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335 results for “high-fat diet”
Effects of a PUFA-rich Diet on Acute Metabolic and Inflammatory High-Fat Meal Responses
ClinicalTrials.gov study NCT02246933. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Feasibility of a Carbohydrate-restricted, High-fat Diet on Head and Neck Squamous Cell Carcinoma Outcomes
ClinicalTrials.gov study NCT04253808. IPD Sharing: NO. Countries: 1. Publications: 1.
Untargeted LC–MS metabolomics reveals an adverse effect of high-fat diet on hepatic metabolism of Oreochromis niloticus
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Data and code from: Multigenerational exposure to high-fat and high-sugar diets exacerbates reproductive distress in an insect model
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Data from: Curcumin improves glycolipid metabolism through regulating peroxisome proliferator activated receptor γ signalling pathway in high-fat diet-induced obese mice and 3T3-L1 adipocytes
Curcumin, an active component derived from the Curcuma longa L. which is a traditional Chinese medicine that is widely used for treating metabolic diseases through regulating different molecular pathway. Here, in this study, we aimed to comprehensively investigate the effects of curcumin on glycolipid metabolism in vivo and in vitro and then determine the underlying mechanism. Male C57BL/6J obese mice and 3T3-L1 adipocytes were used in vivo and in vitro study, respectively. Our results demonstrated that treatment with curcumin for 8 weeks decreased body weight, fat mass and serum lipid profiles. Meanwhile, it lowered fasting blood glucose and increased the insulin sensitivity in high-fat diet induced obese mice. In addition, curcumin stimulated lipolysis and improve glycolipid through upregulating the expressions of ATGL, HSL, PPARγ, C/EBPα and PPARα in adipose tissue of the mice. In differentiated 3T3-L1 cells, curcumin reduced glycerol release and increased glucose uptake via upregulating PPARγ and C/EBPα. We concluded that curcumin has potential to improve glycolipid metabolism disorders caused by obesity through regulating PPARγ signaling pathway.
Figure 2 from: Issa R, Abu Samak M, Abbas MM, Al-Qaisi T, Obeidat R, Ghanim B, Qinna N (2024) Effect of Equisetum ramosissimum Desf. on body weight and Leptin/Ghrelin in standard and high-fat diet. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e117823
Figure 2 Percent Body Weight change in healthy and obese animals treated with E. ramosissimum extract. Comparison of weight change was made between: Standard Diet (SD); SD receiving Plant extract (SDP); High-fat Diet (HD); and HD receiving Plant extract (HDP). ***: p<0.001 in comparison to SD, as calculated through t-test.
Figure 3 from: Issa R, Abu Samak M, Abbas MM, Al-Qaisi T, Obeidat R, Ghanim B, Qinna N (2024) Effect of Equisetum ramosissimum Desf. on body weight and Leptin/Ghrelin in standard and high-fat diet. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e117823
Figure 3 Serum concentrations of leptin and ghrelin and their corresponding ratios. Serum concentrations of leptin and ghrelin and their corresponding ratios were quantified for animals receiving Standard Diet (SD); SD receiving Plant extract (SDP); High-fat Diet (HD); and HD receiving Plant extract (HDP). Ratios of leptin/ghrelin were calculated and presented in normalized values to the standard body levels (right y-axis), specifically per animals receiving SD. **: p<0.01; *p<0.05 in comparison to SD.
Figure 1 from: Issa R, Abu Samak M, Abbas MM, Al-Qaisi T, Obeidat R, Ghanim B, Qinna N (2024) Effect of Equisetum ramosissimum Desf. on body weight and Leptin/Ghrelin in standard and high-fat diet. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e117823
Figure 1 Total Phenol and Flavonoid content in E. ramosissimum extract. Extracts are quantified against equivalent quantities of reference standards, specifically Gallic acid and quercetin, respectively.
Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
<p>Abstract. The healthy heart adapts to changes in nutrient availability and energy demands. In metabolic diseases like type 2 diabetes (T2D), increased reliance on fatty acids for energy production contributes to mitochondrial dysfunction and cardiomyopathy. A principal regulator of cardiac metabolism is 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2), which is a central driver of glycolysis. We hypothesized that increasing PFK-2 activity could mitigate cardiac dysfunction induced by high fat diet (HFD). Wild type (WT) and cardiac-specific transgenic mice expressing PFK-2 (Glyco<sup>Hi</sup>) were fed a low fat or HFD for 16-weeks to induce metabolic dysfunction. Metabolic phenotypes were determined by measuring mitochondrial bioenergetics and performing targeted quantitative proteomic and metabolomic analysis. Increasing cardiac PFK-2 had beneficial effects on cardiac and mitochondrial function. Unexpectedly, Glyco<sup>Hi</sup> mice also exhibited sex-dependent systemic protection from HFD, including increased glucose homeostasis. These findings support improving glycolysis via PFK-2 activity can mitigate mitochondrial and functional changes that occur with metabolic syndrome.</p> <p>There are two types of data in this upload, proteomics and metabolomics.</p> <p>The proteomics data are raw files acquired on a tsq quantiva triple quadrupole mass spectrometer in the SRM mode at OMRF. Each file is panel of protein assays. Please contact Mike Kinter with questions.</p> <p>The metabolomics data are more processed data files as described in the paper. Please contact Haiwei Gu with questions.</p>
The Effect of 6 Weeks Saturated and Polyunsaturated High-Fat Diets on Insulin Sensitivity and Health Parameters
ClinicalTrials.gov study NCT03561363. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Data from: Curcumin improves glycolipid metabolism through regulating peroxisome proliferator activated receptor γ signalling pathway in high-fat diet-induced obese mice and 3T3-L1 adipocytes
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High-Fat Diet Driven Post-Operative Colon Cancer Recurrence is Dependent upon Genetic Susceptibility to Deoxycholic Acid [tRNA-seq]
GEO Series GSE288276. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Effects of hepatocyte-restricted Fra-1 overexpression on hepatic gene expression in High-fat diet (HFD) fed mice
GEO Series GSE52273. Mus musculus. 5 samples. Type: Expression profiling by array.
Gene expression profile at single cell level of bone marrow and brain cells from young adult and aged mouse after chewing diet (CD) and long-term high-fat diet (HFD) feeding
GEO Series GSE217560. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profilling of liver from C57BL/6 wildtype and PPARα-knockout mice treated with PFOA and GenX after 20 weeks of high-fat diet
GEO Series GSE212294. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Acquired paternal inheritance fatty liver transcriptomes induced by high-fat diet
GEO Series GSE111909. Gallus gallus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiling of non-islet metabolic tissues in ~500 DO mouse liver, adipose, heart, and skeletal muscle tissue from mice fed high-fat, high-sugar diet. [Liver]
GEO Series GSE266569. Mus musculus. 481 samples. Type: Expression profiling by high throughput sequencing.
Maternal high-fat diet alters the characteristics of astrocytes and worsens the outcome of stroke in rat offspring, which improves after FGF21 administration
GEO Series GSE189679. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
A maternal high-fat diet induces fetal origins of NASH-HCC in mice
GEO Series GSE183360. Mus musculus. 4 samples. Type: Expression profiling by array.
RNA-sequencing of inguinal white adipose tissue (iWAT) from kynurenine 3-monooxygenase (Kmo) knockout mice and wild-type littermates on chow and high-fat diets.
GEO Series GSE277692. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
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DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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