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173
datasets available to search
ShareScore release 0.9.0
Dataset results
173 results for “functional independence”
Respiratory Functions and Muscle Strength, Trunk Control, Functional Capacity and Independence in Hemiplegic Patients
ClinicalTrials.gov study NCT05290649. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Evaluating a Digital Memory Notebook App to Improve Functional Independence
ClinicalTrials.gov study NCT03453554. IPD Sharing: NO. Countries: 1. Publications: 3.
Neuropilates and Otago Exercises on Balance, Posture and Functional Independence in Chronic Stroke
ClinicalTrials.gov study NCT07293416. IPD Sharing: NO. Countries: 1. Publications: 2.
Assessment of Functional Independence and Quality of Life in Adolescents With Spina Bifid
ClinicalTrials.gov study NCT00966927. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of a Home-Based Rehabilitation on Anthropometric Measures, Sensory-Motor Functions and Independence After Spinal Cord Injury
ClinicalTrials.gov study NCT06444672. IPD Sharing: YES. Countries: 1. Publications: 16.
Data from: Drosophila clock is required in brain pacemaker neurons to prevent premature locomotor aging independently of its circadian function
Circadian clocks control many self-sustained rhythms in physiology and behavior with approximately 24-hour periodicity. In many organisms, oxidative stress and aging negatively impact the circadian system and sleep. Conversely, loss of the clock decreases resistance to oxidative stress, and may reduce lifespan and speed up brain aging and neurodegeneration. Here we examined the effects of clock disruptions on locomotor aging and longevity in Drosophila. We found that lifespan was similarly reduced in three arrhythmic mutants (ClkAR, cyc0 and tim0) and in wild-type flies under constant light, which stops the clock. In contrast, ClkAR mutants showed significantly faster age-related locomotor deficits (as monitored by startle-induced climbing) than cyc0 and tim0, or than control flies under constant light. Reactive oxygen species accumulated more with age in ClkAR mutant brains, but this did not appear to contribute to the accelerated locomotor decline of the mutant. Clk, but not Cyc, inactivation by RNA interference in the pigment-dispersing factor (PDF)-expressing central pacemaker neurons led to similar loss of climbing performance as ClkAR. Conversely, restoring Clk function in these cells was sufficient to rescue the ClkAR locomotor phenotype, independently of behavioral rhythmicity. Accelerated locomotor decline of the ClkAR mutant required expression of the PDF receptor and correlated to an apparent loss of dopaminergic neurons in the posterior protocerebral lateral 1 (PPL1) clusters. This neuronal loss was rescued when the ClkAR mutation was placed in an apoptosis-deficient background. Impairing dopamine synthesis in a single pair of PPL1 neurons that innervate the mushroom bodies accelerated locomotor decline in otherwise wild-type flies. Our results therefore reveal a novel circadian-independent requirement for Clk in brain circadian neurons to maintain a subset of dopaminergic cells and avoid premature locomotor aging in Drosophila.
Data from: Independent and interactive effects of immune activation and larval diet on adult immune function, growth and development in the greater wax moth (Galleria mellonella)
Organisms in the wild are likely to face multiple immune challenges as well as additional ecological stressors, yet their interactive effects on immune function are poorly understood. Insects are found to respond to cues of increased infection risk by enhancing their immune capacity. However, such adaptive plasticity in immune function may be limited by physiological and environmental constraints. Here, we investigated the effects of two environmental stressors – poor larval diet and an artificial parasite-like immune challenge at the pupal stage – on adult immune function, growth and development in the greater wax moth (Galleria mellonella). Males whose immune system was activated with an artificial parasite-like immune challenge had weaker immune response – measured as strength of encapsulation response – as adults compared to the control groups, but only when raised in highnutrition larval diet. Immune activation did not negatively affect adult immune response in males reared in low-nutrition larval diet, indicating that poor larval diet improved the capacity of the insects to respond to repeated immune challenges. Low-nutrition larval diet also had a positive independent effect on immune capacity in females, yet it negatively affected development time and adult body mass in both sexes. As in the nature immune challenges are rarely isolated, and adverse nutritional environment may indicate an elevated risk of infection, resilience to repeated immune challenges as a response to poor nutritional environment could provide a significant fitness advantage. This study highlights the importance of considering environmental context when investigating the effects of immune activation in insects.
Evolving therapies, neurocognitive outcomes, and functional independence in adult survivors of childhood glioma
Open the record for dataset details and reuse information.
The Effects of Fresnel Prism Glasses on Visual Perception, Balance, Gait and Functional Independence in Post-Stroke Patients
ClinicalTrials.gov study NCT07308054. IPD Sharing: NO. Countries: 0. Publications: 1.
Data from: Independent and interactive effects of immune activation and larval diet on adult immune function, growth and development in the greater wax moth (Galleria mellonella)
Open the record for dataset details and reuse information.
Data from: Drosophila clock is required in brain pacemaker neurons to prevent premature locomotor aging independently of its circadian function
Open the record for dataset details and reuse information.
Arabidopsis DXO1 links RNA turnover and chloroplast function independently of its enzymatic activity
GEO Series GSE99600. Arabidopsis thaliana. 9 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function
GEO Series GSE22623. Drosophila melanogaster. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
YTHDC1 m6A-dependent and m6A-independent functions converge to preserve DNA damage response
GEO Series GSE239333. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Functional and molecular characterization of mouse Gata2-independent hematopoietic progenitors
GEO Series GSE76254. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
BET Bromodomain Inhibition Blocks the Function of a Critical AR-Independent Master Regulator Network in Lethal Prostate Cancer
GEO Series GSE98069. Homo sapiens. 34 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Separation-of-function mutants reveal the NF-κB-independent involvement of IκBα in the regulation of intestinal stemness [RNA-Seq]
GEO Series GSE206515. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
An Ancient COI1-independent Function for Reactive Electrophilic Oxylipins in Thermotolerance [array]
GEO Series GSE141429. Arabidopsis thaliana. 3 samples. Type: Expression profiling by array.
A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent Functions
GEO Series GSE114098. Saccharomyces cerevisiae; Escherichia coli. 18 samples. Type: Other.
Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer factor-mediated zygotic genome activation [PRO-Seq]
GEO Series GSE276913. Drosophila melanogaster. 8 samples. Type: Other.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.