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1,037 results for “disease severity.”
The effect of parasite dose on disease severity in the rodent malaria Plasmodium chabaudi
<p>Experiments were designed to look at the relationship between infective dose and disease severity using two clones of <em>Plasmodium chabaudi</em> that differ in virulence. We asked whether there were dose–severity relationships, whether clone differences in virulence were maintained over a range of doses, and whether disease severity could be accounted for by parasite dynamics. Groups of mice were infected with parasite doses differing by an order of magnitude, ranging from 100 to 1×10<sup><sup>8</sup></sup> parasites. Infective dose affected the probability of death, but only with the more virulent clone. Dose also affected morbidity. For both clones, higher doses induced greater anaemia. Larger doses caused greater weight loss, but only for infections with the more virulent clone. Here, for a given dose, mice lost a fixed amount of weight, irrespective of their initial weight. Larger doses induced earlier mortality and morbidity than did lower dose treatments. Finally, dose affected parasite dynamics, with earlier and higher peak parasite densities in larger dose infections. All these effects were small relative to clone differences in disease severity, which were apparent across the range of doses. Dose effects were manifested through the timing and/or magnitude of peak parasite densities, broadly supporting the idea that dose affects disease severity by altering the time the host has to control parasite densities and ameliorate the effects of parasites. We discuss the possible efficacy of intervention strategies aimed at reducing human disease severity by reducing infective parasite dose.</p>
Longitudinal proteomic profiling of high-risk patients with COVID-19 reveals markers of severity and predictors of fatal disease
<p>End-stage kidney disease (ESKD) patients are at high risk of severe COVID-19. We performed dense serial blood sampling in hospitalised and non-hospitalised ESKD patients with COVID-19 (n=256 samples from 55 patients) and used Olink immunoassays to measure 436 circulating proteins. Comparison to 51 non-infected ESKD patients revealed 221 proteins differentially expressed in COVID-19, of which 69.7% replicated in an independent cohort of 46 COVID-19 patients. 203 proteins were associated with clinical severity scores, including IL6, markers of monocyte recruitment (e.g. CCL2, CCL7), neutrophil activation (e.g proteinase-3) and epithelial injury (e.g. KRT19). Random Forests machine learning identified predictors of current or future severity such as KRT19, PARP1, PADI2, CCL7, and IL1RL1 (ST2). Survival analysis with joint models revealed 69 predictors of death including IL22RA1, CCL28, and the neutrophil-derived chemotaxin AZU1 (Azurocidin). Finally, longitudinal modelling with linear mixed models uncovered 32 proteins that display different temporal profiles in severe versus non-severe disease, including integrins and adhesion molecules. Our findings point to aberrant innate immune activation and leucocyte-endothelial interactions as central to the pathology of severe COVID-19. The data from this unique cohort of high-risk individuals provide a valuable resource for identifying drug targets in COVID-19.</p>
Voxel-wise maps for the paper: Longitudinal associations of magnetic susceptibility with clinical severity in Parkinson's disease
<p>This upload contains voxel-wise group level QSM data, and statistical maps for group level results associated with the paper: Longitudinal associations of magnetic susceptibility with clinical severity in Parkinson's disease.</p> <p>The assocaited code for reproducing these statistical maps can be found here: <a href="https://github.com/gecthomas/QSM_PD_longitudinal">gecthomas/QSM_PD_longitudinal (github.com)</a></p>
Fig. 3 in Hamatospiculum flagellispiculosum (Nematoda: Diplotriaenidae) causing severe disease in a new host from Argentine Patagonia: Campephilus magellanicus (Aves: Picidae)
Fig. 3. Schematic outline of the tail of male Hamatospiculum flagellispiculosum.
