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231 results for “functional connectivity”
Infrequent strong connections constrain connectomic predictions of neuronal function (1/3)
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Data from: An essential experimental control for functional connectivity mapping with optogenetics
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Neonatal brain dynamic functional connectivity: impact of preterm birth and association with early childhood neurodevelopment (data)
<p>Neonatal brain dynamic functional connectivity: impact of preterm birth and association with early childhood neurodevelopment</p>
Seasonality in functional connectivity: A case study with the American marten in Forillon National Park
<p>Protected areas are essential tools for reducing global biodiversity loss. To fulfill their ecological functions, protected areas must be connected to their surroundings, a requirement that is difficult to meet in landscapes intensively disturbed by anthropogenic activities. Therefore, protecting movement corridors at the edges of protected areas is crucial, especially for species with broad habitat needs, such as the American marten (<em>Martes americana</em>). However, habitat selection and space use patterns are dynamic processes, so we could expect that functional connectivity would vary temporally in response to changing environmental conditions and levels of human activities. In this study, we aimed to predict the location of movement corridors for the American marten in Forillon National Park and its periphery during two contrasted periods (snow-free: May–November; snow-covered: December–April). We used "seasonal" resource selection functions to identify core areas (interpreted as circuit "nodes") and CircuitScape to delineate movement corridors between them based on the electrical circuit theory. Habitat selection patterns differed between periods, with martens avoiding open areas, high elevations, and road proximity during the snow-free period, while avoiding areas closer to secondary roads but selecting areas closer to primary roads and housing structures during the snow-covered period. Consequently, the location of movement corridors differed partially between periods; functional connectivity was favored by the presence of forest patches for both periods, while being constrained by open environments, especially during the snow-free period. Our study highlights the importance of modeling functional connectivity at fine temporal scales to provide movement corridors that fulfill the requirements of a species at each period of its annual cycle.</p>
Data from: The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation
<p>Included are raw neuroimaging and preprocessed neural recording data from "The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation" (see Related Works section; citation will be updated after publication). Please cite this paper if you use any of these data. Refer to the linked github repository for associated code.</p> <p>Neuroimaging data is organized in BIDS format and saved as NIfTI files. We used MION (monocrystalline iron oxide nanoparticle) as a contrast agent. Functional resting state files can be found in the 'func' folder for each imaging session. The final six runs are resting state data (the first two/three are short EPI sequences used to test that MION is present in the brain; all resting state data used in our analyses consist of 300 volumes). The first three of these six runs consist of baseline data with no drug treatment. Four through six are resting state data recorded after I.M. injection of vehicle (2% DMSO in saline), dechloroclozapine (DCZ) or clozapine-N-oxide (CNO). </p> <p>Neural recording data is separated into LFP data, organized by folder, and putative single units, organized the 'Sorted neurons' folder. LFP data folders are named by subject's intial and date of recording. Single units are labeled according to this same system. All data are stored in .mat format and can be opened in MATLAB. KB2.mat files store timing information: the first event in the KBD2 file indicates the start of baseline, pre-injection data acquisition, and the second event indicates the start of post-injection treatment data. The KB3.mat files contains the timing information of the drug injection. As with the fMRI data, we treated animals with I.M. injection of vehicle, DCZ, or CNO. </p> <p>Treatment information for both modalities is as follows. Neuroimaging: 2020/03/16 Animal L DCZ 1; 2020/05/27 Animal H vehicle 1; 2020/06/01 Animal L vehicle 1; 2020/06/08 Animal H DCZ 1; 2020/06/22 Animal L DCZ 2; 2020/06/24 Animal H vehicle 2; 2020/07/06 Animal L vehicle 2; 2020/07/08 Animal H DCZ 2; 2021/10/25 Animal L CNO; 2022/01/13 Animal H CNO. Neural recordings: 2022/04/14 Animal H DCZ 1; 2022/04/21 Animal H vehicle 1; 2022/05/12 Animal H DCZ 2; 2022/05/24 Animal H vehicle 2; 2022/06/03 Animal H CNO; 2022/08/18 Animal L vehicle 1; 2022/08/25 Animal L DCZ 1; 2022/09/01 Animal L DCZ 2; 2022/09/08 Animal L vehicle 2; 2022/09/22 Animal L CNO.</p>
Data from: Functional connectivity in sympatric spiny rats reflects different dimensions of Amazonian forest-association
