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95 results for “host-pathogen”
Comparative analyses of compatible and incompatible host-pathogen interactions provide insight into divergent host specialization of closely related pathogens
<p><strong><span>Supplementary Animations</span></strong></p> <p><span> </span></p> <p><strong><span>Animation S1. Directed growth of <em>Z. pseudotritici</em> Zp13 hyphae towards wheat stomata 7 dpi. </span></strong><span>Tomographic animation of confocal image z-stack showing spore germination, filament development, and penetration of wheat stomata by hyphae of <em>Z. pseudotritici</em> isolate Zp13 at 7 dpi. Nuclei and wheat cells displayed in <em>purple</em> and fungal structures in <em>green</em>. Scale bar = 50 µm.</span></p> <p><span> </span></p> <p><strong><span>Animation S2. Directed growth of <em>Z. ardabiliae </em>Za17 hyphae towards wheat stomata 17 dpi. </span></strong><span>Tomographic animation of confocal image z-stack showing spore germination, filament development, and penetration of wheat stomata by hyphae of <em>Z. ardabiliae</em><strong> </strong>isolate Za17 at 17 dpi. Nuclei and wheat cells displayed in <em>purple</em> and fungal structures in <em>green</em>. Scale bar = 25 µm.</span></p> <p><span> </span></p> <p><strong><span>Animation S3. <em>Z. pseudotritici</em> Zp13 hyphae penetrate wheat stoma 14 dpi. </span></strong><span>Tomographic animation of confocal image z-stack showing penetration of wheat stoma by two hyphae of <em>Z. pseudotritici</em> isolate Zp13 at 14 dpi. Nuclei and wheat cells displayed in <em>purple</em> and fungal structures in <em>green</em>. Scale bar = 20 µm.</span></p> <p><span> </span></p> <p><strong><span>Animation S4. <em>Z. ardabiliae </em>Za94 hyphae penetrate wheat stoma 8 dpi.</span></strong><span> Tomographic animation of confocal image z-stack showing penetration of wheat stoma by two hyphae of <em>Z. ardabiliae</em> isolate Za94 at 8 dpi. Nuclei and wheat cells displayed in <em>purple</em> and fungal structures in <em>green</em>. Reference transmitted images in <em>grey</em>. Scale bar = 25 µm.</span></p> <p><span> </span></p> <p><strong><span>Animation S5.</span></strong><span> <strong><em>Z. pseudotritici </em>Zp72<em> </em>hypha arrested between guard cells 10 dpi. </strong>Tomographic animation of confocal image z-stack showing infecting hypha of <em>Z. pseudotritici</em> isolate Zp72 that is arrested at wheat stomatal guard cells at 10 dpi. Nuclei and wheat cells displayed in <em>purple</em> and fungal structures in <em>green</em>. Reference transmitted images in <em>grey</em>. Scale bar = 25 µm.</span></p> <p><span> </span></p> <p><strong><span>Animation S6. <em>Z. ardabiliae </em>Za94<em> </em>hyphae arrested between guard cells 17 dpi. </span></strong><span>Tomographic animation of confocal image z-stack showing infecting hyphae of <em>Z. ardabiliae</em> isolate Za94 that are arrested between wheat stomatal guard cells at 17 dpi. Nuclei and wheat cells displayed in <em>purple</em> and fungal structures in <em>green</em>. Scale bar = 25 µm.</span></p> <p><span> </span></p> <p><strong><span>Animation S7. <em>Z. ardabiliae </em>Za48<em> </em>hypha arrested in sub-stomatal cavity 8 dpi. </span></strong><span>Tomographic animation of confocal image z-stack showing infecting hypha of <em>Z. ardabiliae</em> isolate Za48 that is arrested in a wheat sub-stomatal cavity at 8 dpi. Nuclei and wheat cells displayed in <em>purple</em> and fungal structures in <em>green</em>. Reference transmitted images in <em>grey</em>. Scale bar = 25 µm.</span></p> <p><span> </span></p> <p><strong><span>Animation S8. <em>Z. pseudotritici </em>Zp13<em> </em>hypha arrested in sub-stomatal cavity 17 dpi. </span></strong><span>Tomographic animation of confocal image z-stack showing infecting hypha of <em>Z. pseudotritici</em> isolate Zp13 that is arrested in a wheat sub-stomatal cavity at 17 dpi. Nuclei and wheat cells displayed in <em>purple</em> and fungal structures in <em>green</em>. Scale bar = 25 µm.</span></p>
Data and Scripts for "Timing matters in Macrophage / CD4+ T cell interactions: An agent-based model comparing Mycobacterium tuberculosis host-pathogen interactions between latently infected and naïve individuals"
<p>This contains the data and graphing scripts necessary to recreate all figures in the paper "Timing matters in Macrophage / CD4+ T cell interactions: An agent-based model comparing Mycobacterium tuberculosis host-pathogen interactions between latently infected and naïve individuals". Supplemental Material for the paper is also provided here. Please refer to the README.md for instructions on how to use. The model can be found at: https://github.itap.purdue.edu/ElsjePienaarGroup/LTBINaiveinvitroModel/ along with the uncalibrated parameter files and scripts to run on HPCs.</p>
Supplementary material 6 from: Rusch JC, Strand DA, Laurendz C, Andersen T, Johnsen SI, Edsman L, Vrålstad T (2022) Exploring the eDNA dynamics of the host-pathogen pair Pacifastacus leniusculus (Decapoda) and Aphanomyces astaci (Saprolegniales) under experimental conditions. NeoBiota 79: 1-29. https://doi.org/10.3897/neobiota.79.82793
Agent levels of Aphanomyces astaci in individuals of Pacifastacus leniusculus used in the experiment
Pleiotropy promotes the evolution of inducible immune responses in a model of host-pathogen coevolution
<p>The archives uploaded here include the code used to perform the evolutionary simulations as described in <em>Pleiotropy promotes the evolution of inducible immune responses in a model of host-pathogen coevolution </em>authors: Martin,R. Tate, A. as well as the data that was used in the generation of the figures for that paper. Code requires the Julia programming language and necessary packages to run.</p>
Prospective Study to Characterize Host-pathogen Related Factors in Hospitalized and ED Patients With LRTI and/or Sepsis
ClinicalTrials.gov study NCT02025699. IPD Sharing: NO. Countries: 1. Publications: 1.
