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76 results for “host condition”
Out of the ‘host’ box: Extreme off-host conditions alter the infectivity and virulence of a parasitic bacterium
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Data from: Pliant pathogens: estimating viral spread when confronted with new vector, host, and environmental conditions
<p>1. Pathogen spread rates are determined, in part, by the performance of pathogens under altered environmental conditions and their ability to persist while switching among hosts and vectors.</p> <p>2. To determine the effects of new conditions (host, vector, and nutrient) on pathogen spread rate, we introduced a vector-borne, viral plant pathogen, Barley Yellow Dwarf Virus PAV (BYDV-PAV) into hosts, vectors, and host nutrient supplies that it had not encountered for thousands of viral generations. We quantified pathogen prevalence over the course of two serial inoculations under the new conditions. Using individual level transmission rates from this experiment, we parameterized a dynamical model of disease spread and projected spread across host populations through a growing season. </p> <p>3. A change in nutrient conditions (increased supply of phosphorus) reduced viral transmission whereas shifting to a new vector or host species had no effect on infection prevalence. However, the reduction in the new nutrient environment was only temporary; infection prevalence recovered after the second inoculation.</p> <p><i>4. Synthesis</i>. These results highlight how robust the pathogen, BYDV-PAV, is to changes in its biotic and abiotic environment. Our study also highlights the need to quantify longitudinal infection information beyond snapshot assessments to project disease risk for pathogens in new environments.</p>
Cultivation of host-associated bacteria under sulfide-enriched microoxic and anoxic conditions
<p>Three images of cell colonies on culture plates inoculated with gill tissue homogenate from <em>Bathymodiolus brooksi</em>. The colonies grew under the following conditions: </p> <ul> <li>IMG_2467: microoxic, low H2S, low ammonium</li> <li>IMG_2468: microoxic, low H2S, low ammonium, organics</li> <li>IMG_2474: microoxic, low H2S, high ammonium, organics, 1 mM thiosulfate</li> </ul> <p>Image of a control plate without cultures inoculated with heat sterilized aliquot of <em>Bathymodiolus brooksi</em> gill homogenate:</p> <ul> <li>IMG_2475</li> </ul> <p>Two images of pH controls plated with homogenization medium that did not contain gill homogenate:</p> <ul> <li>IMG_2477: phenol red</li> <li>IMG_2479: bromothymol blue</li> </ul> <p>Two close up photos of colonies on agar plates</p> <ul> <li>IMG_2485</li> <li>IMG_2488</li> </ul>
Microclimate and host body condition influence mite population growth in a wild bird-ectoparasite system
<p>Parasite populations are never evenly distributed among the hosts they infect. Avian nest ectoparasites, such as mites, are no exception, as their distribution across the landscape is highly aggregated. It remains unclear if this pattern is driven by differences in transmission events alone, or if the environment that parasites inhabit after transmission also plays a role. Here, we experimentally examined the influence of the post-transmission microclimate, nest characteristics, and host condition on ectoparasite population growth in a bird-ectoparasite system. We infested barn swallow (Hirundo rustica erythrogaster) nests with a standardized number of Northern Fowl Mites (Ornithonyssus sylvarium) and analyzed both biotic (nestling mass, wing length, number of other arthropods present in the nest, and brood size) and abiotic (temperature, humidity, nest lining, nest dimensions, and substrate upon which the nest was built) predictors of mite population growth. Our results suggest that mite populations were most successful, in terms of growth, in nests with higher temperatures, lower humidity, few other arthropods, and hosts in good condition. We also found that nests built on wooden substrates support larger populations of mites than those constructed on metal or concrete. These findings lend insight into the factors that drive large-scale patterns of ectoparasite distributions.</p>
Hosts winnow symbionts with multiple layers of absolute and conditional discrimination mechanisms
<p>In mutualism, hosts select symbionts via partner choice and preferentially direct more resources to symbionts that provide greater benefits via sanctions. At the initiation of symbiosis, prior to resource exchange, it is not known how the presence of multiple symbiont options (i.e., the symbiont social environment) impacts partner choice outcomes. Furthermore, little research addresses whether hosts primarily discriminate among symbionts via sanctions, partner choice or a combination. We inoculated the legume, <em>Acmispon</em> <em>wrangelianus</em>, with 28 pairs of fluorescently labeled <em>Mesorhizobium</em> strains that vary continuously in quality as nitrogen-fixing symbionts. We find that hosts exert robust partner choice, which enhances their fitness. This partner choice is conditional such that a strain's success in initiating nodules is impacted by other strains in the social environment. This social genetic effect is as important as a strain's own genotype in determining nodulation and has both transitive (consistent) and intransitive (idiosyncratic) effects on the probability that a symbiont will form a nodule. Furthermore, both absolute and conditional partner choice act in concert with sanctions, among and within nodules. Thus, multiple forms of host discrimination act as a series of sieves that optimize host benefits and select for costly symbiont cooperation in mixed symbiont populations.</p>
Data from: Host genetic diversity and body condition influence parasite resistance and clearance in a wild marine mammal population
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Data from: Pliant pathogens: Estimating viral spread when confronted with new vector, host, and environmental conditions
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Hosts winnow symbionts with multiple layers of absolute and conditional discrimination mechanisms
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Microclimate and host body condition influence mite population growth in a wild bird-ectoparasite system
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Host species and age-specific variation on Hepatozoon prevalence and its effect on body condition in two Neotropical crocodiles
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Data from Pliant pathogens: Estimating viral spread when confronted with new vector, host, and environmental conditions
To determine the effects of new conditions (host, vector, and nutrient) on pathogen spread rate, we introduced a vector-borne viral plant pathogen, Barley Yellow Dwarf Virus PAV (BYDV-PAV) into hosts, vectors, and host nutrient supplies that it had not encountered for thousands of viral generations. We quantified pathogen prevalence over the course of two serial inoculations under the new conditions.
