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3,126 results for “epithelial cells”
Pre-ciliated tubal epithelial cells are prone to initiation of high-grade serous ovarian carcinoma
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Progesterone signaling in oviductal epithelial cells modulates the immune response to support preimplantation embryonic development
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scRNA-seq of thymic epithelial cells from Aire-knockout rats
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Transcriptome profiling of medullary thymic epithelial cells from Aire-knockout rats
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Force propagation between epithelial cell doublets
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Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton
<p>Supporting Information for</p> <p>Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton</p> <p>Takaki Yamamoto, Tomoki Ishibashi, Yuko Mimori-Kiyosue, Sylvain Hiver, Naoko Tokushige, Mitsusuke Tarama, Masatoshi Takeichi, Tatsuo Shibata</p> <p>Tatsuo Shibata<br>Email: tatsuo.shibata@riken.jp</p> <p>Numerical data used for Figs. 1B, and C: </p> <p>Fig1B.csv,<br>Fig1C.csv</p> <p>Numerical data used for Fig. 1 figure supplement 1:</p> <p>Fig1S1_Collagen.csv,<br>Fig1S1_Fibronectin.csv,<br>Fig1S1_Non-coated.csv,<br>Fig1S1_PLL.csv</p> <p>Numerical data used for Figs. 2B, C and D: </p> <p>Fig2B.csv,<br>Fig2C_Blebbistatin.csv,<br>Fig2C_CK666.csv,<br>Fig2C_DMSO.csv,<br>Fig2C_Nocodazole.csv,<br>Fig2C_SMIFH2.csv,<br>Fig2D_DMSO.csv,<br>Fig2D_SMIFH2.csv</p> <p>Numerical data used for Fig. 2 figure supplement 2 A, D:</p> <p>Fig2S2A.csv,<br>Fig2S2D_NC.csv,<br>Fig2S2D_DAAM1_siRNA.csv,<br>Fig2S2D_DIAPH2_siRNA.csv</p> <p>Numerical data used for Fig. 2 figure supplement 3:</p> <p>Fig2S3A_NC.csv,<br>Fig2S3A_Myo2A_siRNA.csv,<br>Fig2S3A_Myo2B_siRNA.csv,<br>Fig2S3A_Myo2A_B_siRNA.csv,<br>Fig2S3B.csv</p> <p>Numerical data used for Fig. 2 figure supplement 4:</p> <p>Fig2S4A_NC.csv,<br>Fig2S4A_VCL_siRNA.csv,<br>Fig2S4B.csv</p> <p>Note: Fig2S2D_NC.csv, Fig2S3A_NC.csv and Fig2S4A_NC.csv represent data from the same control experiment.</p> <p>Numerical data used for Figs. 6C and D:<br>Fig6C.xls,<br>Fig6D_1.xls,<br>Fig6D_2.xls</p> <p>Numerical data used for Figs. 6 figure supplement 1:<br>Fig6S1I.xls,<br>Fig6S1J.xls</p> <p>Note: these data were also used in Figure 7 figure supplement 2A-H.</p> <p>Numerical data used for Figs. 8D and E:<br>Fig8DE.csv: </p> <p>FreeFEM++ script to perform the numerical computation used in Fig. 7 and matlab script for Fig 7 BCDFGH, and Fig. 7 figure supplement 2I: </p> <p>caco2ActiveChiralModel.edp,<br>PlotSimulationResults.m</p>
Data from: ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism detecting alteration of Septate Junction integrity in Drosophila epithelial cells
<p><span>Barrier functions of proliferative epithelia are constantly challenged by mechanical and chemical constraints. How epithelia respond to and cope with disturbances of barrier functions to allow tissue integrity maintenance is poorly characterized. Cellular junctions play an important role in this process and intracellular traffic contribute to their homeostasis. Here, we reveal that, in <em>Drosophila</em> pupal <em>notum</em>, alteration of the bi- or tricellular septate junctions (SJs) triggers a mechanism with two prominent outcomes. On one hand, there is an increase in the levels of E-cadherin, F-Actin and non-muscle Myosin II in the plane of adherens junctions. On </span><span>the other hand, β-integrin/Vinculin-positive cell contacts are reinforced along the lateral and basal membranes. We found that the weakening of SJ integrity, caused by the depletion of bi- or tricellular SJ components, alters ESCRT-III/Vps32/Shrub distribution, reduces degradation, and instead favours recycling of SJ components, an effect that extends to other recycled transmembrane protein cargoes including Crumbs, its effector β-Heavy Spectrin</span><span> Karst, and </span><span>β-integrin</span><span>. We propose a mechanism by which epithelial cells, upon sensing alterations of the septate junction</span><span>,</span><span> reroute the function of Shrub to adjust the balance of degradation/recycling of junctional cargoes and thereby compensate for barrier junction defects to maintain epithelial integrity.</span></p>
Supplement Tables of Recombinant Klotho protein protects pulmonary alveolar epithelial cells against sepsis-induced apoptosis by inhibiting the Bcl-2/Bax/caspase-3 pathway
<p>This is Supplement Tables of Recombinant Klotho protein protects pulmonary alveolar epithelial cells against sepsis-induced apoptosis by inhibiting the Bcl-2/Bax/caspase-3 pathway.</p>
Dataset published in the article: "Electrospun poly(L-lactide-co-DL-lactide) nanofibrous scaffold as substrate for ex vivo limbal epithelial cell cultivation"
