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Fig. 4 in Hamatospiculum flagellispiculosum (Nematoda: Diplotriaenidae) causing severe disease in a new host from Argentine Patagonia: Campephilus magellanicus (Aves: Picidae)

Fig. 4. Optical microscope micrograph of histopathological assessment of muscular tissues dissected from articulations affected by a parasitic infection in Campephilus magellanicus: (A) Sample from the right knee exhibiting loss of the skeletal muscle architecture and nematode eggs (dark dots at lower half), contiguous to muscle fibers with normal tissue architecture (upper half), Bar = 200 μm. (B) Sample from the left tibiotarsus mass showing myofibers of variable shape and size, diffuse mononuclear infiltration, and several eggs, Bar = 100 μm. (C) Two thin-shelled eggs with fully differentiated L1 at the centre of the image, surrounded by mononuclear cells, Bar = 20 μm.

Fig. 2 in Hamatospiculum flagellispiculosum (Nematoda: Diplotriaenidae) causing severe disease in a new host from Argentine Patagonia: Campephilus magellanicus (Aves: Picidae)

Fig. 2. Scanning electron micrograph (SEM) of female Hamatospiculum flagellispiculosum: (A) Detail of epaulette in anterior end (frontal view): a: amphid, b: cephalic papilla in inner circle, c: cephalic papilla in outer circle, d: tooth. (B) Anterior end with vulva (ventral view), Bar = 100 μm. (C) Anterior end (lateral view), Bar = 20 μm. (D) Detail of anal region (caudal view) with atrophied anus, Bar = 200 μm.

Fig. 1 in Hamatospiculum flagellispiculosum (Nematoda: Diplotriaenidae) causing severe disease in a new host from Argentine Patagonia: Campephilus magellanicus (Aves: Picidae)

Fig. 1. Parasitic infections at joints of a necropsied Magellanic woodpecker (Campephilus magellanicus) adult female from Argentine Patagonia: (A) Dissected distocranial extremity of the left tibiotarsus. (B) Urogygial gland area increased in size. Arrows show roundworms present in the tissues extracted from the affected locations.

Fig. 5 in Hamatospiculum flagellispiculosum (Nematoda: Diplotriaenidae) causing severe disease in a new host from Argentine Patagonia: Campephilus magellanicus (Aves: Picidae)

Fig. 5. Hamatospiculum flagellispiculosum, optical microscope micrograph of eggs: (A) Egg with first-stage larvae (L1), Bar = 15 μm. (B) Larvae hatching, Bar = 15 μm.

opencc-by-4.0Dec 2013View details →

Figure 3 in Severe glomerular disease in juvenile grey snapper Lutjanus griseus L. in the Gulf of Mexico caused by the myxozoan Sphaerospora motemarini n. sp.

Figure 3. SSU rDNA-based maximum likelihood (GTR + Γ model) tree of 26 myxosporean sequences showing the phylogenetic position of Sphaerospora motemarini n. sp. amongst all other polysporoplasmid Sphaerospora spp. sequenced to date (red) and within the Sphaerospora sensu stricto clade (yellow). Members of marine (blue) and freshwater (green) myxosporean lineages were used as outgroups. Maximum likelihood bootstraps/maximum parsimony bootstraps/Bayesian posterior probabilities shown at nodes. Dashes indicate bootstrap values <50 or not present in the maximum parsimony or Bayesian tree.

opencc-by-4.0Dec 2013View details →

Figure 2 in Severe glomerular disease in juvenile grey snapper Lutjanus griseus L. in the Gulf of Mexico caused by the myxozoan Sphaerospora motemarini n. sp.

Figure 2. Line drawing of spore of Sphaerospora motemarini n. sp. summarizing all morphological details in two dimensions; spore with bilateral symmetry, labels given only on one side: SV = spore valve, VN = nucleus of valve cell, OP = ornamental surface pits on posterior part of spore valve, PC = polar capsule containing coiled polar filament (PF), PN = nucleus of polar capsule, SP = uninucleated sporoplasms (6); bar = 5 µm.

opencc-by-4.0Dec 2013View details →

Figure 1 in Severe glomerular disease in juvenile grey snapper Lutjanus griseus L. in the Gulf of Mexico caused by the myxozoan Sphaerospora motemarini n. sp.

Figure 1. Morphology and histopathology of Sphaerospora motemarini n. sp. in grey snapper, Lutjanus griseus. (A) Mature spore in fresh kidney smear showing thickened suture at apical part (transparent arrowhead), two prominent bulges at posterior part (black arrowheads) and valve surface ornamentation (detailed in D) at the posteriolateral part of the spore; bar = 10 µm. (B) DAPI nuclear staining showing polysporoplasmic nature of spore (4 out of 6 sporoplasms visible in plane of image); bar = 10 µm. (C) Pseudoplasmodium containing two croissant-shaped sporoplasms (only visible around left spore) and two spores; bar = 10 µm. (D) SEM showing spore surface ornamentation in the shape of pits providing an opening to a multilayered canal system; bar = 5 µm. (E) Fresh smear of kidney showing early plasmodial stages (arrowheads) in a glomerulus; bar = 20 µm. (F–H) Histological sections stained with H&E; bar = 50 µm (F). Histopathological changes showing massive enlargement of renal corpuscles, with arrows in small insert (bottom left) indicating uninfected corpuscles of normal size in an uninfected kidney; bar = 50 µm. (G) Thickening of Bowman's capsule (arrows) and proliferation of mesangial cells; bar = 50 µm. (H) Engulfment of a spore by a melanin-rich macrophage (brown color); bar = 10 µm.

