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2,785 results for “genotype”
MDR-TB SIT41_MIRU-VNTR genotyping dataset
<p>The table represents spoligo- and 24 loci MIRU-VNTR genotypes of MDR Mycobacterium tuberculosis strains from Bulgaria </p>
Genotypes for Neurospora nested association mapping population
<p>Genotype file that contains genotypes all the Neurospora association mapping population developed in Kronholm lab. See https://github.com/ikron/Neurospora_NAM_population</p> <p>The file is a tab-delimited text file in hapmap format and contains first contains the columns: rs alleles chrom pos strand assembly center protLSID assayLSID panel GCcode and then the subsequent columns are strains identifiers. The column 'rs' is the name of the SNP, column 'alleles' shows which two alternative bases occur, the column 'chrom' is the chromosome, column 'pos' is the coordinate, columns 'strand', 'center', 'protLSID', 'assayLSID', 'panel' and 'GCcode' contain all missing data. They are included for hapmap format compatibility. The column 'assembly' indicates the version of the Neurospora crassa reference genome that the coordinates are based on. And in this case it is NC12 for all SNPs.</p> <p>Missing data is indicated by 'N'</p>
SSR genotypes of oak parents and progeny in Pentalofos Forest Greece
<p>Two files (datasets) with multi-locus genotypes at 17 nuclear microsatellites; one containing the genotypes of all 59 adult trees within a mixed oak forest stand in the Pentalofod Forest in Evros County in Greece and the other the genotypes of 110 juvenile trees in the same stand. A comparison can be performed for parentage assignement and studies of hybridization. Oak species: <em>Quercus frainetto, Q. petraea, Q pubescens.</em></p>
Mass mortality among colony-breeding seabirds in the German Wadden Sea in 2022 due to distinct genotypes of HPAIV H5N1 clade 2.3.4.4b: data sets on phylogeographic analyses
<p>Highly pathogenic avian influenza viruses (HPAIV) of clade 2.3.4.4b of the H5 goose/Guangdong (gs/GD) lineage have repeatedly emerged in Germany since 2016. Both poultry holdings and wild birds have been heavily hit but the 2020-2021 and 2021-2022 HPAI winter seasons exceeded all previously recorded epizootics in Germany in terms of number of wild bird cases recorded, genetic diversity of viruses, and duration of virus activity. In past seasons regional massing of wild bird cases were seen at the German coasts of the Baltic and North Sea, but species mainly affected varied from season to season. In 2022 a new and, in Europe, unprecedented aspect was observed when several cormorant and seabird breeding colonies became affected since May at the Baltic Sea coast and in the Wadden Sea, respectively by HPAI H5N1 viruses.</p> <p> </p>
Changes in gene expression during germination reveal pea genotypes with either 'quiescence' or 'escape' mechanisms of waterlogging tolerance
<p>Waterlogging causes germination failure in pea (<em>Pisum sativum</em> L.). Three genotypes (BM-3, NL-2 and Kaspa) contrasting in ability to germinate in waterlogged soil were exposed to different durations of waterlogging. Whole genome RNAseq was employed to capture differentially expressing genes. The ability to germinate in waterlogged soil was associated with testa colour and testa membrane integrity as confirmed by electrical conductivity measurements. Among the most differentially regulated genes, upregulated gene tyrosine protein kinase responsible for metabolic regulation and downregulated LOX5 involved in fat metabolism indicated energy preservation in tolerant Kaspa, while in the other tolerant NL-2 subtilase family protein and PNC2 involved in protein and fat metabolism respectively showed upregulated expression suggesting energy utilization during waterlogging. By contrast, in sensitive genotype BM-3 high upregulation was recorded for the kunitz-type trypsin/protease inhibitor whose role is blocking the activity of protein metabolism leading to excessive lipid metabolism causing membrane leakage and subsequent seed damage. Pathway analyses based on gene ontologies showed seed storage protein metabolism as upregulated in tolerant genotypes and downregulated in the sensitive genotype. Understanding the tolerance mechanism provides a platform to breed for adaptation to waterlogging stress at germination in pea. </p>
Changes in gene expression during germination reveal pea genotypes with either 'quiescence' or 'escape' mechanisms of waterlogging tolerance
<p>Waterlogging causes germination failure in pea (<em>Pisum sativum</em> L.). Three genotypes (BM-3, NL-2 and Kaspa) contrasting in ability to germinate in waterlogged soil were exposed to different durations of waterlogging. Whole genome RNAseq was employed to capture differentially expressing genes. The ability to germinate in waterlogged soil was associated with testa colour and testa membrane integrity as confirmed by electrical conductivity measurements. Among the most differentially regulated genes, upregulated gene tyrosine protein kinase responsible for metabolic regulation and downregulated LOX5 involved in fat metabolism indicated energy preservation in tolerant Kaspa, while in the other tolerant NL-2 subtilase family protein and PNC2 involved in protein and fat metabolism respectively showed upregulated expression suggesting energy utilization during waterlogging. By contrast, in sensitive genotype BM-3 high upregulation was recorded for the kunitz-type trypsin/protease inhibitor whose role is blocking the activity of protein metabolism leading to excessive lipid metabolism causing membrane leakage and subsequent seed damage. Pathway analyses based on gene ontologies showed seed storage protein metabolism as upregulated in tolerant genotypes and downregulated in the sensitive genotype. Understanding the tolerance mechanism provides a platform to breed for adaptation to waterlogging stress at germination in pea. </p>
