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88 results for “dynamic targets”
FIG. 1 in Breeding Population Dynamics of Threatened Crawfish Frogs Inform Targets for Habitat Management
FIG. 1. (A) Post-birth, females-only, stage matrix model of Crawfish Frogs that accommodates age and state-specific transition probabilities and the ''temporary emigration'' of individuals that skip breeding or breed at other sites. (B) Projection matrix of the model used to estimate elasticities and sensitivities of vital rates. Parameters in the matrix model: embryonic survival (Se), tadpole survival (St), metamorph and juvenile survival (Sj), adult survival following the first breeding event (Sa1), adult survival following two or more breeding events (Sa2), probability that a one-year-old juvenile matures at age 2 (p), probability that a two-year-old juvenile matures at age 3 (q), the probability that a mature individual emigrates to become a non-breeding individual (c22), probability that a non-breeding individual remains a non-breeding individual (c'), and clutch size multiplied by 0.5 to represent half of all eggs developing into females (C). We assumed that all individuals mature by age 4. Individuals that emigrate to become a nonbreeding individual may either skip reproduction or breed at another site.
Dynamic interplay between target search and recognition for a Type I CRISPR-Cas system
<p>CRISPR-Cas effector complexes enable the defense against foreign nucleic acids and have recently been exploited as molecular tools for precise genome editing at a target locus. To bind and cleave their target, the CRISPR-Cas effectors have to interrogate the entire genome for the presence of a matching sequence. Here we dissect the target search and recognition process of the Type I CRISPR-Cas complex Cascade by simultaneously monitoring DNA binding and R-loop formation by the complex. We directly quantify the effect of DNA supercoiling on the target recognition probability and demonstrate that Cascade uses facilitated diffusion for its target search. We show that target search and target recognition are tightly linked and that DNA supercoiling and limited 1D diffusion need to be considered when understanding target recognition and target search by CRISPR-Cas enzymes and engineering more efficient and precise variants. </p>
Experimental files for Dynamics of plasmas produced by a laser pulse, inside a dense gaseous target, formed in an ambient gas
<p>Time development of plasmas produced by interaction of laser pulses, with a nitrogen gas, was investigated. The interaction took place inside a small portion of dense nitrogen gas injected temporarily into a chamber filled with the gas under low pressure. High-temperature plasmas produced directly by the laser pulse were a source of soft x rays and charged particles, ionizing and exciting the surrounding gas. In this way, low-temperature plasmas were produced. The formation of high-temperature plasmas was studied using soft x-ray spectroscopy and x-ray streak imaging. Low-temperature plasmas formed at various distances from the laser focus were investigated using an optical streak camera. The experimental data.zip file contains the experimental data from an X-ray spectrograph, X-ray streak camera and optical streak camera.</p> <p>Work supported by the National Science Centre, Poland, Grant Agreement No. UMO-2020/39/B/ST2/00509</p>
The Study of Microglia/Macrophages Involved Dynamic Evolution of Glioma Microenvironment and the Function and Visualization of Targeted Molecules of Glioma
ClinicalTrials.gov study NCT04781764. IPD Sharing: NO. Countries: 1. Publications: 9.
Dynamic Magnesium Replacement Strategies and 28-Day Mortality in Non-Cardiac Critically Ill Patients With Hypomagnesemia: A Target Trial Emulation
ClinicalTrials.gov study NCT07380542. IPD Sharing: NO. Countries: 1. Publications: 2.
Trade-offs between biodiversity and agriculture are moving targets in dynamic landscapes
Open the record for dataset details and reuse information.
Data from: Molecular docking and dynamics studies to identify novel active compounds targeting potential breast cancer receptor proteins from an indigenous herb Euphorbia thymifolia Linn
Open the record for dataset details and reuse information.
