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56
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ShareScore release 0.9.0
Dataset results
56 results for “genotype-phenotype”
Genotype-phenotype associations in CRB1 bi-allelic patients: a novel mutation and a systematic review
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Data from: Detecting macroevolutionary genotype-phenotype associations using error-corrected rates of protein convergence
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Data from: The architecture of an empirical genotype-phenotype map
Recent advances in high-throughput technologies are bringing the study of empirical genotype-phenotype (GP) maps to the fore. Here, we use data from protein binding microarrays to study an empirical GP map of transcription factor (TF) binding preferences. In this map, each genotype is a DNA sequence. The phenotype of this DNA sequence is its ability to bind one or more TFs. We study this GP map using genotype networks, in which nodes represent genotypes with the same phenotype, and edges connect nodes if their genotypes differ by a single small mutation. We describe the structure and arrangement of genotype networks within the space of all possible binding sites for 525 TFs from three eukaryotic species encompassing three kingdoms of life (animal, plant, and fungi). We thus provide a high-resolution depiction of the architecture of an empirical GP map. Among a number of findings, we show that these genotype networks are "small-world" and assortative, and that they ubiquitously overlap and interface with one another. We also use polymorphism data from Arabidopsis thaliana to show how genotype network structure influences the evolution of TF binding sites in vivo. We discuss our findings in the context of regulatory evolution.
Erythropoietic Protoporphyrias: Studies of the Natural History, Genotype-Phenotype Correlations, and Psychosocial Impact
ClinicalTrials.gov study NCT01688895. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: The architecture of an empirical genotype-phenotype map
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Data from: Multivariate analysis of genotype-phenotype association
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Data from: Pleiotropy can be effectively estimated without counting phenotypes through the rank of genotype-phenotype map
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Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [scDNA-Seq]
GEO Series GSE229782. Homo sapiens; Mus musculus. 6 samples. Type: Other.
Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations
GEO Series GSE229783. Mus musculus; Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing; Other.
Unravelling Stargardt Disease (STGD1): Modelling Genotype-Phenotype Correlations and Unresolved Genetic Variants in iPSC-Derived Retinal Organoids
GEO Series GSE236097. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [bulk DNA-Seq]
GEO Series GSE229781. Mus musculus. 10 samples. Type: Other.
Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [RNA-Seq]
GEO Series GSE229780. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [scDNA-seq_MOI]
GEO Series GSE231543. Mus musculus. 5 samples. Type: Other.
Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations [DNA-seq_distribution]
GEO Series GSE231542. Mus musculus. 2 samples. Type: Other.
Integrated network analysis reveals genotype-phenotype correlations in Williams syndrome
GEO Series GSE89594. Homo sapiens. 94 samples. Type: Expression profiling by array.
Prospective Analysis of "Genotype-phenotype" Correlations Observed in a Large Cohort of Patients With Hereditary Retinal Dystrophies - GEPHIRD
ClinicalTrials.gov study NCT03662386. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Study of the Involvement of 15q11 - q13 Chromosome Region and CYFIP1 Gene in Autism. Attempt a Genotype-phenotype Correlation
ClinicalTrials.gov study NCT02862340. IPD Sharing: NO. Countries: 1. Publications: 0.
Mutation of the BTK Gene and Genotype-phenotype Correlation of Chinese Patients With X-Linked Agammaglobulinemia
ClinicalTrials.gov study NCT02234791. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Genotype-phenotype Characterization Study on Genetic Diseases With Immune and Neurological Dysfunctions
ClinicalTrials.gov study NCT06235580. IPD Sharing: NO. Countries: 1. Publications: 0.
Genotype-Phenotype Correlations in Patients With Alport Syndrome
ClinicalTrials.gov study NCT04947813. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.