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1,010 results for “glucocorticoid”
Data from: Two stressors are worse than one: combined heatwave and drought affect hydration state and glucocorticoid levels in a temperate ectotherm
<p>Data sets from the paper: <a href="https://doi.org/10.1242/jeb.243777">https://doi.org/10.1242/jeb.243777</a> "Two stressors are worse than one: combined heatwave and drought affect hydration state and glucocorticoid levels in a temperate ectotherm" by Dezetter et al. 2022 ; Journal of Experimental Biology</p> <p> </p>
Glucocorticoids of European bison in relation to their status: age, dominance, social centrality and leadership
<p>Dataset for the paper "Glucocorticoids of European bison in relation to their status: age, dominance, social centrality and leadership"</p> <p>Stress is the body's response to cope with the environment and generally better survive unless too much chronic stress persists. While some studies suggest that it would be more stressful to be the dominant individual of the group, others support the opposite hypothesis. Several variables can actually affect this relationship, or even cancel it. This study therefore aims to make the link between social status and the basal level of stress of 14 wild European bison (<em>Bison bonasus, </em>L. 1758) living together. We collected faeces and measured the faecal glucocorticoid metabolites (FGM). We showed that FGM is linked to different variables of social status of European bison, specifically age, dominance rank, eigenvector centrality but also to interactions between the variables. Preferential leaders in bison, <em>i.e</em>. the older and more dominant individuals which are more central ones, are less stressed compared to other group members. Measurement of such variables could thus be a valuable tool to follow and improve the conservation of species by collecting data on FGM and other social variables and adapt group composition or environmental conditions (e.g. supplement in food) according to the FGM concentration of herd individuals.</p>
Data and code from: Great tits differ in glucocorticoid plasticity in response to spring temperature
<p>No description provided.</p> <p>This repository contains R-codes used for a project on glucocorticoid plasticity using data from a free-living great tit population. Specifically, the repository contains R-codes used in the following study:</p> <p>Hau M, Deimel C, Moiron M (2022) Great tits differ in glucocorticoid plasticity in response to spring temperature.BioRxiv (doi: 10.1101/2022.04.21.489013) Link to paper: <a href="https://www.biorxiv.org/content/10.1101/2022.04.21.489013v1">https://www.biorxiv.org/content/10.1101/2022.04.21.489013v1</a></p> <p>For any further information, please get in touch with at least one (preferably both) of the following researchers: Dr. Maria Moiron, email: <a href="mailto:mariamoironc@gmail.com">mariamoironc@gmail.com</a> Prof. Dr. Michaela Hau, email: <a href="mailto:mhau@orn.mpg.de">mhau@orn.mpg.de</a></p> <p>Code: All R code is available in the main folder and scripts are numbered in order of use from 001 to 004. Scripts titles should be self-explanatory, but each script contains a "Description of script and Instructions" section with further information.</p>
The expression of glucocorticoid and mineralocorticoid receptors in corticotroph pituitary tumors
<p>Data include the basic clinical parameters of patients with corticotroph pituitary tumors and the results of the measurements of relative expression level of NR3C1 and NR3C2 genes as well as the results of the evaluation of the expression of glucocorticoid and mineralocorticoid receptor. Gene expression was measured with qRT-PCR, protein expression was assessed with immunohistochemistry.</p>
Data from: Maranville JC, Baxter SS, Witonsky DB, Chase MA, Di Rienzo A. (2013) Genetic Mapping with Multiple Levels of Phenotypic Information Reveals Determinants of Lymphocyte Glucocorticoid Sensitivity.
