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1,052 results for “cardiomyocytes”
The mRNA expression changes in neonatal primary mouse ventricular cardiomyocytes treated with epirubicin (2uM)
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Induced pluripotent stem cell-derived cardiomyocyte in vitro models: tissue fabrication protocols, assessment methods, and quantitative maturation metrics for benchmarking progress
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Data from: Major group-B enterovirus populations deleted in the noncoding 5' region of genomic RNA modulate activation of the type I interferon pathway in cardiomyocytes and induce myocarditis
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Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia
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Increased Drp1 acetylation by lipid overload induces cardiomyocyte death and heart dysfunction
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Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte
<p>Aging-associated diseases, including cardiac dysfunction, are increasingly common in the population. However, the mechanisms of physiologic aging in general, and cardiac aging in particular, remain poorly understood. Age-related heart impairment is lacking a clinically effective treatment. Using the model of naturally aging mice and rats, we show direct evidence of increased proton leak in the aged heart mitochondria. Moreover, our data suggested ANT1 as the most likely site of mediating increased mitochondrial proton permeability in old cardiomyocytes. Most importantly, the tetra-peptide SS-31 prevents age-related excess proton entry, decreases the mitochondrial flash activity and mitochondrial permeability transition pore opening, rejuvenates mitochondrial function by direct association with ANT1 and the mitochondrial ATP synthasome, and leads to substantial reversal of diastolic dysfunction. Our results uncover the excessive proton leak as a novel mechanism of age-related cardiac dysfunction and elucidate how SS-31 is able to reverse this clinically important complication of cardiac aging.</p>
A targeted metabolomics-based assay using human induced pluripotent stem cell-derived cardiomyocytes identifies structural and functional cardiotoxicity potential
<p>Implementing screening assays that identify functional and structural cardiotoxicity earlier in the drug development pipeline has the potential to improve safety and the cost and time required to bring new drugs to market. In this study, a metabolic biomarker-based assay was developed that predicts the cardiotoxicity potential of a drug based on changes in the metabolism and viability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM). Assay development and testing was conducted in two phases: (1) biomarker identification and (2) targeted assay development. In the first phase, metabolomic data from hiPSC-CM spent media following exposure to 66 drugs was used to identify biomarkers that identified both functional and structural cardiotoxicants. Four metabolites that represent different metabolic pathways (arachidonic acid, lactic acid, 2'-deoxycytidine, and thymidine) were identified as indicators of cardiotoxicity. In phase two, a targeted, exposure-based biomarker assay was developed that measured these metabolites and hiPSC-CM viability across an eight-point concentration curve. Metabolite-specific predictive thresholds for identifying the cardiotoxicity potential of a drug were established and optimized for balanced accuracy or sensitivity. When predictive thresholds were optimized for balanced accuracy, the assay predicted the cardiotoxicity potential of 81 drugs with 86% balanced accuracy, 83% sensitivity, and 90% specificity. Alternatively, optimizing the thresholds for sensitivity yields a balanced accuracy of 85%, 90% sensitivity, and 79% specificity. This new hiPSC-CM-based assay provides a paradigm that can identify structural and functional cardiotoxic drugs that could be used in conjunction with other endpoints to provide a more comprehensive evaluation of a drug's cardiotoxicity potential.</p>
time course gene expression of atrial cardiomyocyte differentiation
<p>atrial cardiomyocyte protocol was similar to that described by Cyganek et al. 2018</p>