Data from: The relationship between parasite fitness and host condition in an insect - virus system
Research in host-parasite evolutionary ecology has demonstrated that environmental variation plays a large role in mediating the outcome of parasite infection. For example, crowding or low food availability can reduce host condition and make them more vulnerable to parasite infection. This observation that poor-condition hosts often suffer more from parasite infection compared to healthy hosts has led to the assumption that parasite productivity is higher in poor-condition hosts. However, the ubiquity of this negative relationship between host condition and parasite fitness is unknown. Moreover, examining the effect of environmental variation on parasite fitness has been largely overlooked in the host-parasite literature. Here we investigate the relationship between parasite fitness and host condition by using a laboratory experiment with the cabbage looper Trichoplusia ni and its viral pathogen, AcMNPV, and by surveying published host-parasite literature. Our experiments demonstrated that virus productivity was positively correlated with host food availability and the literature survey revealed both positive and negative relationships between host condition and parasite fitness. Together these data demonstrate that contrary to previous assumptions, parasite fitness can be positively or negatively correlated with host fitness. We discuss the significance of these findings for host-parasite population biology.
Cultivation of host-associated bacteria under sulfide-enriched microoxic and anoxic conditions
<p>Cultivation protocol</p>
Fluctuating starvation conditions modify host-symbiont relationship between a leaf beetle and its newly identified gregarine species
<p class="MsoNormal"><span>Gregarines are ubiquitous endosymbionts in invertebrates, including terrestrial insects. However, the biodiversity of gregarines is probably vastly underestimated and the knowledge about their role in shaping fitness-related traits of their host in dependence of fluctuating environmental conditions is limited. Using morphological and molecular analyses, we identified a new gregarine species, <em>Gregarina cochlearium</em> sp. n., in the mustard leaf beetle, <em>Phaedon cochleariae</em>. Applying a full-factorial design, we investigated the effects of a gregarine infection in combination with fluctuating starvation conditions during the larval stage on the development time and fitness-related traits of adult beetles. Under benign environmental conditions, the relationship between gregarines and the host seemed neutral, as host development, body mass, reproduction and survival were not altered by a gregarine infection. However, when additionally exposed to starvation, the combination of gregarine infection and this stress resulted in the lowest reproduction and survival of the host, which points to a parasitic relationship. Furthermore, when the host experienced starvation, the development time was prolonged and the adult females were lighter compared to non-starved individuals, independent of the presence of gregarines. Counting of gregarines in the guts of larvae revealed a lower gregarine load with increasing host body mass under stable food conditions, which indicates a regulation of the gregarine burden in dependence of the host condition. Contrary, in starved individuals the number of gregarines was the highest, hence the already weakened host suffered additionally from a higher gregarine burden. This interactive effect between gregarine infection and fluctuating starvation conditions led to an overall reduced fitness of <em>P. cochleariae</em>. Our study emphasises the need to study endosymbionts as important components of the natural environment and to investigate the role of host-symbiont relationships under fluctuating environmental conditions in an evolutionary and ecological context.</span></p>
Ecological conditions predict the intensity of Hendra virus excretion over space and time from bat reservoir hosts
<p>The ecological conditions experienced by wildlife reservoirs affect infection dynamics and thus the distribution of pathogen excreted into the environment, which have been hypothesized to shape risks of zoonotic spillover. However, few systems have data on both long-term ecological conditions and pathogen excretion to advance mechanistic understanding and test environmental drivers of spillover risk. We here analyze three years of Hendra virus data from nine Australian flying fox roosts with covariates derived from long-term studies of bat ecology. We show that the magnitude of winter pulses of viral excretion, previously considered idiosyncratic, are most pronounced after recent food shortages and in bat populations displaced to novel habitats. We further show that cumulative pathogen excretion over time is shaped by bat ecology and positively predicts spillover frequency. Our work emphasizes the role of reservoir host ecology in shaping pathogen excretion and provides a new approach to estimate spillover risk.</p>
