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730 results for “high fat diet”
Table 1 in Perinatal exposure to a high-fat diet alters proopiomelanocortin, neuropeptide Y and dopaminergic receptors gene expression and the food preference in offspring adult rats
<p><b>Table 1.</b> Experimental design. The rats were fed commercial standard diet for rodents control diet or high-fat diet during pregnancy, lactation and post-weaning (up to 100 days of life).During the feeding period, rats consumed both diets (control diet and high-fat diet). The numbers in parentheses indicate the animals number in each nutritional group.</p><table><tbody><tr><th><b>Experimental Design</b></th></tr></tbody><tbody><tr><th><b>Genitors (n)</b></th><td><b>Gestation and lactation</b></td><td><b>Offspring during lactation (n)</b></td><td><b>Offspring (n)</b></td><td><b>Post-weaning (21-100° life’s day)</b></td><td><b>Food preference (102-116º life’s day)</b></td></tr><tr><th></th><td></td><td></td><td>CC (12)</td><td>Control diet</td><td>Control diet</td></tr><tr><th></th><td></td><td></td><td></td><td></td><td>High-fat diet</td></tr><tr><th>GC (5)</th><td>Control diet</td><td>C (23)</td><td>CH (11)</td><td>High-fat diet</td><td>Control diet</td></tr><tr><th></th><td></td><td></td><td></td><td></td><td>High-fat diet</td></tr><tr><th></th><td></td><td></td><td>HC (11)</td><td>Control diet</td><td>Control diet</td></tr><tr><th></th><td></td><td></td><td></td><td></td><td>High-fat diet</td></tr><tr><th>GH (5)</th><td>High-fat diet</td><td>H (23)</td><td>HH (12)</td><td>High-fat diet</td><td>Control diet</td></tr><tr><th></th><td></td><td></td><td></td><td></td><td>High-fat diet</td></tr></tbody></table>
Data of multiple different high-fat diets
<p><strong><span>Background and Objectives:</span> </strong><span>The spectrum of non-alcoholic fatty liver disease (NAFLD), known as non-alcoholic steatohepatitis (NASH), can lead to advanced liver disease. It is known that a variety of diets play a significant role in the development of NAFLD/NASH. The goal of this study is to determine the most appropriate composition of diet to induce NASH in an animal model.</span></p> <p><strong><span>Methods:</span> </strong><span>This research used <em>Rattus norvegicus</em> strain Wistar (n=27), which were divided into four groups and given each diet for 12 weeks: normal diet (ND, n=7), high-fat diet (HFD, n=6), Western diet (WD, n=7), high-fat-high-fructose diet (HFHFD, n=7). Subjects were documented for body weight. Blood samples were taken for biochemical analysis: <em>low-density lipoprotein</em> (LDL), triglyceride, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), hepatic lipase, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and lipopolysaccharide (LPS). Feces were taken for <em>short-chain fatty acid</em> (SCFA) analysis. Liver histology was analyzed using NAS (NAFLD activity score). The comparison test was carried out using the one-way ANOVA or Kruskal–Wallis test.</span></p> <p><span><strong>Results:</strong> </span><span>The highest mean of body weight was in the WD group (</span><span>346.14 g). </span><span>Liver enzymes, LDL, triglyceride, propionic acid, and acetic acid in each group were not significantly different. TNF-α, IL-6, and hepatic lipase were significant (p = 0.000; p = 0.000; p = 0.004) and the highest was in the HFD group. Butyrate level was significant (</span><span>p = 0.021) and</span><span> the least was in the HFHFD group (</span><span>4.77 mMol/g). O</span><span>nly WD and HFHFD had an NAS ≥ 5 (14% and 14%). The highest percentage of borderline NAS was found in WD (57%). </span></p> <p><strong><span>Conclusions:</span></strong><span> The HFD group induced significant liver inflammation but did not produce NASH histologically, whereas the WD and HFHFD groups had the potential to develop NASH because the diets affected metabolic and inflammatory parameters as well as liver histology.</span></p>
Gut microbe compositions in High Fat diet
<p>This study aimed to explore the relationship between the gut microbiome and liver function, with the objective of identifying a specific bacterial species that may exhibit beneficial effects in improving the symptoms of NAFLD. We conducted a comparative analysis of the gut microbiome composition between mice fed a normal chow (NC) diet and mice fed a high-fat (HF) diet in order to identify specific gut microbes. The consumption of a high-fat diet led to a decrease in the prevalence of Kineothrix bacteria. To assess the effects of Kineothrix on liver health, we conducted a comparative analysis of the gut microbiome composition between mice fed a diet high in fat and fructose (HFHF), with and without the administration of Kineothrix.</p>
High Fat Diet for Cardiac Metabolic Reprogramming
ClinicalTrials.gov study NCT06747429. IPD Sharing: NO. Countries: 0. Publications: 13.