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Dataset related to article "Amnion epithelial cells are an effective source of factor H and prevent kidney complement deposition in factor H deficient mice"
<p>File excel with raw data of parameters (column) for any single animal (line) of each experimental group</p>
Transcriptome analysis of T47D cells and H2A.J-KO derivatives for the paper entitled: The histone variant H2A.J is enriched in luminal epithelial gland cells
<p>H2A.J is a poorly studied mammalian-specific variant of histone H2A. We used immunohistochemistry to study its localization in various human and mouse tissues. H2A.J showed cell-type specific expression with a striking enrichment in luminal epithelial cells of multiple glands including those of breast, prostate, pancreas, thyroid, stomach, and salivary glands. H2A.J was also highly expressed in many carcinoma cell lines and in particular, those derived from luminal breast and prostate cancer. H2A.J thus appears to be a novel marker for luminal epithelial cancers. Knocking-out the H2AFJ gene in T47D luminal breast cancer cells reduced the expression of several estrogen-responsive genes which may explain its putative tumorigenic role in luminal-B breast cancer.</p>
The PLOD2/Succinate axis regulates the epithelial-mesenchymal plasticity and cancer cell stemness
<p>Aberrant accumulation of succinate has been detected in many cancers. However, the cellular function and regulation of succinate in cancer progression is not completely understood. Using stable isotope-resolved metabolomics (SIRM) analysis, we showed that the epithelial mesenchymal transition (EMT) was associated with profound changes in metabolites, including the elevation of cytoplasmic succinate levels. Treatment with cell-permeable succinate induced mesenchymal phenotypes in mammary epithelial cells and enhanced cancer cell stemness. Chromatin immunoprecipitation (ChIP) and sequence analysis showed that elevated cytoplasmic succinate levels were sufficient to reduce global 5-hydroxymethylcytosinene (5hmC) accumulation and induce transcriptional repression of EMT-related genes. We showed that expression of procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) was associated with an elevation of cytoplasmic succinate during the EMT process. Silence of PLOD2 expression in breast cancer cells reduced succinate levels and inhibited cancer cell mesenchymal phenotypes and stemness, which was accompanied by elevated 5hmC levels in chromatin. Importantly, exogenous succinate rescued cancer cell stemness and 5hmC levels in PLOD2-silenced cells, suggesting that PLOD2 promotes cancer progression at least partially through succinate. These results reveal the previously unidentified function of succinate in enhancing cancer cell plasticity and stemness.</p> <p><em><strong><span></span></strong></em></p>
Cultured renal proximal tubular epithelial cells resemble stressed/damaged kidney while supporting BKV infection
<p>Supplementary tables for the manuscript: Cultured renal proximal tubular epithelial cells resemble stressed/damaged kidney while supporting BKV infection</p> <p>The scRNA-Seq of RPTE and hTERT-RPTE cells infected by BKV (10X Genomics) is available under NCBI Bioproject PRJNA961060 (https://www.ncbi.nlm.nih.gov/bioproject/PRJNA961060)</p> <p> </p> <p> </p> <p> </p>
Epithelial Micro-Invasion Events by Streptococcus pneumoniae Drives Unique Epithelial Cell Responses
<p>RNA Sequencing dataset for Weight et al Manuscript.</p>
FB28-stained intracellular structures in butterfly wing epithelial cells in vivo
<p>We reconstructed the 3D video images of FB28-stained intracellular structures in butterfly wing epithelial cells in vivo. These videos are supplementary materials for Figure 5a and Figure 5b in a research article.</p>
Autologous T Cells With or Without Cyclophosphamide and Fludarabine in Treating Patients With Recurrent or Persistent Advanced Ovarian Epithelial Cancer, Primary Peritoneal Cavity Cancer, or Fallopian
ClinicalTrials.gov study NCT00562640. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase I Study of Autologous CAR T-Cells Targeting the B7-H3 Antigen in Recurrent Epithelial Ovarian
ClinicalTrials.gov study NCT04670068. IPD Sharing: NO. Countries: 1. Publications: 1.
Ability of a Dendritic Cell Vaccine to Immunize Melanoma or Epithelial Cancer Patients Against Defined Mutated Neoantigens Expressed by the Autologous Cancer
ClinicalTrials.gov study NCT03300843. IPD Sharing: NO. Countries: 1. Publications: 3.
The PLOD2/Succinate axis regulates the epithelial-mesenchymal plasticity and cancer cell stemness
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Epithelial polarization by the core planar cell polarity complex is exclusively non-autonomous
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.