opencc-by-4.0Aug 2017View details →

Fig. 1 in Apparent effect of chronic Plasmodium infections on disease severity caused by experimental infections with Mycoplasma gallisepticum in house finches

Fig. 1. Mean severity of eye lesions ± SE (circles), and M. gallisepticum-load (log (qPCR+1)) (triangles) of birds infected through horizontal transmission with the CA2015 strain of M. gallisepticum. Birds in which Plasmodium was detected by PCR (grey symbols) developed more severe disease than birds in which Plasmodium was not found (white symbol). As there is no significant interaction between M. gallisepticum ‾strain and Plasmodium infection (Table 2) the results for the other M. gallisepticum strains are qualitatively similar and therefore not shown.

opencc-by-4.0Feb 2023View details →

Spatial transcriptomics stratifies health and psoriatic disease severity by emergent cellular ecosystems

While human inflammatory skin diseases' cellular and molecular features are well-characterized, their tissue context and systemic impact remain poorly understood. We thus profiled human psoriasis (PsO) as a prototypic immune-mediated condition with a high preference for extra-cutaneous involvement. Spatial transcriptomics (ST) analyses of 25 healthy, active, and clinically uninvolved skin biopsies, and integration with public single-cell transcriptomics data revealed striking differences in immune microniches between healthy and inflamed skin. Tissue scale-cartography further identified core disease features across all active lesions, including the emergence of an inflamed suprabasal epidermal state and the presence of B lymphocytes in lesional skin. Notably, both lesional and distal non-lesional samples were stratified by skin disease severity, and not by the presence of systemic disease. This segregation was driven by macrophage-, fibroblast- and lymphatic-enriched spatial regions with gene signatures associated with metabolic dysfunction. Taken together, these findings suggest that mild and severe forms of PsO have distinct molecular features and that severe PsO may profoundly alter the cellular and metabolic make up of distal unaffected skin sites. Additionally, our study provides an unprecedented resource for the research community to study spatial gene organization of healthy and inflamed human skin.

opencc-by-2.0Feb 2023View details →

Datasets for article Effect of disease prevalence and growth stage on symptoms severity in the Turnip mosaic virus - Arabidopsis thaliana pathosystem

Plants generate volatile organic compounds (VOCs) in response to biotic and abiotic stimuli that provide information about the physiological status of emitters to other individuals in the community.  Nearby receivers adjust their own defenses in response to these chemical cues.  The majority of studies to date has concentrated on the communication of abiotic stressors (e.g. salinity or drought) or herbivory.  Less attention had received the role of VOCs during microbial infections and almost nothing has been done for viruses.  Here we investigated the function of VOCs during turnip mosaic virus infection of Arabidopsis thaliana.  First, we looked at the influence of two factors on the kinetics of symptoms progression in receivers, namely the prevalence of infection in the population and the growth stage of the receiver plants at inoculation.  We found that young plants were more sensitive to the protective effect of VOCs than older ones, and that high infection prevalence results in a slower disease progression in receivers.  Second, we looked into the possibility that jasmonates could be VOC candidates.  To do this, we examined the kinetics of symptoms progression in jasmonate-insensitive and wild-type plants, and the results showed that the protective effect vanished in the mutant plants.  Third, we investigated the possibility that root communication would be also relevant.  Our findings showed that the kinetics of symptom progression across receivers was further slowed down when plants were housed in the same pot.  Together, our preliminary findings point to a potential function for disease prevalence in plant communities in regulating the severity of symptoms, this effect being mediated by VOCs.

A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Biologic Therapy

ClinicalTrials.gov study NCT03345836. IPD Sharing: YES. Countries: 48. Publications: 7.

Efficacy and Safety Study of Ontamalimab as Maintenance Treatment in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 307)

ClinicalTrials.gov study NCT03627091. IPD Sharing: YES. Countries: 34. Publications: 1.

Activity, Safety and Pharmacokinetics in Pediatric Subjects With Moderate and Severe Chronic Graft vs. Host Disease After Allogeneic Stem Cell Transplant

ClinicalTrials.gov study NCT03774082. IPD Sharing: YES. Countries: 14. Publications: 1.

A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment

ClinicalTrials.gov study NCT03104413. IPD Sharing: YES. Countries: 43. Publications: 5.

A Study Evaluating the Safety and Efficacy of Lovo-cel in Severe Sickle Cell Disease

ClinicalTrials.gov study NCT02140554. IPD Sharing: YES. Countries: 1. Publications: 5.

A Study of the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease

ClinicalTrials.gov study NCT03105128. IPD Sharing: YES. Countries: 44. Publications: 7.

Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of SAR440340 (Anti-IL-33 mAb) in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)

ClinicalTrials.gov study NCT03546907. IPD Sharing: YES. Countries: 10. Publications: 1.