Gut microbiome analysis of high fat diet- and control-fed on PXR-KO mice
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Data from: anterior pituitary transcriptomics following a high fat diet: impact of oxidative stress on cell metabolism
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Data from: Medium-chain fatty acid receptor GPR84 deficiency leads to metabolic homeostasis dysfunction in mice fed high-fat diet
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Feeding foliar nano-selenium biofortified Panax notoginseng could reduce the occurrence of glycolipid metabolism disorder in mice caused by high-fat diets
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Astaxanthin from Haematococcus pluvialis prevents high-fat diet-induced hepatic steatosis and oxidative stress in mice by gut-liver axis modulating properties
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Data of multiple different high-fat diets
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High-fat and high-sugar diets induce rapid adaptations of fat storage in the house fly Musca domestica L
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Untargeted LC–MS metabolomics reveals an adverse effect of high-fat diet on hepatic metabolism of Oreochromis niloticus
<p>Hepatic steatosis commonly occurs in intensively farmed tilapia. This disease is harmful to fish growth and health, but knowledge of the metabolic changes in tilapia with fatty liver is limited. In the present study, we compared genetically improved farmed tilapia (GIFT, <em>Oreochromis niloticus</em>) fed a high-fat diet (HFD) with those fed a normal-fat diet (NFD) for 8 weeks using LC-MS-based hepatic metabolomic assays and traditional nutritional assessments. Juvenile GIFT fed a HFD displayed higher fat disposition in the liver than did those fed a NFD. The metabolomic analyses revealed 61 differentially accumulated metabolites between the groups, and these metabolites were involved in 37 signaling pathways. Our results illustrate the development of metabolic disorders related to various hepatic biological processes, including protein metabolism, lipid metabolism, carbohydrate metabolism, and nucleotide metabolism in HFD-fed GIFT. These physiological changes may be related to the lower growth rate of GIFT. Overall, our study reveals the metabolic disorders in GIFT fed HFD, and enhance our knowledge of the mechanism of fatty liver formation in GIFT.</p>
Genetic regulatory effects in response to a high cholesterol, high fat diet in baboons
<p>Disease-associated loci discovered through genome-wide association studies (GWAS) are primarily located in non-coding regions with putative regulatory effects on gene expression. Steady-state, standard expression quantitative trait loci (eQTLs) explain only a limited portion of GWAS signals, while eQTLs involved in gene-by-environment (GxE) interactions have rarely been characterized in humans due to experimental challenges. Here, we characterized gene-by-diet effects in a baboon model system. By analyzing three tissue types obtained from 99 captive baboons, we identify hundreds of diet-responsive eQTLs with high tissue specificity. Diet-responsive eQTLs exhibit genomic localization and genic features that are distinct from steady-state eQTLs. Furthermore, the human orthologs of genes associated with diet-responsive eQTLs are enriched for GWAS genes associated with human metabolic traits, suggesting that context-responsive eQTLs with more complex regulatory effects are likely to explain GWAS hits that do not seem to overlap with standard eQTLs. Our results highlight the dynamic complexity of genetic regulatory effects and the potential of eQTLs with disease-relevant GxE interactions in enhancing the understanding of GWAS signals for human complex disease using the baboon model.</p>
Therapeutic Potential of Nigella sativa Extract against Inflammatory Markers Interleukin-1ß (IL-1ß) and Tumor Necrosis Factor-α (TNF-α) in Rat Models with High Fat Diet
