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361 results for “derived response”
Data from: Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes
Cardiomyocytes from human induced pluripotent stem cells (hiPSC-CMs) are increasingly recognized as valuable for determining the effects of drugs on ion channels but they do not always accurately predict contractile responses of the human heart. This is in part attributable to their immaturity but the sensitivity of measurement tools may also be limiting. Measuring action potential, calcium flux or contraction individually misses critical information that is captured when interrogating the complete excitation-contraction coupling cascade simultaneously. Here, we develop an hypothesis-based statistical algorithm that identifies mechanisms of action. We design and build a high-speed optical system to measure action potential, cytosolic calcium and contraction simultaneously using fluorescent sensors. These measurements are automatically processed, quantified and then assessed by the algorithm. Multiplexing these three critical physical features of hiPSC-CMs allows identification of all major drug classes affecting contractility with detection sensitivities higher than individual measurement of action potential, cytosolic calcium or contraction.
Figure 8 from: Work T, St Onge B, Jacobs J (2011) Response of female beetles to LIDAR derived topographic variables in Eastern boreal mixedwood forests (Coleoptera, Carabidae). ZooKeys 147: 623-639. https://doi.org/10.3897/zookeys.147.2013
Figure 8 - Probability of collecting female Platynus decentis with changes in azimuth and slope when additional variables are held constant at their respective means. Both dashed and solid lines represent model parameters derived from full logistic model. Regression slopes for elevation appear near zero as total range of elevation is relatively small.
Figure 6 from: Work T, St Onge B, Jacobs J (2011) Response of female beetles to LIDAR derived topographic variables in Eastern boreal mixedwood forests (Coleoptera, Carabidae). ZooKeys 147: 623-639. https://doi.org/10.3897/zookeys.147.2013
Figure 6 - Probability of collecting female Pterostichus pensylvanicus with changes in azimuth and slope when additional variables are held constant at their respective means. Dashed lines represent model parameters derived from full logistic model. Solid lines represent model parameters of reduced logistic model including only curvature, FAC and intercept.
Figure 2 from: Work T, St Onge B, Jacobs J (2011) Response of female beetles to LIDAR derived topographic variables in Eastern boreal mixedwood forests (Coleoptera, Carabidae). ZooKeys 147: 623-639. https://doi.org/10.3897/zookeys.147.2013
Figure 2 - Probability of collecting female Calathus ingratus with changes in azimuth and slope when additional variables are held constant at their respective means. Dashed lines represent model parameters derived from full logistic model. Solid lines represent model parameters of reduced logistic model including only azimuth, slope and intercept.
Figure 7 from: Work T, St Onge B, Jacobs J (2011) Response of female beetles to LIDAR derived topographic variables in Eastern boreal mixedwood forests (Coleoptera, Carabidae). ZooKeys 147: 623-639. https://doi.org/10.3897/zookeys.147.2013
Figure 7 - Probability of collecting female Sphaeroderus nitidicollis with changes in azimuth and slope when additional variables are held constant at their respective means. Dashed lines represent model parameters derived from full logistic model. Solid lines represent model parameters of reduced logistic model including only curvature, FAC and intercept.
Figure 5 from: Work T, St Onge B, Jacobs J (2011) Response of female beetles to LIDAR derived topographic variables in Eastern boreal mixedwood forests (Coleoptera, Carabidae). ZooKeys 147: 623-639. https://doi.org/10.3897/zookeys.147.2013
Figure 5 - Figure 5. Probability of collecting female Synuchus impunctatus with changes in azimuth and slope when additional variables are held constant at their respective means. Dashed lines represent model parameters derived from full logistic model. Solid lines represent model parameters of reduced logistic model including only curvature, FAC and intercept.
Figure 4 from: Work T, St Onge B, Jacobs J (2011) Response of female beetles to LIDAR derived topographic variables in Eastern boreal mixedwood forests (Coleoptera, Carabidae). ZooKeys 147: 623-639. https://doi.org/10.3897/zookeys.147.2013
Figure 4 - Probability of collecting female Pterostichus coracinus with changes in azimuth, slope and elevation when additional variables are held constant at their respective means. Dashed lines represent model parameters derived from full logistic model. Solid lines represent model parameters of reduced logistic model including only azimuth, slope, elevation and intercept. Regression slopes for elevation appear near zero as total range of elevation is relatively small.
Figure 1 from: Work T, St Onge B, Jacobs J (2011) Response of female beetles to LIDAR derived topographic variables in Eastern boreal mixedwood forests (Coleoptera, Carabidae). ZooKeys 147: 623-639. https://doi.org/10.3897/zookeys.147.2013
Figure 1 - Probability of collecting female Agonum retractum with changes in azimuth and slope when additional variables are held constant at their respective means. Dashed lines represent model parameters derived from full logistic model. Solid lines represent model parameters of reduced logistic model including only azimuth, slope and intercept.
Figure 3 from: Work T, St Onge B, Jacobs J (2011) Response of female beetles to LIDAR derived topographic variables in Eastern boreal mixedwood forests (Coleoptera, Carabidae). ZooKeys 147: 623-639. https://doi.org/10.3897/zookeys.147.2013
Figure 3 - Probability of collecting female Pterostichus adstrictus with changes in azimuth, slope and elevation when additional variables are held constant at their respective means. Dashed lines represent model parameters derived from full logistic model. Solid lines represent model parameters of reduced logistic model including only azimuth, slope, elevation and intercept. Regression slopes for elevation appear near zero as total range of elevation is relatively small.
A Study to Investigate Efficacy of Two Experimental Oral Rinses in Providing Long Term Relief From Pain Derived From Exposed Dentine in Response to Chemical, Thermal, Tactile, or Osmotic Stimuli.
ClinicalTrials.gov study NCT02651467. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes
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Data from: The extracellular domains of IgG1 and T cell-derived IL-4/IL-13 are critical for the polyclonal memory IgE response in vivo
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Derivation of the functional response of a foraging herbivore
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A NAFLD Model Created By Endoplasmic Reticulum Stress Response-Associated Steatosis in Human Induced Pluripotent Stem Cell-Derived Hepatocytes
GEO Series GSE116185. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Bone-marrow derived macrophages response to the Whipple's disease agent, Tropheryma whipplei
GEO Series GSE16180. Mus musculus. 6 samples. Type: Expression profiling by array.
Pathway Signatures Derived from On-treatment Tumor Specimens Predict Response to Anti-PD1 Blockade in Metastatic Melanoma
GEO Series GSE168204. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
A p53 score derived from TP53 CRISPR/Cas9 HMCLs predicts survival and reveals major role of BAX in BH3 mimetics response
GEO Series GSE245163. Homo sapiens. 138 samples. Type: Expression profiling by high throughput sequencing.
Guadecitabine increases response to combined anti-CTLA-4 and anti-PD-1 treatment in mouse melanoma in vivo by controlling the responses of T-cells, myeloid derived suppressor cells and NK cells
GEO Series GSE220698. Mus musculus. 24 samples. Type: Methylation profiling by array.
Transcription profile analysis of wild type bone marrow derived-macrophages in response to Anisomycin, type I and type II interferons and the combination of them
GEO Series GSE199128. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
The atypical KRASQ22K mutation directs TGF-β response towards partial epithelial-to-mesenchymal transition in patient-derived colorectal cancer tumoroids
GEO Series GSE270815. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.