Datasets from Benhamou et al.: Cytotype conditions capability to feed and oviposit of the whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) MED species on an unfavorable host plant
<p>This excel file contains all datasets generated analyzed in this study.</p>
Data for: Genomic heterozygosity is associated with parasite abundance, but the effects are not mediated by host condition
<p>Whether, when, and how genetic diversity buffers individuals and populations against infectious disease risk is a critical and open question for understanding wildlife disease and zoonotic disease risk. Several, but not all, studies have found negative relationships between infection and heterozygosity in wildlife. Since they can host multiple zoonotic infections, we sampled a population of wild deer mice (<em>Peromyscus maniculatus</em>), sequenced their genomes, and examined their fecal samples for coccidia and nematode eggs. We analyzed coccidia infection status, abundance, and coinfection status in relation to per-locus and per-individual measures of heterozygosity, as well as identified SNPs associated with infection status. Since heterozygosity might affect host condition, and condition is known to affect immunity, it was included as a co-variate in the per-individual analyses and as response variable in relation to heterozygosity. Not only did coccidia-infected individuals have lower levels of genome-wide per-locus diversity across all metrics, but we found an inverse relationship between genomic diversity and severity of coccidia infection. We also found weaker evidence that coinfected individuals had lower levels of private allelic variation than all other groups. In the per-individual analyses, relationships between heterozygosity and infection were marginal but followed the same negative trends. Condition was negatively correlated with infection, but was not associated with heterozygosity, suggesting that effects of heterozygosity on infection were not mediated by host condition in this system. Association tests identified multiple loci involved in the inflammatory response, with a particular role for NF-κB signaling, supporting previous work on the genetic basis of coccidia resistance. Taken together, we find that increased genome-wide neutral diversity, the presence of specific genetic variants, and improved condition positively impact infection status. Our results underscore the importance of considering host genomic variation as a buffer against infection, especially in systems that can harbor zoonotic diseases.</p>
Supplementary material 6 from: Rusch JC, Strand DA, Laurendz C, Andersen T, Johnsen SI, Edsman L, Vrålstad T (2022) Exploring the eDNA dynamics of the host-pathogen pair Pacifastacus leniusculus (Decapoda) and Aphanomyces astaci (Saprolegniales) under experimental conditions. NeoBiota 79: 1-29. https://doi.org/10.3897/neobiota.79.82793
Agent levels of Aphanomyces astaci in individuals of Pacifastacus leniusculus used in the experiment
Data from: Shifting effects of host physiological condition following pathogen establishment
<p>Understanding host persistence with emerging pathogens is essential for conserving populations. Hosts may initially survive pathogen invasions through pre-adaptive mechanisms. However, whether pre-adaptive traits are directionally selected to increase in frequency depends on the heritability and environmental dependence of the trait and the costs of trait maintenance. Body condition is likely an important pre-adaptive mechanism aiding in host survival, although it can be seasonally variable in wildlife hosts. We used data collected over seven years on bat body mass, infection, and survival to determine the role of host body condition during the invasion and establishment of the emerging disease, white-nose syndrome. We found that when the pathogen first invaded, bats with higher body mass were more likely to survive, but this effect dissipated following the initial epizootic. We also found that heavier bats lost more weight over winter, but fat loss depended on infection severity. Lastly, we found mixed support that bat mass increased in the population after pathogen arrival; high annual plasticity in individual bat masses may have reduced the potential for directional selection. Overall, our results suggest that some factors that contribute to host survival during pathogen invasion may diminish over time, and are potentially replaced by other host adaptations.</p>
FIG. 2 in Host-parasite relationships between a Malagasy fruit bat (Pteropodidae) and associated bat fly (Diptera: Nycteribiidae): seasonal variation of host body condition and the possible impact of parasite abundance
FIG. 2. Body Condition Index (BCI) of R. madagascariensis in the Grotte des Chauves-souris, Parc National d'Ankarana, based on five different field sessions and separated into the different age and sex classes. AF = adult female, AM = adult male, NF = neonate female, NM = neonate male, SAF = sub-adult female, SAM = sub-adult male
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.