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ShareScore release 0.9.0
Dataset results
360 results for “carcinogenesis”
Non-targeted effects of low dose ionizing radiation act via TGF-beta to promote mammary carcinogenesis
This is a genome-wide approach to identifying genes persistently induced in the mouse mammary gland by acute whole body low dose ionizing radiation (10cGy) 1 and 4 weeks after exposure. Gene expression that is modified under these parameters were compared between Tgfb1 wild type and heterozygote littermates in order to determine which genes induced or repressed by radiation were mediated via Tgfb1 status. Differential gene expression was analyzed in Tgfb1 heterozygote and wild type littermate 4th mammary glands after whole body exposure to an acute dose of 10cGy ionizing radiation. Estrus cycle was normalized in all mice two days prior to irradiation by injection with an estrogen and progesterone mixture. It is widely believed that the carcinogenic action of ionizing radiation is due to targeted DNA damage and resulting mutations but there is also substantial evidence that non-targeted radiation effects alter epithelial phenotype and the stromal microenvironment. Activation of transforming growth factor beta 1 (TGFbeta) is a non-targeted radiation effect that mediates cell fate decisions following DNA damage and regulates microenvironment composition; it could either suppress or promote cancer. Gene expression profiling shown herein demonstrates that low dose radiation (10 cGy) elicits persistent changes in Tgfb1 wild type and heterozygote murine mammary gland that are highly modulated by TGFbeta. We asked if such non-targeted radiation effects contribute to carcinogenesis by using a novel radiation chimera model. Unirradiated Trp53 null mammary epithelium was transplanted to the mammary stroma of mice previously exposed to a single low (10 -100 cGy) radiation dose. By 300 days 100% of transplants in irradiated hosts at either 10 or 100 cGy had developed Trp53 null breast carcinomas compared to 54% in unirradiated hosts. Tumor growth rate was also increased by high but not low dose host irradiation. In contrast irradiation of Tgfb1 heterozygote mice prior to transplantation failed to decrease tumor latency or increase growth rate at any dose. Host irradiation significantly reduced the latency of invasive ductal carcinoma compared to spindle cell carcinoma as well as those tumors negative for smooth muscle actin in wild type but not Tgfb1 heterozygote mice. However irradiation of either host genotype significantly increased the frequency of estrogen receptor negative tumors. These data demonstrate two concepts critical to understanding radiation risks. First non-targeted radiation effects can significantly promote the frequency and alter the features of epithelial cancer. Second radiation-induced TGFbeta activity is a key mechanism of tumor promotion. Keywords: Differential gene expression after low dose irradiation Two genotypes: TGBbeta1 heterozygote and wildtype mouse mammary glands. Two time points post-10cGy-irradiation per genotype (1 week 4 weeks); control time point was 1 week post-sham-irradiation. Two or three replicates per time point.
Smad4 restricts injury-provoked biliary proliferation and carcinogenesis (AKPS_EV_vs_Smad4_RNAseq)
GEO Series GSE237679. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Smad4 restricts injury-provoked biliary proliferation and carcinogenesis (Smad4_floxed_vs_WT_RNAseq)
GEO Series GSE237678. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
A C/EBPα–Wnt connection in gut homeostasis and carcinogenesis
GEO Series GSE123925. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
HACE1 prevents lung carcinogenesis via inhibition of RAC-family GTPases
GEO Series GSE149137. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
miR-193a-3p is a key tumor-suppressor in ulcerative colitis-associated colon cancer and promotes carcinogenesis through regulation of IL17RD.
GEO Series GSE68306. Homo sapiens. 45 samples. Type: Expression profiling by array; Other.
A distinct mechanism of epigenetic reprogramming silences PAX2 and initiates endometrial carcinogenesis
GEO Series GSE275320. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Helicobacter pylori-mediated Epigenetic Dysregulation of FOXD3 Tumor-suppressive Cascade In Gastric Carcinogenesis [ChIP]
GEO Series GSE39490. Homo sapiens; Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by genome tiling array; Methylation profiling by genome tiling array.
Molecular characterization of 4-NQO induced F344 rat tongue carcinogenesis: alteration of multiple gene expression and hypomethylation of PTGS2 proximal promoter
GEO Series GSE51125. Rattus norvegicus. 22 samples. Type: Expression profiling by array.
Aerobic exercise effects on tumor and skeletal muscle transcriptome in a DMBA-induced carcinogenesis
GEO Series GSE299413. Rattus norvegicus. 20 samples. Type: Expression profiling by high throughput sequencing.
GPNMB+Gal-3+ Hepatic Parenchymal Cells Promote Immunosuppressive Microenvironment Formation and Hepatocellular Carcinogenesis
GEO Series GSE218561. Rattus norvegicus. 7 samples. Type: Expression profiling by high throughput sequencing.
Dysregulation of mRNA expression by miR-186 overexpression in arsenic-induced skin carcinogenesis
GEO Series GSE276586. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
MiR-196b is epigenetically silenced during the pre-malignant stage of lung carcinogenesis
GEO Series GSE79987. Homo sapiens. 4 samples. Type: Expression profiling by array.
Loss of colonic primary cilia promotes inflammation and carcinogenesis.
GEO Series GSE207877. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Age and Space Irradiation Modulate Tumor Progression: Implications for Carcinogenesis Risk
GEO Series GSE45606. Mus musculus. 36 samples. Type: Expression profiling by array.
Microbial activities associated with human intestinal mucosal biofilms change mRNAs and microRNAs to promote carcinogenesis in mice [miRNA]
GEO Series GSE108164. Mus musculus. 21 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Normalizing body weight with a dietary strategy mitigates obesity-accelerated pancreatic carcinogenesis in mice
GEO Series GSE293790. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Dual role of GRHL3 in bladder carcinogenesis is associated with histological subtypes
GEO Series GSE241298. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Gene expression dynamics in fibroblasts during early-stage murine pancreatic carcinogenesis
GEO Series GSE270121. Mus musculus. 34 samples. Type: Expression profiling by high throughput sequencing.
Acetylation of spliceosome protein PHF5A modulates stress responses and colorectal carcinogenesis through alternative splicing mediated upregulation of KDM3A
GEO Series GSE122761. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.