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98
datasets available to search
ShareScore release 0.9.0
Dataset results
98 results for “germline mutation”
Germline Mutations in Pancreatic Adenocarcinoma
ClinicalTrials.gov study NCT03982446. IPD Sharing: NO. Countries: 1. Publications: 1.
Investigation of Tumour Spectrum of Germline Mutations in Breast and Ovarian Cancer Genes.
ClinicalTrials.gov study NCT03246841. IPD Sharing: YES. Countries: 1. Publications: 1.
INHERIT EGFR - Studying Germline EGFR Mutations
ClinicalTrials.gov study NCT01754025. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Data from: Microsatellite evolutionary rate and pattern in Schistocerca gregaria inferred from direct observation of germline mutations
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Mutation, selection, and the prevalence of the C. elegans heat-sensitive mortal germline phenotype
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Data from: Temperature effects on life-history trade-offs, germline maintenance and mutation rate under simulated climate warming
Mutation has a fundamental influence over evolutionary processes, but how evolutionary processes shape mutation rate remain less clear. In asexual unicellular organism, increased mutation rates have been observed in stressful environments and the reigning paradigm ascribes this increase to selection for evolvability. However, this explanation does not apply in sexually reproducing species, where little is known about how the environment affects mutation rate. Here we challenged experimental lines of seed beetle, evolved at ancestral temperature or under simulated climate warming, to repair induced mutations at ancestral and stressful temperature. Results show that temperature stress causes individuals to pass on a greater mutation load to their grand-offspring. This suggests that stress-induced mutation rates, in unicellular and multicellular organisms alike, can result from compromised germline DNA repair in low condition individuals. Moreover, lines adapted to simulated climate warming had evolved increased longevity at the cost of reproduction, and this allocation decision improved germline repair. These results suggest that mutation rates can be modulated by resource allocation trade-offs encompassing life-history traits and the germline and have important implications for rates of adaptation and extinction as well as our understanding of genetic diversity in multicellular organisms.
A Phase III Trial of Niraparib Versus Physician's Choice in HER2 Negative, Germline BRCA Mutation-positive Breast Cancer Patients
ClinicalTrials.gov study NCT01905592. IPD Sharing: NO. Countries: 14. Publications: 0.
Prostate Cancer Screening in Men With Germline BRCA2 Mutations
ClinicalTrials.gov study NCT02154672. IPD Sharing: NO. Countries: 1. Publications: 0.
Olaparib in Locally Advanced ER, PgR and HER2 Negative (Triple Negative) and in Locally Advanced Germline BRCA Mutation-positive Breast Cancer Patients
ClinicalTrials.gov study NCT02681562. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Niraparib and Dostarlimab for the Treatment of Germline or Somatic BRCA1/2 and PALB2 Mutated Metastatic Pancreatic Cancer
ClinicalTrials.gov study NCT04493060. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Temperature effects on life-history trade-offs, germline maintenance and mutation rate under simulated climate warming
Open the record for dataset details and reuse information.
Selective elimination of mitochondria mutations in the germline by genome editing
GEO Series GSE67371. Mus musculus. 4 samples. Type: Genome variation profiling by genome tiling array.
Germline unbalanced translocations arise from diverse mutational mechanisms including chromothripsis
GEO Series GSE68019. Homo sapiens. 57 samples. Type: Genome variation profiling by genome tiling array.
A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition
GEO Series GSE68058. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers
GEO Series GSE141142. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Portrait of early-onset breast cancer in Brazilian patients: germline mutation screening of BRCA1, BRCA2 and TP53 genes and tumor expression profiling
GEO Series GSE37126. Homo sapiens. 49 samples. Type: Expression profiling by array.
Germline ERCC6L2 mutations lead to impaired erythropoiesis and reshaping of the bone marrow niche
GEO Series GSE190542. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
A germline ETV6 mutation disrupts hematopoiesis via de novo creation of a nuclear export signal
GEO Series GSE288171. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
A Renal CpG Island Methylator Phenotype (R-CIMP) in Kidney Tumors Associated with Germline Mutations of FH and SDHB
GEO Series GSE126441. Homo sapiens. 56 samples. Type: Methylation profiling by genome tiling array.
Pediatric MDS-Associated Germline Mutations in SAMD9 and SAMD9L Impair Multiple Pathways in Primary Hematopoietic Cells
GEO Series GSE152420. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.