Data from: Signature of altered retinal microstructures and electrophysiology in schizophrenia spectrum disorders is associated with disease severity and polygenic risk
<p>This dataset contains supporting data for the publication: </p> <p>Boudriot, E.<em> et al.</em> Signature of altered retinal microstructures and electrophysiology in schizophrenia spectrum disorders is associated with disease severity and polygenic risk. <em>Biological Psychiatry</em><span> </span><a href="https://doi.org/10.1016/j.biopsych.2024.04.014">https://doi.org/10.1016/j.biopsych.2024.04.014</a></p> <p> </p> <p>Files:</p> <ul> <li><em>clinical.csv </em>contains data from clinical assessment and polygenic risk scores for schizophrenia</li> <li><em>ophthalmic_examination.csv </em>contains data on spherical equivalent, intraocular pressure and visual acuity</li> <li><em>oct.csv </em>contains segmentation output from Iowa Reference Algorithms</li> <li><em>erg.csv </em>contains pre-processed ERG data for the four ERG conditions</li> <li><em>mri.csv </em>contains ICV-corrected MRI volumes</li> </ul>
Data from a field plot experiment with the canola pathogen Leptosphaeria maculans including disease severity at the leaf spot and canker stages of the epidemic, and population composition as isolates infectivity pathotypes.
<p><strong>Data set</strong></p> <p>Data are from an experiment simulating how differences in <em>Brassica napus</em> resistance deployment strategies and landscape connectivity influence epidemic severity and pathogen population composition of the fungus <em>Leptosphaeria maculans</em> on field plots inoculated with combinations of stubble in 2016 at CSIRO Canberra, ACT, Australia. Disease severity was assessed on the 60 field plots [Data_severity.csv] and 1490 isolates were sampled and assessed for infectivity [Data_infectivity.csv]. This dataset is described and analyzed in Bousset et al. (2018).</p> <p>Treatments were factorial combination of Resistance, Genetic Connectivity and Spatial Connectivity, replicated in 4 blocks (B1 to B4). Resistance has 3 categories (Rlm4, Rlm6 LepR1) differing by the resistance genes in oilseed rape varieties. Genetic Connectivity has 2 levels (HighGC, LowGC) differing by the pre-adaptation of the stubble populations to the host variety. Spatial Connectivity has two levels (HighSC, LowSC) differing by the stubble load. Control plots had NoStubble.</p> <p><strong>Data files</strong></p> <p>[Data_severity.csv] Disease severity was assessed on the 60 field plots at leaf spot and canker stages of the epidemic. Leaf spots data are counts. Canker data are numbers of stems in 12 categories defined by the cankered area on cross section (0 = no canker to 100 = fully cankered).</p> <p>[Data_infectivity.csv] Two types of isolates (122 from 3 stubble sources with contrasting preadaptation and 1368 from leaves sampled on 50 field plots) were tested for infectivity response (V = infective; A = non-infective) on the three host varieties (Rlm4, Rlm6 LepR1), at the seedling stage in greenhouse.</p> <p><strong>Associated publication</strong></p> <p>Bousset L, Sprague S, Thrall PH, Barrett LG (2018). Spatio-temporal connectivity and host resistance influence evolutionary and epidemiological dynamics of the canola pathogen <em>Leptosphaeria maculans. Evolutionary Applications</em> [ DOI: 10.1111/eva.12630 ].</p> <p><strong>Funding information</strong></p> <p>This work benefited from the financial support of INRA – the French National Institute for Agronomical Research, a CSIRO Sir Frederick McMaster fellowship to L. Bousset (Impact of inoculum carry-over on landscape dynamics of the blackleg canola pathogen) and the Grains Research & Development Corporation (GRDC Grant CSP00192)</p>
Illness perception mediates the relationship between the severity of symptoms and perceived health status in patients with Behcet's disease.