Data from: The organization and evolution of the Responder satellite in species of the Drosophila melanogaster group: dynamic evolution of a target of meiotic drive
Background: Satellite DNA can make up a substantial fraction of eukaryotic genomes and has roles in genome structure and chromosome segregation. The rapid evolution of satellite DNA can contribute to genomic instability and genetic incompatibilities between species. Despite its ubiquity and its contribution to genome evolution, we currently know little about the dynamics of satellite DNA evolution. The Responder (Rsp) satellite DNA family is found in the pericentric heterochromatin of chromosome 2 of Drosophila melanogaster. Rsp is well-known for being the target of Segregation Distorter (SD) an autosomal meiotic drive system in D. melanogaster. I present an evolutionary genetic analysis of the Rsp family of repeats in D. melanogaster and its closely-related species in the melanogaster group (D. simulans, D. sechellia, D. mauritiana, D. erecta, and D. yakuba) using a combination of available BAC sequences, whole genome shotgun Sanger reads, Illumina short read deep sequencing, and fluorescence in situ hybridization. Results: I show that Rsp repeats have euchromatic locations throughout the D. melanogaster genome, that Rsp arrays show evidence for concerted evolution, and that Rsp repeats exist outside of D. melanogaster, in the melanogaster group. The repeats in these species are considerably diverged at the sequence level compared to D. melanogaster, and have a strikingly different genomic distribution, even between closely-related sister taxa. Conclusions: The genomic organization of the Rsp repeat in the D. melanogaster genome is complex--it exists of large blocks of tandem repeats in the heterochromatin and small blocks of tandem repeats in the euchromatin. My discovery of heterochromatic Rsp-like sequences outside of D. melanogaster suggests that SD evolved after its target satellite and that the evolution of the Rsp satellite family is highly dynamic over a short evolutionary time scale (<240,000 years).
In silico molecular docking and molecular dynamic simulation of agarwood compounds with molecular targets of Alzheimer's disease
<p>We added Supplementary Figure 8a.</p>
Data from: The organization and evolution of the Responder satellite in species of the Drosophila melanogaster group: dynamic evolution of a target of meiotic drive
Open the record for dataset details and reuse information.
Dynamic chromatin targeting of BRD4 stimulates cardiac fibroblast activation [RNA-seq]
GEO Series GSE127229. Rattus norvegicus. 9 samples. Type: Expression profiling by high throughput sequencing.
Dynamic patterns of DNA methylation in the normal prostate epithelial differentiation program are targets of aberrant methylation in prostate cancer [BiSulfite-seq]
GEO Series GSE174711. Homo sapiens. 4 samples. Type: Methylation profiling by high throughput sequencing.
Cardiac phase-targeted dynamic load on left ventricle differentially regulates phase-sensitive gene expressions and pathway activation
GEO Series GSE44108. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
The spatial and temporal dynamics of the nuclear RNAi-targeted retrotransposon transcripts in Caenorhabditis elegans [RNA-seq]
GEO Series GSE118379. Caenorhabditis elegans. 12 samples. Type: Expression profiling by high throughput sequencing.
A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets
GEO Series GSE180697. Homo sapiens. 65 samples. Type: Expression profiling by high throughput sequencing.
Mechanisms Governing Target Search and Binding Dynamics of Hypoxia-Inducible Factors [RNA-seq]
GEO Series GSE207574. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
Transcription factor p63 bookmarks genomic loci in epithelial cells and regulates a subset of target genes during epidermal differentiation through dynamic enhancers (ChIP-Seq)
GEO Series GSE59824. Homo sapiens. 13 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
NOTCH1/RBPJ complexes drive target gene expression through dynamic interactions with super-enhancers
GEO Series GSE51800. Homo sapiens. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Phosphorylation of PLIN5 is dynamically regulated in mice, required for IRS2 expression in the male mice liver, but dispensable for PGC1a target genes previously associated with PLIN5
GEO Series GSE275608. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
The MicroRNAs target mitochondrial dynamics and metabolism to regulate mitochondrial-mediated antiviral innate immunity
GEO Series GSE129615. Homo sapiens. 2 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.