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Dataset results
300 results for “aromatase”
Cannabidiol (CBD) for Treatment of Aromatase Inhibitor-Associated Arthralgias
ClinicalTrials.gov study NCT04754399. IPD Sharing: NO. Countries: 1. Publications: 1.
Vitamin D3 Effects on Musculoskeletal Symptoms With Use of Aromatase Inhibitors
ClinicalTrials.gov study NCT01509079. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Aromatase Inhibitor Growth Study: Letrozole vs. Anastrozole
ClinicalTrials.gov study NCT02137538. IPD Sharing: NO. Countries: 1. Publications: 1.
A Clinical Trial to Assess the Safety of 0.005 % Estriol Vaginal Gel in Hormone Receptor-Positive Postmenopausal Women With Early Stage Breast Cancer in Treatment With Aromatase Inhibitor in the Adjuv
ClinicalTrials.gov study NCT02413008. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Aromatase Inhibitors in Premenopausal Breast Cancer Patients With Chemotherapy-Induced Ovarian Failure
ClinicalTrials.gov study NCT00555477. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of HR+/HER2- Metastatic Breast Cancer Patients Treated With Palbociclib Together With an Aromatase Inhibitor From 2017 to 2023 in Denmark.
ClinicalTrials.gov study NCT06307457. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer
ClinicalTrials.gov study NCT02246621. IPD Sharing: YES. Countries: 22. Publications: 6.
Effect of Bisphosphonate on Bone Loss in Postmenopausal Women With Breast Cancer Initiating Aromatase Inhibitor Therapy
ClinicalTrials.gov study NCT00485953. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Altering Lipids for Tolerance of Aromatase Inhibitor Therapy
ClinicalTrials.gov study NCT04268134. IPD Sharing: NO. Countries: 1. Publications: 2.
Real-World Effectiveness of Palbociclib in Combination With an Aromatase Inhibitor
ClinicalTrials.gov study NCT05361655. IPD Sharing: NO. Countries: 1. Publications: 6.
Comparative Real World Tumor Response in Pre-menopausal Metastatic Breast Cancer Patients Treated With Palbociclib + Aromatase Inhibitor or Aromatase Inhibitor Alone
ClinicalTrials.gov study NCT05012644. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Aromatase Inhibitors on Breast Magnetic Resonance Imaging (MRI)
ClinicalTrials.gov study NCT01129622. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impact of Chemotherapy Followed by Aromatase Inhibitors on Bone Health of Women With ER-positive Early Breast Cancer
ClinicalTrials.gov study NCT01298362. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Letrozole in Breast Cancer Who Have Received 5 Years of Aromatase Inhibitor Therapy
ClinicalTrials.gov study NCT00754845. IPD Sharing: NO. Countries: 2. Publications: 4.
Study of Combined Fulvestrant and Everolimus in Advanced/Metastatic Breast Cancer After Aromatase Inhibitor Failure
ClinicalTrials.gov study NCT00570921. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Assess Effect of 8 Wks of Duloxetine Therapy on Breast Cancer Patients With Aromatase-Inhibitor Associated Pain
ClinicalTrials.gov study NCT01028352. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Brain aromatase and the regulation of sexual activity in male mice
<p>The biologically active estrogen, estradiol, has important roles in adult brain physiology and sexual behavior. A single gene, <i>Cyp19a1</i>, encodes<i> </i>aromatase, the enzyme that catalyzes the conversion of testosterone to estradiol in the testis and brain of male mice. Estradiol formation was shown to regulate sexual activity in various species, but the relative contributions to sexual behavior of estrogen arising in the brain versus gonads remained unclear. To determine the role of brain aromatase in regulating male sexual activity, we generated a brain-specific aromatase knockout (bArKO) mouse. A newly generated whole-body total aromatase knockout mouse of the same genetic background served as a positive control. Here we demonstrate that local aromatase expression and estrogen production in the brain is partially required for male sexual behavior and sex hormone homeostasis. Male bArKO mice exhibited decreased sexual activity in the presence of strikingly elevated circulating testosterone. In castrated adult bArKO mice, administration of testosterone only partially restored sexual behavior; full sexual behavior, however, was achieved only when both estradiol and testosterone were administered together. Thus, aromatase in the brain is, in part, necessary for testosterone-dependent male sexual activity. We also found that brain aromatase is required for negative feedback regulation of circulating testosterone of testicular origin. Our findings suggest testosterone activates male sexual behavior in part via conversion to estradiol in the brain. These studies provide foundational evidence that sexual behavior may be modified through inhibition or enhancement of brain aromatase enzyme activity and/or utilization of selective estrogen receptor modulators.</p>
Sapanisertib in Combination With Fulvestrant in Women With Advanced or Metastatic Breast Cancer After Aromatase Inhibitor Therapy
ClinicalTrials.gov study NCT02756364. IPD Sharing: YES. Countries: 2. Publications: 0.
Study of GDC-0941 or GDC-0980 With Fulvestrant Versus Fulvestrant in Advanced or Metastatic Breast Cancer in Participants Resistant to Aromatase Inhibitor Therapy
ClinicalTrials.gov study NCT01437566. IPD Sharing: Not stated. Countries: 23. Publications: 1.
Effect of Addition of Aromatase Inhibitor to Ovarian Stimulation Therapy in IVF Treatment
ClinicalTrials.gov study NCT02946684. IPD Sharing: NO. Countries: 1. Publications: 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.