<p><strong>Abstract</strong></p> <p><em>Objective</em>. To investigate the relationship between psychological representations of illness, perceived health status and self-assessment of symptom severity in patients with <strong>Behçet's</strong>Disease – a rare long-term incurable condition with unclear etiology.</p> <p><em>Methods</em>. Using cross-sectional survey design, data on self-administered questionnaires on illness perception, health status, symptoms severity and demographic characteristics were collected from 273 patients with <strong>Behçet's</strong>Disease (age range 18 – 65+). The data were subjected to mediation analysis to test whether cognitive and emotional components of illness perception mediate the relationship between the severity of symptoms and heath status.</p> <p><em>Results</em>. The results support our hypotheses that cognitive components of illness perception (perceived consequences and identity of the illness) mediate the link between symptom activity and pain, whereas emotional components of the illness (emotional representations about the illness) mediate the relationship between disease activity and perceived energy level.</p> <p> <em>Conclusion</em>. The robustness of these mediation effects suggests potential directions for clinical psychologists and health care practitioners in developing support programmes. We supplement our study with Open Access database containing information about type of medication, comorbid mood disorder, detailed measurement of the severity of BD symptomsfor sharing and accumulating multidisciplinary knowledge aiming to support the development of interventions. Addressing psychological aspects ofBD will help to manage complex patients effectively.</p> <p>Database of survey (complete)</p>
The conflict between hosts and non-hosts changes the severity of diseases in degraded grassland plant communities
<p>load: disease severity of plant community</p> <p>richnes: species richness</p> <p>Nonhost: Non-hosts richness</p> <p>coverage: relative coverage</p> <p>RHost: relative hosts richness</p> <p>PD: Faith's phylogenetic distance</p> <p>beta: beta diversity of plant community</p> <p>SLA: CWM SLA</p> <p>LN: CWM leaf N content</p> <p>LP:CWM leaf P content</p> <p>NP: CWM leaf N:P</p> <p>group: degree of grassland degradation</p> <p>Shannon: Shannon index of plant community</p> <p>Simpson: Simpsion index of plant community</p> <p>Pielou: Pielou index of plant community</p> <p>marglef: Marglef index of plant community</p>
SARS-CoV-2 viral loads across the upper and lower respiratory tract, sex, disease severity and age groups for adult and pediatric COVID-19
<p>This dataset shows SARS-CoV-2 respiratory viral loads (viral RNA concentration in the respiratory tract) in the upper and lower respiratory tract for age, sex and COVID-19 severity groups. The data were obtained from a systematic review. The model outputs show the Weibull distributions, case percentiles, and sensitivity & specificity when using SARS-CoV-2 viral load (URT or LRT) as a prognostic indicator. See our paper for more information.</p>
Safety and Efficacy Study of JNJ-64304500 in Participants With Moderately to Severely Active Crohn's Disease
ClinicalTrials.gov study NCT02877134. IPD Sharing: Not stated. Countries: 14. Publications: 2.
Repeat Dose Study of GSK3772847 in Participants With Moderate to Severe Asthma With Allergic Fungal Airway Disease (AFAD)
ClinicalTrials.gov study NCT03393806. IPD Sharing: YES. Countries: 4. Publications: 1.
3-year Study in Dry Eye Disease Patients With Severe Keratitis Receiving Ikervis® (1mg/mL Ciclosporin)
ClinicalTrials.gov study NCT04144413. IPD Sharing: Not stated. Countries: 7. Publications: 0.
A Study to Evaluate the Efficacy and Safety of Sirukumab in Confirmed Severe or Critical Confirmed Coronavirus Disease (COVID)-19
ClinicalTrials.gov study NCT04380961. IPD Sharing: YES. Countries: 1. Publications: 1.
Efficacy and Safety of Aclidinium Bromide for Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (LAS-MD-33)
ClinicalTrials.gov study NCT00891462. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Efficacy and Safety of Memantine in Moderate to Severe Alzheimer's Disease
ClinicalTrials.gov study NCT00857649. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Abrilumab (AMG 181) in Adults With Moderate to Severe Crohn's Disease
ClinicalTrials.gov study NCT01696396. IPD Sharing: Not stated. Countries: 12. Publications: 1.
A Phase 2a Safety and Efficacy Open-Label Study of PRA023 in Subjects With Moderately to Severely Active Crohn's Disease
ClinicalTrials.gov study NCT05013905. IPD Sharing: YES. Countries: 8. Publications: 1.
Rabeprazole Extended-Release 50 mg Versus Esomeprazole 40 mg for Healing and Symptomatic Relief of Moderate to Severe Erosive Gastroesophageal Reflux Disease (GERD)
ClinicalTrials.gov study NCT00658528. IPD Sharing: Not stated. Countries: 13. Publications: 1.
Effects of a Supervised Rehabilitation Program on Disease Severity in Spastic Ataxias
ClinicalTrials.gov study NCT06261424. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Assess the Safety, Tolerability, and Immunogenicity of RSVpreF in Adults at High Risk of Severe RSV Disease
ClinicalTrials.gov study NCT05842967. IPD Sharing: YES. Countries: 1. Publications: 2.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.