<p>Genotype data for 88 African American indviduals in binary PLINK format published in </p> <p>Maranville JC, Baxter SS, Witonsky DB, Chase MA, Di Rienzo A. (2013) Genetic Mapping with Multiple Levels of Phenotypic Information Reveals Determinants of Lymphocyte Glucocorticoid Sensitivity. Am J Hum Genet. 93(4):735-743</p> <p> </p>
Data from: Stressful city sounds: glucocorticoid responses to experimental traffic noise are environmentally dependent
A major challenge in urban ecology is to identify the environmental factors responsible for phenotypic differences between urban and rural individuals. However, the intercorrelation between the factors that characterise urban environments, combined with a lack of experimental manipulations of these factors in both urban and rural areas, hinder efforts to identify which aspects of urban environments are responsible for phenotypic differences. Among the factors modified by urbanisation, anthropogenic sound, particularly traffic noise, is especially detrimental to animals. The mechanisms by which anthropogenic sound affects animals are unclear, but one potential mechanism is through changes in glucocorticoid hormone levels. We exposed adult house wrens, Troglodytes aedon, to either traffic noise or pink noise. We found that urban wrens had higher initial (pre-restraint) corticosterone than rural wrens before treatment, and that traffic noise elevated initial corticosterone of rural, but not urban, wrens. By contrast, restraint stress-induced corticosterone was not affected by noise treatment. Our results indicate that traffic noise specifically contributes to determining the glucocorticoid phenotype, and suggest that glucocorticoids are a mechanism by which anthropogenic sound causes phenotypic differences between urban and rural animals.
Data for: Compensating for a stressful pregnancy? Glucocorticoid treatment during gravidity reduces metabolic rate in female fence lizards post-parturition (In press: Hormones and Behavior)
<p>This dataset accompanies the paper "Compensating for a stressful pregnancy? Glucocorticoid treatment during gravidity reduces metabolic rate in female fence lizards post-parturition" (In press: Hormones and Behavior). A READ_ME/metadata explanation is available in Sheet 1. Address any queries to Dr. K. MacLeod, kirstyjmacleod@gmail.com.</p> <p>Abstract: Reproduction is a critical part of an animal’s life history, but one which incurs significant costs to survival and future reproductive potential. These physiological consequences are likely to be influenced by context – for example, if an individual is subject to environmental stressors, physiological and behavioral changes associated with reproduction may be altered. Glucocorticoids, hormones produced as part of the physiological response to stressors, may alter how reproduction affects female physiology and behavior, and therefore the outcomes of reproductive trade-offs. Glucocorticoids prioritize immediate survival over reproduction, for example through changes in immune function, metabolic rate, and foraging, which may reduce energy expenditure or increase energy gain. However, we previously found that female eastern fence lizards (<em>Sceloporus undulatus</em>) experiencing elevated glucocorticoid levels during gestation were nevertheless able to maintain reproductive output and body condition. Here we investigate compensatory mechanisms by which eastern fence lizard females may maintain reproduction under experimental increases in a glucocorticoid, corticosterone (CORT). We found that, although CORT-treated females had similar immune function and behavior, they had reduced metabolic rates 3-5 days post-parturition compared to control females. Given that CORT-treated females spent a similar time basking and had equal food intake compared to control females, we suggest that the reduced metabolic rate is a mechanism by which CORT-treated females maintain their energy balance and reduce the energetic costs of gestation during periods of stress. This study suggests that physiological responses to reproduction may be context-dependent and could act to minimize costs of reproduction in situations where CORT is elevated (such as during periods of environmental stress). </p>
Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single cell resolution
<p>Supplementary Tables for article "Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single cell resolution"<br> </p>
Data from: Glucocorticoids negatively relate to body mass on the short-term in a free-ranging ungulate
