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Dataset results
47 results for “chemical probe”
Fig. 6 in Intramolecular transesterification of depsides yields fluorescent 1H-isochromen-1-ones: Application as a chemical probe for lichen determination
Fig. 6. UV and fluorescence spectra of the isochromen-1-ones 9 and 11.
Single-molecule microscopy (SiM-KARTS) and chemical probing (SHAPE) of lncRNA
Open the record for dataset details and reuse information.
Identification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [LS-174-T]
GEO Series GSE67846. Homo sapiens. 9 samples. Type: Expression profiling by array.
DMS-MaPseq chemical probing of pri-miRNA and human mRNA segments
GEO Series GSE262014. synthetic construct. 33 samples. Type: Other.
Probing the signaling requirements for naïve human pluripotency by high-throughput chemical screening
GEO Series GSE153215. Homo sapiens. 33 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Identification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [beta-catenin organoids]
GEO Series GSE67847. Mus musculus. 21 samples. Type: Expression profiling by array.
Carbodiimide reagents for the chemical probing of RNA structure in cells
GEO Series GSE118309. Homo sapiens; Mus musculus. 42 samples. Type: Other.
GSK8814: a chemical probe fort he ATAD2 bromodomain
GEO Series GSE78868. Homo sapiens. 12 samples. Type: Expression profiling by array.
Identification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [Colo205]
GEO Series GSE67845. Homo sapiens. 16 samples. Type: Expression profiling by array.
Probing the signaling requirements for naïve human pluripotency by high-throughput chemical screening [WGBS]
GEO Series GSE153213. Homo sapiens. 12 samples. Type: Methylation profiling by high throughput sequencing.
Chemical potentiator of copper-accumulation and -toxicity: Probing iron- regulons of Saccharomyces cerevisiae
GEO Series GSE54045. Saccharomyces cerevisiae. 18 samples. Type: Expression profiling by high throughput sequencing.
Interpreting reverse transcriptase termination and mutation events for greater insight into the chemical probing of RNA
GEO Series GSE97609. Mus musculus. 20 samples. Type: Other.
Probing the signaling requirements for naïve human pluripotency by high-throughput chemical screening [RNA-seq]
GEO Series GSE153212. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Genetically Encoded Supramolecular Targeting of Fluorescent Membrane Tension Probes within Live Cells: Precisely Localized Controlled Release by External Chemical Stimulation
<p>Original data. Second part at </p> <pre>https://doi.org/10.5281/zenodo.4322986</pre>
Niclosamide as a chemical probe for analyzing SARS-CoV-2 modulation of host cell lipid metabolism
<p>SARS-CoV-2 subverts host cell processes to facilitate rapid replication and dissemination, and this leads to pathological inflammation. We used niclosamide (NIC), a poorly soluble anti-helminth drug identified for repurposed treatment of COVID-19, which activates the cells' autophagic and lipophagic processes as a chemical probe to determine if it can modulate the host cell's total lipid profile that would otherwise be either amplified or reduced during SARS-CoV-2 infection. Through parallel lipidomic and transcriptomic analyses we observed massive reorganization of lipid profiles of SARS-CoV-2 infected Vero E6 cells, especially with triglycerides, which were elevated early during virus replication, but decreased thereafter, as well as plasmalogens, which were elevated at later timepoints during virus replication, but were also elevated under normal cell growth. These findings suggested a complex interplay of lipid profile reorganization involving plasmalogen metabolism. We also observed that NIC treatment of both low and high viral loads does not affect virus entry. Instead, NIC treatment reduced the abundance of plasmalogens, diacylglycerides, and ceramides, which we found elevated during virus infection in the absence of NIC, resulting in a significant reduction in the production of infectious virions. Unexpectedly, at higher viral loads, NIC treatment also resulted in elevated triglyceride levels, and induced significant changes in phospholipid metabolism. We posit that future screens of approved drugs should prioritize compounds that effectively counter SARS-CoV-2 subversion of lipid metabolism, thereby reducing virus replication, egress, and the subsequent regulation of key lipid mediators of pathological inflammation.</p>
Identification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease
GEO Series GSE67849. Mus musculus; Homo sapiens. 46 samples. Type: Expression profiling by array.
A Chemical Probe Based on the PreQ1 Metabolite Enables Transcriptome-wide Mapping of Binding Sites
GEO Series GSE168353. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Template switching enables chemical probing of native RNA structures
GEO Series GSE274121. Listeria monocytogenes. 18 samples. Type: Other.
Fingerprinting tertiary structure in complex RNAs using single-molecule correlated chemical probing
GEO Series GSE278422. Enterococcus faecalis. 15 samples. Type: Other.
Niclosamide as a chemical probe for analyzing SARS-CoV-2 modulation of host cell lipid metabolism
GEO Series GSE178157. Chlorocebus sabaeus. 26 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.