Genotype Data for "A genomic snapshot of demographic and cultural dynamism in Upper Mesopotamia during the Neolithic Transition"
<p>This repository contains genotype data from the article "<a href="https://www.science.org/doi/10.1126/sciadv.abo3609">A genomic snapshot of demographic and cultural dynamism in Upper Mesopotamia during the Neolithic Transition</a>". Dataset preparation protocols are described in the article. Here, we only include the genotype files of 13 newly published Çayönü samples in eigenstrat format.</p> <p>The 1KGYoruba suffix refers to the dataset prepared using variable positions in the Yoruba population (see the paper for details). Others are well known Human Origins and 1240K panels. </p> <p>Code and processed data related to the paper has been deposited <a href="http://doi.org/10.5281/zenodo.7086441">here</a>.</p> <p>* The first version has missing individuals. </p>
Phenotypic diversity of root architecture and genotypic variation in durum wheat under salt stress
<p>Supplementary data consists of Principal Components values for traits detected under salt and control conditions (S1); Markers' locations onto the durum wheat reference genome associated with QTL (S2); Markers associated with genes from NCBI database (S4); PCR results and alleles distribrution</p>
Microsatellite genotype data and leaf morphological data of the publication "Bidirectional gene flow between Fagus sylvatica L. and F. orientalis Lipsky despite strong genetic divergence"
<p>These data sets were used for analyses in the publication "Bidirectional gene flow between <em>Fagus sylvatica</em> L. and<em> F. orientalis</em> Lipsky despite strong genetic divergence" accepted in Forest Ecology and Management <a href="https://www.sciencedirect.com/journal/forest-ecology-and-management/vol/537/suppl/C">Volume 537</a>, 1 June 2023, 120947, <a href="https://doi.org/10.1016/j.foreco.2023.120947">https://doi.org/10.1016/j.foreco.2023.120947</a></p> <p>For details about the data, please read the corresponding ReadMe files.</p>
Labeled 17 Hardwood Species and 55 Genotypes of Populus Stomatal Images Datasets
<p>Research has indicated the potential of using machine learning algorithms to detect and measure stomata automatically. However, the current limitation for further improving and fine-tuning machine learning-based stomatal study methods is due to the small, inconsistent, and monotypic nature of stomatal datasets, which are also not easily accessible. To address this issue, our collection comprises about 11,000 unique images of hardwood leaf stomata gathered from projects conducted between 2015 and 2020-2022. The dataset includes over 7,000 images of 17 frequently encountered hardwood species, including oak, maple, ash, elm, and hickory, as well as over 3,000 images of 55 genotypes from seven Populus taxa (as detailed in Table 1). Each image has been labeled as either <em>inner guard cell walls</em> or <em>whole_stomata</em> (stomatal aperture and guard cells) and has a corresponding YOLO label file that can be transformed to other annotation formats. These images and labels are publicly available, making it easier to train machine-learning models and examine leaf stomatal traits. By utilizing our dataset, users can (1) use state-of-the-art machine learning models to identify, count, and quantify leaf stomata; (2) investigate the diverse range of stomatal characteristics across different types of hardwood trees; and (3) create new indices for measuring stomata.</p>
Genotyping of European Toxoplasma gondii strains by a new high-resolution next-generation sequencing-based method
<p>The data set comprises 164 FASTQ files generated with an Ion AmpliSeq-based genotyping method for <em>Toxoplasma gondii </em>and<em> </em>a BED file used for the design of the Ion AmpliSeq primer panel. The FASTA file named as "AmpliSeq-ME49-Reference" was used as a reference for mapping and data analysis of the FASTQ files. The GZ file named as "Tgondii_IonAmpliSeq_Results_SNPs_VCF" is a VCF file, which contains all SNPs identified within the 164 FASTQ files relative to the AmpliSeq-ME49-Reference. The VCF file was converted into a FASTA file named as "Tgondii_IonAmpliSeq_Results_SNPs", which also contains the SNPs identified within the 164 FASTQ files relative to the AmpliSeq-ME49-Reference.</p> <p>The work is published in the European Journal of Clinical Microbiology & Infectious Diseases with the title "Genotyping of European <em>Toxoplasma gondii</em> strains by a new high‑resolution next‑generation sequencing‑based method"; https://doi.org/10.1007/s10096-023-04721-7</p>
Soil C, N, P, and Frankia nifD-K RFLP genotypes distribution from Alnus tenuifolia nodules in early and late succession 2005
This dataset contains genetic characterizations of Frankia inhabiting Alnus tenuifolia nodules in early and late succession sites in the Bonanza Creek Experimental Forest (BCEF). Characterizations were done using PCR-RFLP on the nifD-K spacer region of the Frankia genome. The position of each plant and each nodule were mapped in order to examine spatial patterns in Frankia distribution within sites. Soil chemistry data, including C, N, P, and pH, were also collected from mineral and organic layers.
