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Dataset results
96 results for “biomaterials”
A model of spatio-temporal regulation within biomaterials using DNA reaction–diffusion waveguides
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Data from: Controlled release of basic fibroblast growth factor from a peptide biomaterial for bone regeneration
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Inorganic biomaterials shape the transcriptome profile to induce endochondral differentiation
<div> <p>Minerals play a vital role, working synergistically with enzymes and other cofactors to regulate physiological functions including tissue healing and regeneration. The bioactive characteristics of mineral-based nanomaterials can be harnessed to facilitate in situ tissue regeneration by attracting endogenous progenitor and stem cells and subsequently directing tissue-specific differentiation. Here, we investigate cellular responses of human mesenchymal stem/stromal cells (hMSCs) to traditional bioactive mineral-based nanomaterials, such as hydroxyapatite (nHA), whitlockite (nWH), silicon-dioxide (nSiO<sub>2</sub>), and the emerging synthetic 2D nanosilicates (nSi). We utilized transcriptome sequencing (RNA-seq) to probe the cellular response and determine the significantly affected signaling pathways due to exposure to these inorganic nanomaterials. Transcriptome profiles of stem cells treated with nanosilicates revealed a stabilized skeletal progenitor state suggestive of endochondral differentiation. This observation is bolstered by enhanced deposition of matrix mineralization in nanosilicate treated stem cells compared to control or other treatments. Specifically, use of 2D nanosilicates directs osteogenic differentiation of stem cells via activation of bone morphogenetic proteins (BMP) and hypoxia-inducible factor 1-alpha (HIF-1<span><span>a</span></span>) signaling pathway. This study provides a holistic transcriptomic insight into nanomaterial-cell interactions and predicts downstream effects of nanomaterial induction of endochondral differentiation.</p> </div>
Development of an automated biomaterial platform to study mosquito feeding behavior
<p>Mosquitoes carry a number of deadly pathogens that are transmitted while feeding on blood through the skin, and studying mosquito feeding behavior could elucidate countermeasures to mitigate biting. Although this type of research has existed for decades, there has yet to be a compelling example of a controlled environment to test the impact of multiple variables on mosquito feeding behavior. In this study, we leveraged uniformly bioprinted vascularized skin mimics to create a high-throughput mosquito feeding platform with independently tunable feeding sites. Our platform allows us to observe mosquito feeding behavior and collect video data for 30-45 minutes while collecting video data. We maximized throughput by developing a highly accurate computer vision model (mean average precision: 92.5%) that automatically processes videos and increases measurement objectivity. This model enables assessment of critical factors such as feeding and activity around feeding sites, and we used it to evaluate the repellent effect of DEET and oil of lemon eucalyptus-based repellents. Our resultsWe validatedshow that both repellents effectively repel mosquitoes in laboratory settings (0% feeding in experimental groups, 13.8% feeding in control group, p<0.0001), validating suggesting our platform’s use as a repellent screening assay in the future. The platform is scalable, compact, and reduces dependence on vertebrate hosts in mosquito research.</p>
Visual inspection of the coagulation of the CS-PRP-FIIa biomaterial rehydrated in sheep PRP
<p>This video shows the coagulation of the CS-PRP-FIIa biomaterial rehydrated in sheep PRP when placed in a plastic weighing boat. The video shows the coagulation state after 0, 2.5 and 5 minutes for the 4 analyzed thrombin concentrations (0, 0.25, 0.5 and 1.0 NIH/mL).</p>
Comparison of Phicogenic vs. Xenogeneic Biomaterial for Maxillary Sinus Floor Elevation
ClinicalTrials.gov study NCT03682315. IPD Sharing: NO. Countries: 1. Publications: 4.
Evaluation of Efficacy and Safety of Autologous MSCs Combined to Biomaterials to Enhance Bone Healing
ClinicalTrials.gov study NCT01842477. IPD Sharing: Not stated. Countries: 4. Publications: 2.
Evaluation of Bone Preservation After Molar Extraction Using Photobiomodulation Combined With Biomaterial Grafting
ClinicalTrials.gov study NCT06164626. IPD Sharing: YES. Countries: 1. Publications: 73.
Clinical Evaluation and Cone Beam Computed Tomography Analysis of Different Biomaterials for Apexogenesis of Immature Permanent Molars
ClinicalTrials.gov study NCT07336498. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparative Evaluation of Calcium Silicate-doped Treated Dentin Matrix and Mineral Trioxide Aggregate as Miniature Pulpotomy Biomaterials in Deep Carious Lesions
ClinicalTrials.gov study NCT07302438. IPD Sharing: NO. Countries: 1. Publications: 1.
In Vivo Clinical Trial of Porous Starch - Hydroxyapatite Composite Biomaterials for Bone Regeneration
ClinicalTrials.gov study NCT02910232. IPD Sharing: YES. Countries: 1. Publications: 3.
Clinical AML Registry and Biomaterial Database of the Study Alliance Leukemia (SAL)
ClinicalTrials.gov study NCT03188874. IPD Sharing: NO. Countries: 1. Publications: 3.
The Mechanism of Melanocyte Self-Assembly on Biomaterials and the Functional Analysis
ClinicalTrials.gov study NCT00509314. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of Alveolar Bone Preservation Using Photobiomodulation Combined With Grafting With Scaffold Biomaterial
ClinicalTrials.gov study NCT06150456. IPD Sharing: Not stated. Countries: 1. Publications: 70.
Biomaterials and Mesenchymal Stem/Stromal Cells in the Treatment of Knee Articular Surface Lesions
ClinicalTrials.gov study NCT06078072. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Treatment of Peri-implantitis Lesions by Using Biomaterial
ClinicalTrials.gov study NCT02375750. IPD Sharing: NO. Countries: 1. Publications: 2.
A Comparative Study of 2 Doses of BM Autologous H-MSC+Biomaterial vs Iliac Crest AutoGraft for Bone Healing in Non-Union
ClinicalTrials.gov study NCT03325504. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Use of Biomaterials as Desensitizer Agents
ClinicalTrials.gov study NCT02770573. IPD Sharing: NO. Countries: 1. Publications: 2.
Efficacy in Alveolar Bone Regeneration With Autologous MSCs and Biomaterial in Comparison to Autologous Bone Grafting
ClinicalTrials.gov study NCT04297813. IPD Sharing: YES. Countries: 4. Publications: 3.
Nanodiamond-Gutta Percha Composite Biomaterials for Root Canal Therapy
ClinicalTrials.gov study NCT03376984. IPD Sharing: NO. Countries: 1. Publications: 2.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.