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351 results for “cognitive decline”
Genetic variants beyond amyloid and tau associated cognitive decline: a cohort study
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Data for: General cognitive performance declines with female age and is negatively related to fledging success in a wild bird
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Leukotriene A4 hydrolase inhibition improves age related cognitive decline via modulation of synaptic function (Part 1/2)
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The insidious degeneration of white matter and cognitive decline in Fabry disease
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An investigation of antihypertensive class, dementia, and cognitive decline
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Predictive biomarkers of individual trajectories in elderly persons with subtle cognitive decline: APOE genotype data
<p>The mentalizing network (MN) treats social interactions based on our understanding of other people's intentions and includes the medial prefrontal cortex (mPFC), temporoparietal junction (TPJ), posterior cingulate cortex (PCC), precuneus (PC) and amygdala. Not all elders are equally affected by the aging-related decrease of mentalizing abilities. Personality has recently emerged as a strong determinant of functional connectivity in MN areas. However, its impact on volumetric changes across the mentalizing network in brain aging is still unknown. To address this issue, we explored the determinants of volume decrease in MN components including amyloid burden, personality, and APOE genotyping in a previously established cohort of 130 healthy elders with a mean follow-up of 54 months. Personality was assessed with the Neuroticism Extraversion Openness Personality Inventory-Revised. Regression models corrected for multiple comparisons were used to identify predictors of volume loss including time, age, sex, personality, amyloid load, presence of APOE epsilon 4 allele and cognitive evolution. In cases with higher Agreeableness scores, there were lower volume losses in posterior cingulate cortex (PCC), precuneus (PC) and amygdala bilaterally. This was also the case for right medial prefrontal cortex (mPFC) in elders displaying lower Agreeableness and Conscientiousness. In multiple regression models, the effect of Agreeableness was still observed in left PC and right amygdala and that of Conscientiousness in right mPFC volume loss (26.3% of variability, significant age, sex). Several Agreeableness (Modesty) and Conscientiousness (order, dutifulness, achievement striving and self-discipline) facets were positively related to increased volume loss in cortical components of the MN. In conclusion, these data challenge the beneficial role of higher levels of Agreeableness and Conscientiousness in old age showing that they are associated with an increased rate of volume loss within the mentalizing network.</p>
Long-term dietary flavonoid intake and subjective cognitive decline in US men and women
<p><b>Objective:</b> To prospectively examine the associations between long-term dietary flavonoids and subjective cognitive decline (SCD).</p> <p><b>Methods:</b><b> </b>We followed 49,493 women from the Nurses' Health Study (NHS) (1984-2006) and 27,842 men from the Health Professionals Follow-up Study (HPFS) (1986-2002). Poisson regression was used to evaluate the associations between dietary flavonoids (flavonols, flavones, flavanones, flavan-3-ols, anthocyanins, polymeric flavonoids, and proanthocyanidins) and subsequent SCD. For the NHS, long-term average dietary intake was calculated from seven repeated food frequency questionnaires (SFFQs), and SCD was assessed in 2012 and 2014. For the HPFS, average dietary intake was calculated from five repeated SFFQs, and SCD assessed in 2008 and 2012.</p> <p><b>Result</b><b>s: </b>Higher intake of total flavonoids was associated with lower odds of SCD after adjusting for age, total energy intake, major non-dietary factors, and specific dietary factors. Comparing the highest versus the lowest quintiles of total flavonoid intake, the pooled multivariable-adjusted odds ratios (ORs) (95% CIs) of 3-unit increments in SCD was 0.81 (0.76, 0.89). In the pooled results, the strongest associations were observed for flavones (OR=0.62 [0.57, 0.68]), flavanones (0.64 [0.58, 0.68)]), and anthocyanins (0.76 [0.72, 0.84]) (<i>p</i> trend <0.0001 for all groups). The dose-response curve was steepest for flavones, followed by anthocyanins. Many flavonoid-rich foods, such as strawberries, oranges, grapefruits, citrus juices, apples/pears, celery, peppers, and bananas, were significantly associated with lower odds of SCD.</p> <p><b>Conclusion: </b>Our findings support a benefit of higher flavonoid intakes for maintaining cognitive function in US men and women.<b> </b></p>
ATN-classification and clinical progression in subjective cognitive decline: the SCIENCe project