i2QTL HipSci Structural Variant and Short Tandem Repeat Genotypes
<p>Here we provide structural variant and short tandem repeat variant calls from 204 HipSci donors as described in the manuscript Jakubosky et al. "Discovery and quality analysis of a comprehensive set of structural variants and short tandem repeats". </p> <p><a href="https://www.biorxiv.org/content/10.1101/713198v2">https://www.biorxiv.org/content/10.1101/713198v2</a></p> <p>Jakubosky D, Smith EN, D’Antonio M, Bonder MJ, Young Greenwald WW, Matsui H, D’Antonio-Chronowska A, (Hipsci), Stegle O, Montgomery SB, DeBoever C, Frazer KA. Discovery and Quality Analysis of a Comprehensive Set of Structural Variants and Short Tandem Repeats. bioRxiv. January 2019:713198. doi:10.1101/713198.</p> <p> </p>
High density SNP genotypes (Infinium Human CytoSNP-850K v1.2 BeadChip) of ERAP2-WT and ERAP2-KO Birdshot LCL
<p>SNP genotype data was performed on DNA isolated from WT and CRISPR-Cas9 edited LCLs (ERAP2-KO) according to standard procedures using the Infinium Human CytoSNP-850K v1.2 BeadChip (Illumina, San Diego, CA, USA). SNP-array results and data analysis were carried out using NxClinical software v5.1 (BioDiscovery, Los Angeles, CA, USA). Human genome build Feb. 2009 GRCh37/hg19 was used. </p>
Supporting raw data for: The key role of the largest extant neotropical frugivore (Tapirus terrestris) in promoting admixture of plant genotypes across the landscape
<p>These files contain the supporting raw data of the journal article <strong>The key role of the largest extant neotropical frugivore (<em>Tapirus terrestris</em>) in promoting admixture of plant genotypes across the landscape</strong>. They include the geographical coordinates and genotypes (microsatellites) of 259 palm (<em>Syagrus romanzoffiana</em>) individuals analyzed in the mentioned study, as well as an example of one input file for conducting data analysis with the software COLONY 2.0. A text file (´Readme') describing this archived supporting data in further detail is also provided.</p>
Graphing and tabulating next-generation sequencing and genotyping data
<p>Making figures and tables for publication. Each zip archive contains input data, shell script to initiate and log R script, one R script for generating several graphs and tables, and the output graphs and tables themselves.</p> <p>Data was generated by whole-genome resequencing of 22 individual D.melanogaster from Sussex-LHM population and 2 from the Sussex RG line, followed by read-mapping, then genotyping with Haplotype Caller and Genomestrip.</p> <p>Locations for raw data, code, logs, extended QC data:</p> <p>Sequence reads NCBI SRA268956</p> <p>NCBI dbSNP https://www.ncbi.nlm.nih.gov/projects/SNP/snp_viewBatch.cgi?sbid=1062461</p> <p>NCBI dbVar accession number pre-release nstd134</p> <p> </p> <p>The pre-print manuscript for this data is available on biorxiv: "Whole genome resequencing of a laboratory-adapted Drosophila melanogaster population sample" http://biorxiv.org/content/early/2016/10/17/081554 doi: http://dx.doi.org/10.1101/081554</p> <p> </p>
Genotype reproducibility testing in next-generation sequencing data
<p>Code, log and results summary for testing the reproducibility of genotypes with three pairs of hemiclones in the Sussex LH<sub>M </sub><em>D.melanogaster </em>population sample. Discovery and genotyping of genomic sequence variants was done using GATK HaplotypeCaller, and Genomestrip. Numerical comparison of genotype calls within each pairs of hemiclone individuals was performed using GATK GenotypeConcordance.</p> <p> </p> <p>The pre-print manuscript for this data is available on biorxiv: "Whole genome resequencing of a laboratory-adapted Drosophila melanogaster population sample" http://biorxiv.org/content/early/2016/10/17/081554 doi: http://dx.doi.org/10.1101/081554</p>
High density genotypes of French Sheep populations
<p>Genotypes of 27 French sheep populations on the Illumina Ovine HD SNP chip.</p> <p>Dataset and results are presented in the preprint:</p> <p><strong>High density genome scan for selection signatures in French sheep reveals allelic heterogeneity and introgression at adaptive loci. </strong>Christina Marie Rochus, Flavie Tortereau, Florence Plisson-Petit, Gwendal Restoux, Carole Moreno-Romieux, Gwenola Tosser-Klopp, Bertrand Servin. bioRxiv 103010; doi: https://doi.org/10.1101/103010</p>
Physiological trait and genotype data for 1,038 outbred CFW mice
