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235 results for “bile acid”
Data_Figure S5_Impact on Bile Acid Concentrations by Alveolar Echinococcosis and Treatment with Albendazole in Mice
<p>Data of Figure S5 from Impact on Bile Acid Concentrations by Alveolar Echinococcosis and Treatment with Albendazole in Mice.</p> <p>The Dataset (doi: 10.3390_metabo11070442) contains the original figures as PNG-format (10.3390_metabo11070442_FigS5.PNG). Corresponding raw data and subsequent data analysis obtained from mRNA analysis provided as a file in PDF format (31003A_179400_10.3390_metabo11070442_FJ_AE-bileAcids_1-7.pdf). All further experiment related information provided as one meta-data-file (31003A_179400_10.3390_metabo11070442_FJ_AE-BileAcids_3_4_M_1.txt) in txt format, a file containing further related information in CSV format (31003A_179400_10.3390_metabo11070442_ FJ_AE-BileAcids_3_4_7-10.csv).</p>
Data_Table S2_Impact on Bile Acid Concentrations by Alveolar Echinococcosis and Treatment with Albendazole in Mice
<p>Data of Table S2 from Impact on Bile Acid Concentrations by Alveolar Echinococcosis and Treatment with Albendazole in Mice.</p> <p>The Dataset (doi: 10.3390_metabo11070442) contains the original Table as PNG-format (10.3390_metabo11070442_TabS2.PNG). All further experiment related information provided as one meta-data-file (31003A_179400_10.3390_metabo11070442_FJ_AE-BileAcids_3_4_M_1.txt) in txt format.</p>
Data from: Oral exposure to benzalkonium chlorides in male and female mice reveals sex-dependent alteration of the gut microbiome and bile acid profile
<p>Benzalkonium chlorides (BACs) are commonly used disinfectants in a variety of consumer and food-processing settings, and the COVID-19 pandemic has led to increased usage of BACs. The prevalence of BACs raises the concern that BAC exposure could disrupt the gastrointestinal microbiota, thus interfering with the beneficial functions of the microbes. We hypothesize that BAC exposure can alter the gut microbiome diversity and composition, which will disrupt bile acid homeostasis along the gut-liver axis. In this study, male and female mice were exposed orally to d<sub>7</sub>-C12- and d<sub>7</sub>-C16-BACs at 120 µg/g/day for one week. UPLC-MS/MS analysis of liver, blood, and fecal samples of BAC-treated mice demonstrated the absorption and metabolism of BACs. Both parent BACs and their metabolites were detected in all exposed samples. Additionally, 16S rRNA sequencing was carried out on the bacterial DNA isolated from the cecum intestinal content. For female mice, and to a lesser extent in males, we found that treatment with either d<sub>7</sub>-C12- or d<sub>7</sub>-C16-BAC led to decreased alpha diversity and differential composition of gut bacteria with notably decreased actinobacteria phylum. Lastly, through a targeted bile acid quantitation analysis, we observed decreases in secondary bile acids in BAC-treated mice, which was more pronounced in the female mice. This finding is supported by decreases in bacteria known to metabolize primary bile acids into secondary bile acids, such as the families of Ruminococcaceae and Lachnospiraceae. Together, these data signify the potential impact of BACs on human health through disturbance of the gut microbiome and gut-liver interactions.</p>
Comprehensive clinical and genetic analyses of circulating bile acids and their associations with diabetes and its indices
<p>Files containing source data for "Comprehensive clinical and genetic analyses of circulating bile acids and their associations with diabetes and its indices," by Choucair et al., published in <em>Diabetes</em>.</p>
Trial to Understand Efficacy of Colesevelam in Diarrhea Predominant IBS Patients With Bile Acid Malabsorption
ClinicalTrials.gov study NCT03270085. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy of To Be Marketed (TBM) Cholic Acid Capsules Used to Treat Children With Inborn Errors of Bile Acid Synthesis
ClinicalTrials.gov study NCT01115582. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Effect of the Sequestrant Colesevelam in Bile Acid Diarrhoea
ClinicalTrials.gov study NCT03876717. IPD Sharing: YES. Countries: 1. Publications: 2.
Open Label, Continuation Study of Cholic Acid in Subjects With Inborn Errors of Bile Acid Synthesis
ClinicalTrials.gov study NCT01438411. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Placebo-controlled Study of Volixibat in Subjects With Elevated Serum Bile Acids Associated With Intrahepatic Cholestasis of Pregnancy (OHANA)
ClinicalTrials.gov study NCT04718961. IPD Sharing: Not stated. Countries: 3. Publications: 1.
GlycoCholic Acid Treatment for Patients With Inborn Errors in Bile Acid Synthesis
ClinicalTrials.gov study NCT01589523. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Clinical Studies on Bile Acids in Barrett's Esophagus
ClinicalTrials.gov study NCT00858858. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Ability of Mayo Clinic High-performance Liquid Chromatography (HPLC) Method to Measure Fecal Bile Acids
ClinicalTrials.gov study NCT02111603. IPD Sharing: YES. Countries: 1. Publications: 1.
Ox Bile- Conjugated Bile Acids Sodium in Type II Diabetes Mellitus
ClinicalTrials.gov study NCT02871882. IPD Sharing: NO. Countries: 1. Publications: 1.
The Impact of Different Exercise Modes on Bile Acid Levels and Liver Function in Patients With Non-alcoholic Fatty Liver Disease
ClinicalTrials.gov study NCT06338449. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs)
ClinicalTrials.gov study NCT00706381. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effect of Ileal Bile Acid Transporter Inhibitor in Functional Constipation
ClinicalTrials.gov study NCT01038687. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid
ClinicalTrials.gov study NCT00007020. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Trial of Bile Acid Supplementation in Patients With Multiple Sclerosis
ClinicalTrials.gov study NCT03423121. IPD Sharing: NO. Countries: 1. Publications: 0.
Remedial Mechanism of Simvastatin and Ursodeoxycholic Acid in Liver Cirrhosis: Crosstalk of Bile Secretion, Gut Microbiome, and Host Immune Response
ClinicalTrials.gov study NCT07102979. IPD Sharing: NO. Countries: 1. Publications: 4.
Biliary Excretion of Conjugated Bile Acids in Humans Measured by 11C-cholylsarcosine PET/CT
ClinicalTrials.gov study NCT01879735. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.