<p><span><strong>Aim: </strong>Understanding how the landscape influences gene flow is important in explaining biodiversity, especially when co-distributed taxa across heterogeneous landscapes exhibit species-specific habitat associations. Here, we test predictions about the effects of forest-type on population connectivity in two sympatric species of spiny rats that differ in their forest associations. Specifically, we evaluate the hypothesis that seasonal floodplain forests (<em>várzea</em>) provide linear connectivity, facilitating gene flow among individuals, while non-flooded forests (<em>terra-firme</em>) may diminish the functional connectivity.</span></p> <p><span><strong>Location:</strong> Western Amazon, South America.</span></p> <p><span><strong>Taxon:</strong> <em>Proechimys simonsi</em> (non-flooded forests, <em>terra-firme</em>) and <em>Proechimys steerei</em> (seasonal floodplain forests, <em>várzea</em>).</span></p> <p><span><strong>Methods:</strong> We analyze about 13,000 SNPs along with characterizations of landscape heterogeneity for two forest types to test for differences in the functional connectivity. Influence of the landscape and environmental variables are quantified using maximum-likelihood population effect (MLPE) models to identify the relative importance of variables in explaining the gene flow.</span></p> <p><span><strong>Results:</strong> There are significant differences in functional connectivity between species. However, the genomic data does not support the conventional hypotheses of higher connectivity for inhabitants of <em>várzea</em> than those of<em> terra-firme</em>. Stronger genetic structure in <em>P. steerei</em> than <em>P. simonsi </em>based on IBD models suggests reduced gene flow in species associated with <em>várzea</em> forests. Isolation by resistance reinforces that wetland habitats inhibit and promote the functional connectivity in <em>P. simonsi</em> and <em>P. steerei, </em>respectively, although large distances along the rivers can prevent gene flow in <em>P. steerei</em>.</span></p> <p><span><strong>Main conclusions: </strong>Interpreting differences between connectivity in taxa apparent from genetic analyses through the lens of a single dimension of Amazonian heterogeneity – that is, forest type – may be an oversimplification. Our statistical modeling and fit of the data to different models points to specific environmental and habitat differences between the ecological divergent spiny rat species that may contribute to differences in the genetic structure of these sympatric taxa.</span></p>
Remote sensing of multitemporal functional lake-to-channel connectivity and implications for water movement through the Mackenzie River Delta, Canada
<p>Dataset representing functional lake-to-channel connectivity in the Mackenzie Delta, NWT, Canada between 1984 and 2022 (final.class_20230324.feather), developed using Landsat 5, 7, and 9 optical imagery. </p> <p>Data in folders corresponds to data processing steps in scripts: https://doi.org/10.5281/zenodo.14618991</p> <p>Associated with manuscript: Remote sensing of multitemporal functional lake-to-channel connectivity and implications for water movement through the Mackenzie River Delta, Canada in WRR: Dolan, W., Pavelsky, T. M., & Piliouras, A. (2024). Remote sensing of multitemporal functional lake‐to‐channel connectivity and implications for water movement through the Mackenzie River Delta, Canada. <em>Water Resources Research</em>, <em>60</em>(4), e2023WR036614. https://doi.org/10.1029/2023WR036614</p>
Data from: Environmental and anthropogenic factors mediating the functional connectivity of the mesquite lizard along the eastern Trans-Mexican Volcanic Belt
<p>Functional connectivity, the extent to which a landscape facilitates or impedes the dispersal of individuals across the landscape, is a key factor for the survival of species. Anthropogenic activities such as urbanization, agriculture, and roads, negatively impact functional connectivity of most species, particularly low-vagility species like lizards. Here, we examine how a landscape modified by anthropogenic activities affects the functional connectivity, at both broad and fine scales, of a widely distributed generalist lizard <em>Sceloporus grammicus</em> in the eastern Trans-Mexican Volcanic Belt, Mexico. We estimated for the first time the species genetic structure, gene flow, and functional connectivity in agricultural and forest zones using genomic data, a comprehensive landscape characterization, and novel methods including gravity models. Our results showed marked genetic differentiation across the study region but also that functional connectivity is maintained for tens of kilometers despite <em>S. grammicus</em> low vagility. Specifically, we found that substrate and air temperature facilitated connectivity over broad and fine scales, respectively, while agricultural cover, relative humidity, and slope were important for connectivity and gene flow. Contrastingly, forest cover and roads favored (broad-scale) and limited (fine-scale) connectivity, likely associated with movement facilitated by small forest patches and with thermoregulation. Altogether, these results support that <em>S. grammicus</em> alternates its thermoregulatory behavior depending on the distance traveled and the habitat environmental conditions, and that it can disperse through relatively modified landscapes, mainly using agricultural zones. The information obtained is crucial to understanding the response of lizards to current anthropogenic pressures and their potential to adapt.</p>
Pairing functional connectivity with population dynamics to prioritize corridors for Southern California spotted owls
