Type 2 Diabetes Mellitus (T2DM)
ClinicalTrials.gov study NCT00862589. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Dipeptidyl Peptidase-4 Inhibitors and Alpha-cell Recovery
ClinicalTrials.gov study NCT01272583. IPD Sharing: Not stated. Countries: 1. Publications: 0.
TCR Alpha Beta T-cell and CD19 B-cell Depleted Peripheral Blood Stem Cell Transplantation Using the CliniMACS System for Patients With Non-Malignant Hematologic Disorders From Matched or Mismatched, R
ClinicalTrials.gov study NCT03615144. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Ixazomib With Pegylated IFN-alpha 2b (pIFN) in Metastatic Renal Cell Carcinoma (mRCC)
ClinicalTrials.gov study NCT02447887. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Investigation of discriminant metabolites in tamoxifen-resistant and choline kinase-alpha-downregulated breast cancer cells using 1H-nuclear magnetic resonance spectroscopy
Open the record for dataset details and reuse information.
DNase-seq from activated CD4-positive, alpha-beta T cell (ENCSR315WAC)
GEO Series GSE172712. Homo sapiens. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Mint-ChIP-seq from stimulated activated naive CD8-positive, alpha-beta T cell (ENCSR651PFT)
GEO Series GSE209385. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Mint-ChIP-seq from CD8-positive, alpha-beta T cell (ENCSR367EKE)
GEO Series GSE177293. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
microRNA-seq from activated naive CD4-positive, alpha-beta T cell (ENCSR522TYY)
GEO Series GSE219351. Homo sapiens. 2 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Mint-ChIP-seq from activated CD4 positive, naive alpha-beta T cell (ENCSR472BJI)
GEO Series GSE187918. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
intact Hi-C from activated CD4-positive, alpha-beta T cell (ENCSR421CGL)
GEO Series GSE237362. Homo sapiens. 4 samples. Type: Other.
DNase-seq from activated CD4-positive, alpha-beta T cell (ENCSR840QLA)
GEO Series GSE172777. Homo sapiens. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
DNase-seq from activated CD4-positive, alpha-beta T cell (ENCSR696LPC)
GEO Series GSE173004. Homo sapiens. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Mint-ChIP-seq from activated CD4-positive, alpha-beta T cell (ENCSR976IRR)
GEO Series GSE209044. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.