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ShareScore release 0.9.0
Dataset results
92 results for “complexity of infection”
Single-stage Surgery With Antibiotic-loaded Hydrogel Coated Implants Versus Two Stage Surgery for Secondary Prevention of Complex Chronic Periprosthetic Hip Joint Infection
ClinicalTrials.gov study NCT04251377. IPD Sharing: NO. Countries: 1. Publications: 1.
A Randomized, Double-Blinded, Placebo-Controlled, Phase II Inhaled Interferon Gamma-1b and Antimycobacterials to Treat Pulmonary Mycobacterium Avium Complex Infections
ClinicalTrials.gov study NCT00021567. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Adjuvant Cytokine Therapy to Treat Pulmonary Mycobacterium Avium Complex Infection
ClinicalTrials.gov study NCT00111397. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Safety and Effectiveness of Clarithromycin and Rifabutin Used Alone or in Combination to Prevent Mycobacterium Avium Complex (MAC) or Disseminated MAC Disease in HIV-Infected Patients
ClinicalTrials.gov study NCT00001030. IPD Sharing: Not stated. Countries: 2. Publications: 7.
Subcutaneously Administered Interleukin-12 Therapy in HIV-Infected Patients With Disseminated Mycobacterium Avium Complex Infection
ClinicalTrials.gov study NCT00001763. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Pathogen burden, co-infection and major histocompatibility complex variability in the European badger (Meles meles)
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Data from: Manipulating virulence factor availability can have complex consequences for infections
Given the rise of bacterial resistance against antibiotics, we urgently need alternative strategies to fight infections. Some propose we should disarm rather than kill bacteria, through targeted disruption of their virulence factors. It is assumed that this approach (i) induces weak selection for resistance because it should only minimally impact bacterial fitness, and (ii) is specific, only interfering with the virulence factor in question. Given that pathogenicity emerges from complex interactions between pathogens, hosts, and their environment, such assumptions may be unrealistic. To address this issue in a test case, we conducted experiments with the opportunistic human pathogen Pseudomonas aeruginosa, where we manipulated the availability of a virulence factor, the iron-scavenging pyoverdine, within the insect host Galleria mellonella. We observed that pyoverdine availability was not stringently predictive of virulence, and affected bacterial fitness in non-linear ways. We show that this complexity could partly arise because pyoverdine availability affects host responses and alters the expression of regulatorily linked virulence factors. Our results reveal that virulence-factor manipulation feeds back on pathogen and host behavior, which in turn affects virulence. Our findings highlight that realizing effective and evolutionarily robust anti-virulence therapies will ultimately require deeper engagement with the intrinsic complexity of host-pathogen systems.
Single-cell profiling of complex plant responses to pathogen infection
<p>Original images for figures and quantifications. </p>
A Randomized Controlled Prophylactic Study of Clofazimine To Prevent Mycobacterium Avium Complex Infection in HIV Disease
ClinicalTrials.gov study NCT00002058. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of Interferon-Gamma in the Complex Treatment of Patients Infected With HIV and Tuberculosis
ClinicalTrials.gov study NCT05065905. IPD Sharing: NO. Countries: 1. Publications: 0.
Prevalance Of Helicobacter Pylori Infection In Chonic Kidney Diseased Patient Admitted To Luxor Medical Complex
ClinicalTrials.gov study NCT06371001. IPD Sharing: NO. Countries: 0. Publications: 4.
The Effects of Treatment for Mycobacterium Avium Complex (MAC) on the Cells of HIV-Infected Patients
ClinicalTrials.gov study NCT00000860. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Dextran Sulfate in HIV-Infected Patients and in Patients With AIDS or AIDS Related Complex (ARC)
ClinicalTrials.gov study NCT00001009. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination With Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs
ClinicalTrials.gov study NCT00002140. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Safety and Effectiveness of Clarithromycin Plus Zidovudine or Dideoxyinosine in the Treatment of Mycobacterium Avium Complex (MAC) Infections in Children With AIDS
ClinicalTrials.gov study NCT00000971. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Manipulating virulence factor availability can have complex consequences for infections
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Data from: Major histocompatibility complex selection dynamics in pathogen-infected túngara frog (Physalaemus pustulosus) populations
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Data from: The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea
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LncRNA RVRL1 restricts rabies virus infection by disrupting PRC2 complex [RNA-seq]
GEO Series GSE107277. Mus musculus. 50 samples. Type: Expression profiling by high throughput sequencing.
A Fungal Effector Suppresses the Nuclear Export of AGO1-miRNA Complex to Promote Infection in Plants
GEO Series GSE190467. Arabidopsis thaliana. 12 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.