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115
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ShareScore release 0.9.0
Dataset results
115 results for “data deletion”
live cell super-resolution data_dual_color_cell_line_CTCF_E-2_deletion
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Raw data to: "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection"
<p>Raw data underlying the publication by Narr et al. entitled "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection".</p>
Data from: Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion
Hippocampal place cells represent the cellular substrate of episodic memory. Place cell ensembles reorganize to support learning but must also maintain stable representations to facilitate memory recall. Despite extensive research, the learning-related role of place cell dynamics in health and disease remains elusive. Using chronic two-photon Ca2+ imaging in hippocampal area CA1 of wild-type and Df(16)A+/− mice, an animal model of 22q11.2 deletion syndrome, one of the most common genetic risk factors for cognitive dysfunction and schizophrenia, we found that goal-oriented learning in wild-type mice was supported by stable spatial maps and robust remapping of place fields toward the goal location. Df(16)A+/− mice showed a significant learning deficit accompanied by reduced spatial map stability and the absence of goal-directed place cell reorganization. These results expand our understanding of the hippocampal ensemble dynamics supporting cognitive flexibility and demonstrate their importance in a model of 22q11.2-associated cognitive dysfunction.
Data from: Mining for single nucleotide polymorphisms and insertions / deletions in expressed sequence tag libraries of oil palm
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Data from: Upon accounting for the impact of isoenzyme loss, gene deletion costs anticorrelate with their evolutionary rates
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Data from: Recurrent gene deletions and the evolution of adaptive cyanogenesis polymorphisms in white clover (Trifolium repens L.)
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Data from: Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion
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Data from: Exploring the selective constraint on the sizes of insertions and deletions in 5’ untranslated regions in mammals
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Expression data from enteroid deleted for HDAC1 or HDAC2
GEO Series GSE124146. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Expression data from jejunum IEC deleted for both HDAC1 and HDAC2
GEO Series GSE158522. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
The transcriptome comparison data between Saccharomyces cerevisiae cells in thi2p deletion strains and the control strains BSGX001 in xylose consumption phase after glucose depleted in glucose-xylose
GEO Series GSE119333. Saccharomyces cerevisiae. 6 samples. Type: Expression profiling by high throughput sequencing.
Mechanism of tolerance improvement of Escherichia coli W against 3-hydroxypropionic acid by deletion of a less characterized transcription factor yieP (ChIP-exo data)
GEO Series GSE133708. Escherichia coli K-12. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
TSA Breast Cancer Wild-type or RIPK1 Deletion Tumors Single-Cell RNA Sequencing Data for CD45+ and CD45- Cell Types
GEO Series GSE196178. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Intranasal delivery of NS1-deleted influenza virus vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response (Mouse Lung RNA-seq Data)
GEO Series GSE227647. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
RNA-sequencing data for 923 enhancer deletion newborn mouse whole skin
GEO Series GSE158869. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA-seq data for control and epicardial-specific Prmt1-deletion hearts at E12.5
GEO Series GSE144271. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Expression and 5' end mapping data for Mycobacterium tuberculosis with deletion of Rv2752c/rnj
GEO Series GSE196357. Mycobacterium tuberculosis H37Rv. 12 samples. Type: Expression profiling by high throughput sequencing; Other.
Intranasal delivery of NS1-deleted influenza virus vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response (Hamster Lung RNA-seq Data)
GEO Series GSE228112. Mesocricetus auratus. 29 samples. Type: Expression profiling by high throughput sequencing.
Genomic profiles of mouse liver tissue harboring deletion of RB and/or p53, untreated or post-hepatocarcinogen treatment [CGH data]
GEO Series GSE29847. Mus musculus. 7 samples. Type: Genome variation profiling by genome tiling array.
Data from: Hepatocyte-specific deletion of TIPARP, a negative regulator of the aryl hydrocarbon receptor, is sufficient to increase sensitivity to dioxin-induced wasting syndrome
The aryl hydrocarbon receptor (AHR) mediates the toxic effects of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD), which include thymic atrophy, steatohepatitis, and a lethal wasting syndrome in laboratory rodents. Although the mechanisms of dioxin toxicity remain unknown, AHR signaling in hepatocytes is necessary for dioxin-induced liver toxicity. We previously reported that loss of TCDD-inducible poly(ADP-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities. To test the hypothesis that TIPARP is a negative regulator of AHR signaling in hepatocytes, we generated Tiparpfl/fl mice in which exon 3 of Tiparp is flanked by loxP sites, followed by Cre-lox technology to create hepatocyte-specific (Tiparpfl/flCreAlb) and whole-body (Tiparpfl/flCreCMV; TiparpEx3-/-) Tiparp null mice. Tiparpfl/flCreAlb and TiparpEx3-/- mice given a single injection of 10 g/kg dioxin did not survive beyond day 7 and 9, respectively, while all Tiparp+/+ mice survived the 30-day treatment. Dioxin-exposed Tiparpfl/flCreAlb and TiparpEx3-/- mice had increased steatohepatitis and hepatotoxicity as indicated by greater staining of neutral lipids and serum alanine aminotransferase activity than similarly treated wild-type mice. Tiparpfl/flCreAlb and TiparpEx3-/- mice exhibited augmented AHR signalling, denoted by increased dioxin-induced gene expression. Metabolomic studies revealed alterations in lipid and amino acid metabolism in liver extracts from Tiparpfl/flCreAlb mice compared with wild-type mice. Taken together, these data illustrate that TIPARP is an important negative regulator of AHR activity, and that its specific loss in hepatocytes is sufficient to increase sensitivity to dioxin-induced steatohepatitis and lethality.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.