<p>R data set containing physiological trait data and genotype data for 1,038 mice from the Carworth Farms White (CFW) outbred mouse stock. These data were collected as part of a large study to assess the viability of using Carworth Farms White (CFW) mice for mapping genes and genetic loci underlying complex traits relevant to the study of human disease and psychology. The data accompany the following publication:</p> <p>Parker CC, Gopalakrishnan G, Carbonetto P, Gonzales NM, Leung E, Park YJ, Aryee E, Davis J, Blizard DA, Ackert-Bicknell CL, Lionikas A, Pritchard JK, Palmer AA. Genome-wide association study of behavioral, physiological and gene expression traits in commercially available outbred CFW mice. <em>Nature Genetics</em> <strong>48</strong>: 919–926.</p> <p>To use these data for your research, please cite this Zenodo resource, as well as the paper published in <em>Nature Genetics</em>.</p> <p>After loading these data into the R environment, e.g., by running "load(cfw.RData)", you will find R objects including:</p> <p>"pheno"—a 1,038 x 7 matrix containing the quantitative trait, or "phenotype", data. Traits include body weight, tibia length, muscle weights (EDL and soleus), and a binary indicator for abnormal bone health.</p> <p>"map"—a data frame containing information for 79,748 single nucleotide polymorphisms (SNPs) on chromosomes 1–19 genotyped in the CFW mice. All genomic positions are based on Mouse Genome Assembly 38 from the NCBI database (mm10, December 2011).</p> <p>"geno"—a 1,038 x 79,748 matrix containing genotype data for 1,038 mice at 79,748 SNPs.</p> <p>For more information on these data, please refer to the Data Dryad repository: http://dx.doi.org/10.5061/dryad.2rs41</p> <p>For code implementing QTL mapping of physiological, behavioral and gene expression phenotypes, and other analyses of these data, see: http://github.com/pcarbo/cfw</p>
Raw Genotyping data from: Variation in recombination rate and its genetic determinism in sheep populations from combining multiple genomewide datasets
<p>Data supporting :</p> <p><strong>Variation in recombination rate and its genetic determinism in sheep populations from combining multiple genomewide datasets</strong></p> <p>Morgane Petit, Jean-Michel Astruc, Julien Sarry, Laurence Drouilhet, Stephane Fabre, Carole Moreno, Bertrand Servin</p> <p>http://doi.org/10.1534/genetics.117.300123</p> <p><strong>Abstract</strong></p> <p>Recombination is a complex biological process that results from a cascade of multiple events during meiosis. Understanding the genetic determinism of recombination can help to understand if and how these events are interacting. To tackle this question, we studied the patterns of recombination in sheep, using multiple approaches and datasets. We constructed male recombination maps in a dairy breed from the south of France (the Lacaune breed) at a fine scale by combining meiotic recombination rates from a large pedigree genotyped with a 50K SNP array and historical recombination rates from a sample of unrelated individuals genotyped with a 600K SNP array. This analysis revealed recombination patterns in sheep similar to other mammals but also genome regions that have likely been affected by directional and diversifying selection. We estimated the average recombination rate of Lacaune sheep at 1.5 cM/Mb, identified about 50,000 crossover hotspots on the genome and found a high correlation between historical and meiotic recombination rate estimates. A genome-wide association study revealed two major loci affecting inter-individual variation in recombination rate in Lacaune, including the <em>RNF212</em> and<em> HEI10</em> genes and possibly 2 other loci of smaller effects including the <em>KCNJ15</em> and <em>FSHR</em> genes. Finally, we compared our results to those obtained previously in a distantly related population of domestic sheep, the Soay. This comparison revealed that Soay and Lacaune males have a very similar distribution of recombination along the genome and that the two datasets can be combined to create more precise male meiotic recombination maps in sheep. Despite their similar recombination maps, we show that Soay and Lacaune males exhibit different heritabilities and QTL effects for inter-individual variation in genome-wide recombination rates.</p> <p> </p> <p>Data files are provided in Plink format ( https://www.cog-genomics.org/plink2 ).</p> <p> </p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.