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348 results for “hair cells”
Data from: LHFPL5 is a key element to the gating spring of cochlear hair cells: comparison of mechanotransduction channel activation in presence or absence of LHFPL5
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The potassium channel subunit Kv1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells
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Sox2 interacts with Atoh1 and Huwe1 loci to regulate Atoh1 transcription and stability during hair cell differentiation
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Data from: Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma
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Data from: Gating-spring stiffness increases outer-hair-cell bundle stiffness, damping, and receptor current
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Microtubule networks in zebrafish hair cells facilitate presynapse transport and fusion during development
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Data for: Atoh1 is required for the formation of lateral line electroreceptors and hair cells, whereas Foxg1 represses an electrosensory fate
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Quantification of hair cell number, ribeye b and nuclei in the zebrafish inner ear endorgans
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From hidden hearing loss to supranormal auditory processing by neurotrophin 3-mediated modulation of inner hair cell synapse density
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Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy
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Rapid mechanical stimulation of inner-ear hair cells by photonic pressure
<p>Hair cells, the receptors of the inner ear, detect sounds by transducing mechanical vibrations into electrical signals. From the top surface of each hair cell protrudes a mechanical antenna, the hair bundle, which the cell uses to detect and amplify auditory stimuli, thus sharpening frequency selectivity and providing a broad dynamic range. Current methods for mechanically stimulating hair bundles are too slow to encompass the frequency range of mammalian hearing and are plagued by inconsistencies. To overcome these challenges, we have developed a method to move individual hair bundles with photonic force. This technique uses an optical fiber whose tip is tapered to a diameter of a few micrometers and endowed with a ball lens to minimize divergence of the light beam. Here we describe the fabrication, characterization, and application of this optical system and demonstrate the rapid application of photonic force to vestibular and cochlear hair cells.</p>
FIGURE. Metzgeria crassipilis (Lindb.) A. Evans I. (A) Thallus growing on a twig. (B) Thallus cells and gemmae. (C) Thallus margin. (D) Curved marginal hair. (E & F) Gemma. (G) Cross section of thallus. A–G Ruklani & Rubasinghe 117-14SR (PDA). in Thalloid Liverworts (Marchantiopsida) of Sri Lanka
FIGURE. Metzgeria crassipilis (Lindb.) A. Evans I. (A) Thallus growing on a twig. (B) Thallus cells and gemmae. (C) Thallus margin. (D) Curved marginal hair. (E & F) Gemma. (G) Cross section of thallus. A–G Ruklani & Rubasinghe 117-14SR (PDA).
Source data - inner hair cells development
<p>This is the dataset used to produce the numerical figures in the publication "Precise alternating cellular pattern in the inner ear by coordinated hopping intercalations and delaminations"</p>
Adipose-derived Stem Cell Conditioned Media as a Novel Approach for Hair Regrowth in Male Androgenetic Alopecia
ClinicalTrials.gov study NCT05296863. IPD Sharing: Not stated. Countries: 1. Publications: 31.
Adipose Tissue Derived Stem Cell Based Hair Restoration Therapy for Androgenetic Alopecia
ClinicalTrials.gov study NCT02865421. IPD Sharing: NO. Countries: 1. Publications: 1.
Rapid mechanical stimulation of inner-ear hair cells by photonic pressure
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Sensory transduction is required for development of hair cell synapses
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Avian auditory hair cell regeneration is accompanied by JAK/STAT-dependent expression of immune-related genes in supporting cells
<p>Normalized log count matrix and single cell experiment container</p>
Data from: Macrophages contribute to the cyclic activation of adult hair follicle stem cells
Skin epithelial stem cells operate within a complex signaling milieu that orchestrates their lifetime regenerative properties. The question of whether and how immune cells impact on these stem cells within their niche is not well understood. Here we show that skin-resident macrophages decrease in number because of apoptosis before the onset of epithelial hair follicle stem cell activation during the murine hair cycle. This process is linked to distinct gene expression, including Wnt transcription. Interestingly, by mimicking this event through the selective induction of macrophage apoptosis in early telogen, we identify a novel involvement of macrophages in stem cell activation in vivo. Importantly, the macrophage-specific pharmacological inhibition of Wnt production delays hair follicle growth. Thus, perifollicular macrophages contribute to the activation of skin epithelial stem cells as a novel, additional cue that regulates their regenerative activity. This finding may have translational implications for skin repair, inflammatory skin diseases and cancer.
Data from: Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells
Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' interconnecting stereocilia. To ensure maximal sensitivity, tip links are tensioned at rest, resulting in a continuous influx of Ca2+ into the cell. Here we show that this constitutive Ca2+ influx, usually considered as potentially deleterious for hair cells, is in fact essential for stereocilia stability. In the auditory hair cells of young postnatal mice and rats, a reduction in mechanotransducer current, via pharmacological channel blockers or disruption of tip links, leads to stereocilia shape changes and shortening. These effects occur only in stereocilia that harbor mechanotransducer channels, recover upon blocker washout or tip link regeneration, and can be replicated by manipulations of extracellular Ca2+ or intracellular Ca2+ buffering. Thus, our data provide the first experimental evidence for the dynamic control of stereocilia morphology by the mechanotransduction current.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.