<p>Environmental fluctuations force animals to adjust glucocorticoids (GCs) secretion and release to current conditions. GCs are a widely used proxy of an individual stress level. While short-term elevation in GCs is arguably beneficial for fitness components, previous studies have documented that the relationship between long-term baseline GCs elevation and fitness components can vary according to ecological and individual factors and according to the life-history of the species studied. Using longitudinal data on roe deer (<em>Capreolus capreolus</em>) from two populations facing markedly different environmental contexts, we tested whether baseline GC levels negatively correlate with body mass – a trait positively associated with demographic individual performance – on the short- to long-term. In support, higher baseline GC concentrations were associated to lighter body mass, both measured during the same capture event, in adults of both populations. Overall, we showed that despite the marked environmental and demographic differences between populations and despite the between-sex differences in life history (<em>i.e.</em> reproductive tactics), the relationship between body mass and GCs is consistent across environmental contexts, but might differ according to the life history stage of an individual. This work opens promising perspectives to further explore the relationship between GC and fitness-related traits according to life history stages in free-ranging mammals across seasonal and environmental contexts. The timing and context-dependence of GC levels highlight the complexity of studying stress responses in the wild.</p>
Data for: Dietary nucleotides can prevent glucocorticoid-induced telomere attrition in a fast-growing wild vertebrate
<p><span>T<span>elomeres are chromosome protectors that shorten during eukaryotic cell replication and in stressful conditions. Developing individuals are </span>susceptible <span>to telomere erosion when their growth is fast and resources are limited. This is critical because the rate of telomere attrition in early life is linked to health and life span of adults. The metabolic telomere attrition hypothesis (MeTA) suggests that telomere dynamics can respond to biochemical signals conveying information about the organism's energetic state. Among these signals are glucocorticoids, hormones that promote catabolic processes, potentially impairing costly telomere maintenance, and nucleotides, which activate anabolic pathways through the cellular enzyme target of rapamycin (TOR), thus preventing telomere attrition. During the energetically demanding growth phase, the regulation of telomeres in response to two contrasting signals—one promoting telomere maintenance and the other attrition—provides an ideal experimental setting to test the MeTa. We studied nestlings of a rapidly developing free-living passerine, the great tit (<em>Parus</em> <em>major</em>), that either received glucocorticoids (Cort-chicks), nucleotides (Nuc-chicks), or a combination of both (NucCort-chicks), comparing these with controls (Cnt-chicks). As expected, Cort-chicks showed telomere attrition, while NucCort- and Nuc-chicks did not. NucCort-chicks was the only group showing increased expression of a proxy for TOR activation (the gene telo2), of mitochondrial enzymes linked to ATP production (cytochrome oxidase and ATP-synthase) and a higher efficiency in aerobically producing ATP. NucCort-chicks had also a higher expression of telomere maintenance genes (shelterin protein TERF2 and telomerase TERT) and of enzymatic antioxidant genes (glutathione peroxidase and superoxide dismutase). The findings show </span>that nucleotide availability is crucial for preventing telomere erosion during fast growth in stressful environments. </span></p>
Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction
ClinicalTrials.gov study NCT05462730. IPD Sharing: NO. Countries: 1. Publications: 2.
Glucocorticoid Receptor Blockade With Mifepristone in Patients With Mild Adrenal Hypercortisolism
ClinicalTrials.gov study NCT01990560. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Phase III Study of Efficacy and Safety of Secukinumab Versus Placebo, in Combination With Glucocorticoid Taper Regimen, in Patients With Polymyalgia Rheumatica (PMR)
ClinicalTrials.gov study NCT05767034. IPD Sharing: YES. Countries: 27. Publications: 1.
Glucocorticoids in COVID-19 (CORTIVID)
ClinicalTrials.gov study NCT04438980. IPD Sharing: YES. Countries: 1. Publications: 1.
Intracochlear Injection of Glucocorticoid
ClinicalTrials.gov study NCT07134075. IPD Sharing: NO. Countries: 1. Publications: 13.
Genomic Responses of Human Immune and Non-Immune Cells to Glucocorticoids
ClinicalTrials.gov study NCT02798523. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Study of Ruxolitinib in Sclerotic Chronic Graft-Versus-Host Disease After Failure of Systemic Glucocorticoids
ClinicalTrials.gov study NCT03616184. IPD Sharing: NO. Countries: 1. Publications: 1.
Genomic Effects of Glucocorticoids in Patients With Systemic Lupus Erythematosus
ClinicalTrials.gov study NCT04233164. IPD Sharing: NO. Countries: 1. Publications: 3.
Sarilumab in Patients With Glucocorticoid-Dependent Sarcoidosis
ClinicalTrials.gov study NCT04008069. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Clinical Trial of Metformin to Decrease Glucocorticoids Side Effects in Patients With Autoimmune Uveitis
ClinicalTrials.gov study NCT03525028. IPD Sharing: YES. Countries: 1. Publications: 10.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.