<p><strong>Aim:</strong> Land use change, climate change, and shifts to disturbance regimes make successful wildlife management challenging, particularly when ongoing urbanization constrains habitat and movement. Preserving and maintaining landscape connectivity is a potential strategy to support wildlife responding to these stressors. Using a novel model framework, we determined the population-level benefit of a set of identified potential corridors for spotted owl population viability.</p> <p><strong>Location:</strong> Southern California, United States.</p> <p><strong>Methods:</strong> Combining habitat suitability and dynamic metapopulation models, we compared the benefit of corridors to the Southern California spotted owl population, measured as the increase in the expected minimum abundance, both now and under a future climate. Our approach considered key corridor characteristics important to conservation decisions, namely, corridor irreplaceability and local population network benefit.</p> <p><strong>Results:</strong> We identified two corridors likely to increase Southern California spotted owl expected minimum abundance under current climate conditions. At the regional scale, of the 16 corridors evaluated, one corridor was irreplaceable (i.e. no other corridors in the network could provide a similar increase in abundance when the irreplaceable corridor was removed) and one corridor was identified as redundant (i.e. remaining corridors in the network can provide some of the increases in abundance offered by the removed corridor). Both putative corridors connected two large, populous, and similarly-sized patches. Additionally, we identified two more corridors at the local scale. We found that, under climate change, population declines may limit the benefit of connectivity for a range-restricted species like the spotted owl.</p> <p><strong>Main Conclusions:</strong> Our analytical approach highlights important criteria for corridor identification and prioritization, namely, irreplaceability versus redundancy, local versus regional benefit, and corridor impact in a changing landscape. With the capability of incorporating estimated functional connectivity into population dynamics, our modeling framework advances connectivity decision making for other species of conservation concern and archetypal taxa within ecological communities.</p>
Brain functional connectivity in chronic tic disorders and Gilles de la Tourette syndrome
<p>The pathophysiology of chronic tic disorder (cTD) and Gilles de la Tourette syndrome (GTS) is characterized by the dysfunction of both motor and non - motor cortico - striatal - thalamo - cortical (CSTC) circuitries, which leads to tic release and comorbids. A role of fronto - parietal network (FPN) connectivity breakdown has been postulated for tic pathogenesis, given that the FPN entertain connections with limbic, paralimbic, and CSTC networks. Our study was aimed at characterizing the FPN functional connectivity in cTD and GTS in order to assess the role of its deterioration in tic severity and the degree of comorbids. We recorded scalp EEG during resting state in patients with cTD and GTS. The eLORETA current source densities were analyzed, and the lagged phase synchronization (LPS) was calculated to estimate nonlinear functional connectivity between cortical areas. We found that the FPN functional connectivity in delta band was more detrimental in more severe GTS patients. Also, the sensorimotor functional connectivity in beta2 band was stronger in more severe cTD and GTS patients. FPN functional connectivity deterioration correlated with comorbids presence and severity in patients with GTS. Our data suggest that a FPN disconnection may contribute to the motoric symptomatology and comorbid severity in GTS, whereas sensorimotor disconnection may contribute to tic severity in cTD and GTS. Although preliminary, our study points out a differently disturbed brain connectivity between patients with cTD and GTS. This may serve as diagnostic marker and potentially interesting base to develop pharmacological and noninvasive neuromodulation trials aimed at reducing tic symptomatology.</p>
Resting-state functional connectivity matrices of various unconscious, psychedelic, and neuropsychiatric states.
<p>Functional connectivity matrices of various unconscious, psychedelic, and neuropsychiatric states.</p> <p>Conditions include:</p> <p>N2 Sleep</p> <p>Subaneshesthetic ketamine</p> <p>Deep sedation with propofol</p> <p>Surgical-level propofol anesthesia</p> <p>LSD</p> <p>N2O </p> <p>ADHD</p> <p>Bipolar disorder</p> <p>Schizophrenia</p> <p>Functional connectivity matrices with and without global signal regression are both included.</p>
Mechanisms of Non-Invasive Neuromodulation Interventions: Influence on Human Neurochemistry and Functional Connectivity
ClinicalTrials.gov study NCT02677740. IPD Sharing: NO. Countries: 1. Publications: 5.
Effects of Photobiomodularion on Brain Connectivity and Cognitive Function in Cognitive Impairment
ClinicalTrials.gov study NCT07287527. IPD Sharing: NO. Countries: 1. Publications: 1.
Individualized Functional Connectivity Targeting in aiTBS for Depression
ClinicalTrials.gov study NCT05680727. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Functional Connectivity as a Biomarker of rTMS
ClinicalTrials.gov study NCT03050801. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Anesthesia and Functional Connectivity: An Analysis of fMRI Changes
ClinicalTrials.gov study NCT02196259. IPD Sharing: UNDECIDED. Countries: 1. Publications: 12.
Functional connectivity in human auditory networks and the origins of variation in the transmission of musical systems
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Data from: Functional connectivity in sympatric spiny rats reflects different dimensions of Amazonian forest-association
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Data from: Environmental and anthropogenic factors mediating the functional connectivity of the mesquite lizard along the eastern Trans-Mexican Volcanic Belt
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Data from: Cross-boundary connections of biodiversity and ecosystem functioning in boreal ecosystems
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.