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92
datasets available to search
ShareScore release 0.9.0
Dataset results
92 results for “host pathogen interaction”
Data from: Land cover and forest connectivity alter the interactions among host, pathogen and skin microbiome
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Data from: Context-dependent interactions between pathogens and a mutualist affect pathogen fitness and mutualist benefits to hosts
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Data from: Environmentally dependent host-pathogen and vector-pathogen interactions in the barley yellow dwarf virus pathosystem
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Data from: Thermal variability and plasticity drive the outcome of a host-pathogen interaction
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Data from: Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions
All diseases are characterized by distinct changes in tissue molecular distribution. Molecular analysis of intact tissues traditionally requires pre-existing knowledge of, and reagents for, the targets of interest. Conversely, label-free discovery of disease-associated tissue analytes requires destructive processing for downstream identification platforms. Tissue-based analyses therefore sacrifice discovery to gain spatial distribution of known targets, or sacrifice tissue architecture for discovery of unknown targets. To overcome these obstacles, we developed a multi-modality imaging platform for discovery-based molecular histology. We apply this platform to a model of disseminated infection triggered by the important pathogen Staphylococcus aureus, leading to the discovery of infection-associated alterations in the distribution and abundance of proteins and elements in tissue. These data provide an unbiased, three-dimensional analysis of how disease impacts the molecular architecture of complex tissues, enable culture-free diagnosis of infection through imaging-based detection of bacterial and host analytes, and reveal molecular heterogeneity at the host-pathogen interface.
Data from: The effects of the avoidance of infectious hosts on infection risk in an insect-pathogen interaction
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Data from: Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions
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['Evaluating the effect of spaceflight on the host-pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium']
['Spaceflight uniquely alters the physiology of both human cells and microbial pathogens, stimulating cellular and molecular changes directly relevant to infectious disease. However, the influence of this environment on host-pathogen interactions remains poorly understood. Here we report our results from the STL-IMMUNE study flown aboard Space Shuttle mission STS-131, which investigated multi-omic responses (transcriptomic, proteomic) of human intestinal epithelial cells to infection with Salmonella Typhimurium when both host and pathogen were simultaneously exposed to spaceflight. To our knowledge, this was the first in-flight infection and dual RNA-seq analysis using human cells. Additionally, it is the first global transcriptomic and proteomic profiling of human intestinal epithelial cultures during spaceflight (either infected or uninfected).']
A next generation three-dimensional hydrogel-based culture system for studying host-pathogen interaction and drug efficacy in tuberculosis
GEO Series GSE216503. Homo sapiens; Mycobacterium tuberculosis H37Rv. 11 samples. Type: Expression profiling by high throughput sequencing.
Evaluating the effect of spaceflight on the host-pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium
GEO Series GSE156066. Salmonella enterica subsp. enterica serovar Typhimurium; Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Host-pathogen interaction of Atlantic salmon (Salmo salar) and the ectoparasite, Neoparamoeba perurans in amoebic gill disease
GEO Series GSE166760. Paramoeba perurans; Salmo salar. 33 samples. Type: Expression profiling by high throughput sequencing.
Host and pathogen interaction: time course
GEO Series GSE32119. Candida albicans; Danio rerio. 54 samples. Type: Expression profiling by array.
Determination of an Interaction Network between an Extracellular Bacterial Pathogen and the Human Host
GEO Series GSE130901. [Haemophilus] ducreyi; Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Dynamic host-pathogen interactions in pathogen-challenged chicken embryo fibroblasts cells with Marek’s Disease Virus using 3’ end enriched RNA-seq
GEO Series GSE92567. Gallus. 10 samples. Type: Expression profiling by high throughput sequencing.
Host-Pathogen Interactions in the Plasmodium-Infected Mouse Liver at Spatial and Single-Cell Resolution (VISIUM)
GEO Series GSE268068. Plasmodium berghei ANKA; Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Host and pathogen interaction: time course [C. albicans]
GEO Series GSE32117. Candida albicans. 27 samples. Type: Expression profiling by array.
CRISPR-cas cas7 influences the host-pathogen interaction of Porphyromonas gingivalis
GEO Series GSE300980. Porphyromonas gingivalis. 12 samples. Type: Expression profiling by high throughput sequencing.
Global Analysis of the Transcriptional Response of Whitefly to Entomopathogenic Fungi Beauveria bassiana Reveals New Insights on Host-Pathogen Interactions
GEO Series GSE38108. Bemisia tabaci. 3 samples. Type: Expression profiling by high throughput sequencing.
The transcription and translation landscapes during human cytomegalovirus infection reveal novel host-pathogen interactions
GEO Series GSE69906. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing; Other.
Dissecting the immunogenicity of RD1-recombinant live tuberculosis vaccine candidates studying host-pathogen interaction in human primary dendritic cells
GEO Series GSE62423. Homo sapiens. 24 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.