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16S rDNA sequence data of research--Different periods of high-fat diet during peri-pregnancy cause variant offspring gut microbiota
<p> These are the 16S rRNA gene sequencing data based on the Illumina HiSeq2500 platform. Group a, b, c, d stand for group CD-CD, CD-HFD, HFD-CD, HFD-HFD separately. Each mouse of one group had two samples such as a1_1 and a1_2.</p>
A low molecular weight Saccharina japonica polysaccharide suppresses high fat diet-induced obesity and enriches gut bacteria with fucoidan-degrading potential
<p>This dataset contains 16S rRNA gene and metagenomic sequencing raw data involved in this study. Metagenomic data (S21H1887, S21H1888) were obtained from two cecal content samples from the LFD_J2H group due to<em> Akkermansia</em> uncultured bacterium was highly abundant in these samples. In addition, the code for JS divergence analysis is included.</p>
The effect of dietary supplementation with blueberry, cyanidin-3-O-β-glucoside, yoghurt and its peptides on gene expression associated with glucose metabolism in skeletal muscle obtained from a high-fat-high-carbohydrate diet induced obesity model
<p><span>Obesity is a leading global health problem contributing to various chronic diseases, including type II diabetes mellitus</span> <span>(T2DM). The aim of this study was to investigate whether blueberries, yoghurt, and their respective bioactive components, Cyanidin-3-O-β-glucoside (C3G) and peptides alone or in combinations, alter the expression of genes related to glucose metabolism in skeletal muscles from diet-induced obese mice. In extensor digitorum longus (EDL), yoghurt up-regulated the expression of activation of 5'adenosine monophosphate-activated protein kinase (AMPK), insulin receptor substrate-1 (IRS-1), phosphatidylinositol-3 kinase (PI3K) and glucose transporter 4 (GLUT4), and down-regulated the expression of angiotensin II receptor type 1 (AGTR-1). The combination of blueberries and yoghurt down-regulated the mRNA expression of AGTR-1 and Forkhead box protein O1 (FoxO1) in the EDL. Whereas the combination of C3G and peptides down-regulated AGTR-1 and up-regulated GLUT4 mRNA expression in the EDL. In the soleus, blueberries and yoghurt alone, and their combination down-regulated AGTR-1 and up-regulated GLUT4 mRNA expression. In summary blueberries and yoghurt, regulated multiple genes associated with glucose metabolism in skeletal muscles, and therefore may play a role in the management and prevention of T2DM.</span></p>
Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short term high fat diet
<p>Cardiac metabolic flexibility is essential for proper function. Under pathological conditions, such as diabetes, the heart increases reliance on fatty acid oxidation at the expense of glucose metabolism. Thus, restoring or enhancing glucose usage may provide a therapeutic strategy. In this study we sought to identify how the cardiac proteomic profile is affected basally and after a short term high fat diet (7d) in wild type and a transgenic model of enhanced glycolysis (Glyco<sup>Hi</sup>). Targeted quantitative proteomics and cluster analysis revealed revealed Glyco<sup>Hi</sup> mice have increased protein expression of glycolytic enzymes and that this was sustained with the high fat diet challenge. Glyco<sup>Hi</sup> mice also had significantly increased expression of pyruvate dehydrogenase kinase 4 (PDK4), an enzyme that regulates the overall rate of glucose oxidation. These results support that Glyco<sup>Hi</sup> mice have the capacity to increase glycolysis when challenged with a nutrient stress but that there is a compensatory increase in PDK4 that may limit the overall rate of glucose oxidation.</p>
Reno-protective Effects of Empagliflozin in High Fat Diet Induced Obesity-Related Glomerulopathy by Regulation of Gut-Kidney Axis
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Grape Polyphenols may prevent high fat diet-induced dampening of the hypothalamic-pituitary-adrenal axis in male mice
<p>Supplementary Materials. </p>
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