2D Monolayer Cardiomyocytes of Healthy control individual differentiated from iPSC
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Fibroblast Growth Factor receptor signaling in cardiomyocytes is protective in the acute phase following ischemia-reperfusion injury
<p>Suplemental echocardiographic images</p>
Cardiomyocyte timelapse videos
<p>Supplementary videos for PhD Thesis " Remote Refocusing light-sheet fluorescence microscopy for high-speed 2D and 3D imaging of calcium dynamics in cardiomyocytes" at Imperial College London. <br> The videos included are the following: <br> 1. Video 4.3: 2D LSFM timelapse of calcium transients and sparks in a cardiomyocyte.<br> 2. Video 5.5: 3D LSFM timelapse of hiPSC-CM undergoing spontaneous calcium transients.<br> 3. Video 5.6: Widefield transillumination timelapse of hiPSC-CM and adult-CM co-culture.<br> 4. Video 5.7: Widefield epifluorescence timelapse of hiPSC-CM and adult-CM co-culture<br> 5. Video 5.8: 3D LSFM timelapse of synchronized transients in hiPSC-CM and adult-CM co-culture.<br> 6. Video 5.10a: 3D LSFM timelapse of hiPSC-CM and adult-CM co-culture, without NBleb.<br> 7. Video 5.10b: 3D LSFM timelapse of hiPSC-CM and adult-CM co-culture, with NBleb.<br> 8. Video 5.11: 3D LSFM timelapse of live myocardial slices undergoing stimulated contraction.</p>
Gene Expression, Metabolic Data, and Protein Expression in Angiotensin II-Stimulated Cardiomyocytes: A Comprehensive Dataset
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Hypoosmotic solutions affecting a monolayer of neonatal rat ventricular cardiomyocytes
<p><span>Live cell imaging was conducted with </span><span>Image ExFluorer (Live Cell Instrument, South Korea) </span><span>with an integrated environmental control system including CO</span><span><span>2</span></span><span>, O</span><span><span>2</span></span><span>, humidity control and temperature. The prepared samples were placed in 1T solution in the incubator system at 37°C and 5% CO</span><span><span>2</span></span><span>. Images were taken every 1 minute for 90 minutes with a phase contrast plan semi-apochromatic correction 10x objective (Nikon Instruments, Japan) and 5.5MP sCMOS camera (Nikon Instruments, Japan). After 5 minutes of incubation in 1T solution, the solution was changed to 0.75T or 0.5T. No external stimulation was used in order to stop the spontaneous contraction and register only changes in cell volume. </span></p>
HD-MEA extracellular measurements of iPSC-derived cardiomyocytes
<p>Human iPSC-derived cardiomyocytes (short QT syndrome).</p> <p>Extracellular measurements obtained using high-density microelectrode arrays.</p> <p> </p> <p>Ethics statement: The generation of iPSCs was approved by the Ethics Committee of the University Medical Center Göttingen in Germany (approval number: 10/9/15) and carried out in accordance with the approved guidelines. Written informed consent was obtained from all participants or their legal representatives prior to participation in the study.</p> <p> </p>
HD-MEA intracellular-like measurements of iPSC-derived cardiomyocytes
<p>Human iPSC-derived cardiomyocytes (iCell Cardiomyocytes).</p> <p>Intracellular-like measurements obtained using high-density microelectrode arrays.</p>
Multi-omics analysis reveals attenuation of cellular stress by Empagliflozin in High Glucose-treated human cardiomyocytes.
<p>Mass spectrometry raw data for the manuscript <strong>Multi-omics analysis reveals attenuation of cellular stress by Empagliflozin in High Glucose-treated human cardiomyocytes.</strong></p>
DNA Analysis From Isolated Cardiomyocytes in the Molecular Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
ClinicalTrials.gov study NCT03177018. IPD Sharing: NO. Countries: 1. Publications: 1.
Ultrastructural Characteristics of Mitochondria in Cardiomyocytes in Heart Failure
ClinicalTrials.gov study NCT05770349. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Characterization of Myocardial Interstitial Fibrosis and Cardiomyocyte Hypertrophy by Cardiac MRI in Heart Failure
ClinicalTrials.gov study NCT03084679. IPD Sharing: NO. Countries: 1. Publications: 43.
Modeling and Pharmacological Targeting of Genetic Cardiomyopathy in Children Via Cardiomyocytes Derived From Induced Pluripotent Stem Cells (DMDstem)
ClinicalTrials.gov study NCT03696628. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.