Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
86
datasets available to search
ShareScore release 0.9.0
Dataset results
86 results for “dioxins”
Comparison of hepatic NRF2 and AHR binding in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated mice demonstrates NRF2-independent PKM2 induction
GEO Series GSE109866. Mus musculus. 45 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Cross-Species Comparisons of Transcriptomic Alterations in Human and Rat Primary Hepatocytes Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin: rat samples
GEO Series GSE34250. Rattus norvegicus. 60 samples. Type: Expression profiling by array.
Dioxin-elicited decrease in cobalamin redirects hepatic propionyl-CoA metabolism to the β–oxidation-like pathway resulting in acrylyl-CoA conjugate accumulation
GEO Series GSE203302. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Dioxin lethality: aryl hydrocarbon receptor (AHR)-mediated gene expression in a rat resistant model
GEO Series GSE10083. Rattus norvegicus. 40 samples. Type: Expression profiling by array.
Dioxin and AHR impairs mesoderm gene expression and cardiac differentiation in human embryonic stem cells
GEO Series GSE122003. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Temporal comparison of transcriptomic alterations in human, mouse and rat primary B lymphocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
GEO Series GSE80953. Mus musculus; Rattus norvegicus; Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Time-Course Analysis of Hepatic Single-Nuclei RNA-Sequencing in Mice Treated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
GEO Series GSE254121. Mus musculus. 42 samples. Type: Expression profiling by high throughput sequencing.
Transgenerational Disease Specific Epigenetic Sperm Biomarkers after Ancestral Exposure to Dioxin
GEO Series GSE157539. Rattus norvegicus. 52 samples. Type: Methylation profiling by high throughput sequencing.
Mining gene expression data for low doses of radiation and pollutants (dioxin, toluene, formaldehyde)
GEO Series GSE50377. Drosophila melanogaster. 10 samples. Type: Expression profiling by high throughput sequencing.
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) have increased sensitivity to TCDD-induced hepatotoxicity and lethali
GEO Series GSE167205. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Application of singe nuclei RNA sequencing to assess the hepatic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin
GEO Series GSE148339. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
2,3,7,8-tetrachlorodibenzo-p-dioxin modifies alternative splicing in mouse liver
GEO Series GSE126328. Mus musculus. 12 samples. Type: Expression profiling by array.
Effect of maternal exposure to dioxin on the pituitary and hypothalamic expression of genes in PND70 male pups
GEO Series GSE48100. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
RNA-sequencing of 14 diverse mouse strains treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
GEO Series GSE167328. Mus musculus. 84 samples. Type: Expression profiling by high throughput sequencing.
Using fish models to understand the role of aryl hydrocarbon receptor (AHR)-interacting protein (AIP) in controlling sensitivity and resistance to dioxin-like compounds in vivo 5dpf
GEO Series GSE295203. Danio rerio. 24 samples. Type: Expression profiling by high throughput sequencing.
Dioxin-like compound exposures and DNA methylation in the Anniston Community Health Survey Phase II
GEO Series GSE149412. Homo sapiens. 292 samples. Type: Methylation profiling by genome tiling array.
Data from: Hepatocyte-specific deletion of TIPARP, a negative regulator of the aryl hydrocarbon receptor, is sufficient to increase sensitivity to dioxin-induced wasting syndrome
The aryl hydrocarbon receptor (AHR) mediates the toxic effects of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD), which include thymic atrophy, steatohepatitis, and a lethal wasting syndrome in laboratory rodents. Although the mechanisms of dioxin toxicity remain unknown, AHR signaling in hepatocytes is necessary for dioxin-induced liver toxicity. We previously reported that loss of TCDD-inducible poly(ADP-ribose) polymerase (TIPARP/PARP7/ARTD14), an AHR target gene and mono-ADP-ribosyltransferase, increases the sensitivity of mice to dioxin-induced toxicities. To test the hypothesis that TIPARP is a negative regulator of AHR signaling in hepatocytes, we generated Tiparpfl/fl mice in which exon 3 of Tiparp is flanked by loxP sites, followed by Cre-lox technology to create hepatocyte-specific (Tiparpfl/flCreAlb) and whole-body (Tiparpfl/flCreCMV; TiparpEx3-/-) Tiparp null mice. Tiparpfl/flCreAlb and TiparpEx3-/- mice given a single injection of 10 g/kg dioxin did not survive beyond day 7 and 9, respectively, while all Tiparp+/+ mice survived the 30-day treatment. Dioxin-exposed Tiparpfl/flCreAlb and TiparpEx3-/- mice had increased steatohepatitis and hepatotoxicity as indicated by greater staining of neutral lipids and serum alanine aminotransferase activity than similarly treated wild-type mice. Tiparpfl/flCreAlb and TiparpEx3-/- mice exhibited augmented AHR signalling, denoted by increased dioxin-induced gene expression. Metabolomic studies revealed alterations in lipid and amino acid metabolism in liver extracts from Tiparpfl/flCreAlb mice compared with wild-type mice. Taken together, these data illustrate that TIPARP is an important negative regulator of AHR activity, and that its specific loss in hepatocytes is sufficient to increase sensitivity to dioxin-induced steatohepatitis and lethality.
Transcriptional Profiles Induced by the Aryl Hydrocarbon Receptor Agonists 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-Tetrachlorodibenzofuran and 2,3,4,7,8-Pentachlorodibenzofuran in Primary Rat Hep
GEO Series GSE29095. Rattus norvegicus. 28 samples. Type: Expression profiling by array.
Dioxin (TCDD) Induces Epigenetic Transgenerational Inheritance of Adult Onset Disease and Sperm Epimutations
GEO Series GSE59552. Rattus norvegicus. 3 samples. Type: Methylation profiling by genome tiling array.
Data from: Hepatocyte-specific deletion of TIPARP, a negative regulator of the aryl hydrocarbon receptor, is sufficient to increase sensitivity to dioxin-induced wasting syndrome
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.