<p>Objective: To investigate the relationship between the ATN-model and risk of dementia and cognitive decline in individuals with subjective cognitive decline (SCD).</p> <p>Methods: We classified 693 participants with SCD (60±9yr, 41%F, MMSE 28±2) from the Amsterdam Dementia Cohort and SCIENCe project according to the ATN-model, as determined by amyloid PET or CSF Abeta (A), CSF p-tau (T) and MRI-based medial temporal lobe atrophy (N). All underwent extensive neuropsychological assessment. For 342 participants follow-up was available (3±2yr). As a control population, we included 124 participants without SCD.</p> <p>Results: 56% (n=385) participants had <i>normal AD biomarkers </i>(A-T-N-), 27% (n=186) had <i>non-AD pathologic change</i> (A-T-N+, A-T+N-, A-T+N+), 18% (n=122) fell within the <i>Alzheimer's continuum </i>(A+T-N-, A+T-N+, A+T+N-, A+T+N+). ATN profiles were unevenly distributed, with A-T+N+, A+T-N+ and A+T+N+ containing very few participants. Cox regression showed that compared to A-T-N-, participants in A+ profiles had a higher risk of dementia with a dose-response pattern for number of biomarkers affected. Linear mixed models showed participants in A+ profiles showed a steeper decline on tests addressing memory, attention, language, and executive functions. In the control group, there was no association between ATN and cognition.</p> <p>Conclusions: Among individuals presenting with SCD at a memory clinic, those with a biomarker profile A-T+N+, A+T-N-, A+T+N- and A+T+N+ were at increased risk of dementia, and showed steeper cognitive decline compared to A-T-N- individuals. These results suggest a future where biomarker results could be used for individualized risk profiling in cognitively normal individuals presenting at a memory clinic.</p>
Supplemental Materials: Duration of poverty and subsequent cognitive function and decline among older adults in China, 2005-2018
<p><b>Objective</b></p> <p>To investigate the relationship between late-life duration of poverty exposure and cognitive function and decline among older adults in China.</p> <p><b>Methods</b></p> <p>Data were from 3,209 participants aged ≥64 in the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Duration of poverty, defined according to urban and rural regional standards from the China Statistical Yearbook, was assessed from 2005-2011 (never in poverty; 1/3 of the period in poverty; ≥2/3 of the period in poverty). Cognitive function was measured by the Chinese Mini Mental State Exam (CMMSE) from 2011 to 2018. We used attrition-weighted, multivariable <span>mixed-effects Tobit regression to examine the association of duration of poverty with cognitive performance and rate of decline. </span></p> <p><b>Results</b></p> <p>A total of 1,162 individuals (36.21%) were never in poverty over the period from 2005 to 2011, 1,172 (36.52%) were in poverty 1/3 of the period, and 875 (27.27%) were in poverty ≥2/3 of the period. A longer poverty duration was associated with lower subsequent CMMSE scores with a dose-response relationship (1/3 vs. never in poverty: β = -0.98; 95% CI: -1.61 to -0.35; ≥2/3 vs. never in poverty: β = -1.55; 95% CI: -2.29 to -0.81). However, a longer duration of poverty was associated with a slower rate of CMMSE score decline over time.</p> <p><b>Conclusion</b></p> <p>These findings provide valuable evidence on the role of cumulative late-life poverty in relation to cognitive health among older adults in a rapidly urbanizing and aging middle-income country. Our findings may support a <i>compensation </i>hypothesis for cognitive reserve in this setting.</p>
PhytoSERM to Prevent Menopause Associated Decline in Brain Metabolism and Cognition
ClinicalTrials.gov study NCT05664477. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Influence of Cognitive Decline on Quality of Life After Coronary Bypass
ClinicalTrials.gov study NCT03774342. IPD Sharing: NO. Countries: 1. Publications: 25.
Do Apolipoprotein E Polymorphisms Influence Risk of Cognitive Decline by Modulating Omega-3 Fatty Acid Metabolism?
ClinicalTrials.gov study NCT01577004. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vitamin B12 Supplement to Prevent Cognitive Decline
ClinicalTrials.gov study NCT02457507. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Support for Caregivers of Older Adults With Cognitive Decline
ClinicalTrials.gov study NCT04787068. IPD Sharing: UNDECIDED. Countries: 1. Publications: 9.
Predictors Of Cognitive Decline Using Digital Devices
ClinicalTrials.gov study NCT07051408. IPD Sharing: YES. Countries: 1. Publications: 1.
Predictors of Cognitive Decline in Normal Aging
ClinicalTrials.gov study NCT00094939. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders: Proof-of-concept
ClinicalTrials.gov study NCT06914284. IPD Sharing: UNDECIDED. Countries: 1. Publications: 15.
Interventions to Attenuate Cognitive Decline: Keys to Staying Sharp
ClinicalTrials.gov study NCT03528486. IPD Sharing: NO. Countries: 1. Publications: 2.
TEsting METformin Against Cognitive Decline in HD
ClinicalTrials.gov study NCT04826692. IPD Sharing: NO. Countries: 1. Publications: 36.
Brain Health Program for Older Adults With Subjective Cognitive Decline
ClinicalTrials.gov study NCT05934136. IPD Sharing: NO. Countries: 1. Publications: 4.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.