Host-pathogen Interactions, Immune Response, and Clinical Prognosis at COVID-19 - the CoVUm Trial
ClinicalTrials.gov study NCT04368013. IPD Sharing: NO. Countries: 1. Publications: 6.
Data from: Genetic variation in resistance and fecundity tolerance in a natural host-pathogen interaction
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Data from: Effects of pesticide mixtures on host-pathogen dynamics of the amphibian chytrid fungus
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Experimental evidence that host species composition alters host-pathogen dynamics in a ranavirus-amphibian assemblage
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Data from: Environmentally dependent host-pathogen and vector-pathogen interactions in the barley yellow dwarf virus pathosystem
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Data from: Thermal variability and plasticity drive the outcome of a host-pathogen interaction
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Data from: Immunogenetic novelty confers a selective advantage in host-pathogen coevolution
The major histocompatibility complex (MHC) is crucial to the adaptive immune response of vertebrates and is among the most polymorphic gene families known. Its high diversity is usually attributed to selection imposed by fast-evolving pathogens. Pathogens are thought to evolve to escape recognition by common immune alleles, and, hence, novel MHC alleles, introduced through mutation, recombination, or gene flow, are predicted to give hosts superior resistance. Although this theoretical prediction underpins host–pathogen "Red Queen" coevolution, it has not been demonstrated in the context of natural MHC diversity. Here, we experimentally tested whether novel MHC variants (both alleles and functional "supertypes") increased resistance of guppies (Poecilia reticulata) to a common ectoparasite (Gyrodactylus turnbulli). We used exposure-controlled infection trials with wild-sourced parasites, and Gyrodactylus-naïve host fish that were F2 descendants of crossed wild populations. Hosts carrying MHC variants (alleles or supertypes) that were new to a given parasite population experienced a 35–37% reduction in infection intensity, but the number of MHC variants carried by an individual, analogous to heterozygosity in single-locus systems, was not a significant predictor. Our results provide direct evidence of novel MHC variant advantage, confirming a fundamental mechanism underpinning the exceptional polymorphism of this gene family and highlighting the role of immunogenetic novelty in host–pathogen coevolution.
Data from: Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions
All diseases are characterized by distinct changes in tissue molecular distribution. Molecular analysis of intact tissues traditionally requires pre-existing knowledge of, and reagents for, the targets of interest. Conversely, label-free discovery of disease-associated tissue analytes requires destructive processing for downstream identification platforms. Tissue-based analyses therefore sacrifice discovery to gain spatial distribution of known targets, or sacrifice tissue architecture for discovery of unknown targets. To overcome these obstacles, we developed a multi-modality imaging platform for discovery-based molecular histology. We apply this platform to a model of disseminated infection triggered by the important pathogen Staphylococcus aureus, leading to the discovery of infection-associated alterations in the distribution and abundance of proteins and elements in tissue. These data provide an unbiased, three-dimensional analysis of how disease impacts the molecular architecture of complex tissues, enable culture-free diagnosis of infection through imaging-based detection of bacterial and host analytes, and reveal molecular heterogeneity at the host-pathogen interface.
Supplementary material 4 from: Rusch JC, Strand DA, Laurendz C, Andersen T, Johnsen SI, Edsman L, Vrålstad T (2022) Exploring the eDNA dynamics of the host-pathogen pair Pacifastacus leniusculus (Decapoda) and Aphanomyces astaci (Saprolegniales) under experimental conditions. NeoBiota 79: 1-29. https://doi.org/10.3897/neobiota.79.82793
R-script of MCOCC occupancy analysis
Supplementary material 3 from: Rusch JC, Strand DA, Laurendz C, Andersen T, Johnsen SI, Edsman L, Vrålstad T (2022) Exploring the eDNA dynamics of the host-pathogen pair Pacifastacus leniusculus (Decapoda) and Aphanomyces astaci (Saprolegniales) under experimental conditions. NeoBiota 79: 1-29. https://doi.org/10.3897/neobiota.79.82793
R-Script of GLM analysis
Supplementary material 2 from: Rusch JC, Strand DA, Laurendz C, Andersen T, Johnsen SI, Edsman L, Vrålstad T (2022) Exploring the eDNA dynamics of the host-pathogen pair Pacifastacus leniusculus (Decapoda) and Aphanomyces astaci (Saprolegniales) under experimental conditions. NeoBiota 79: 1-29. https://doi.org/10.3897/neobiota.79.82793
ddPCR and qPCR data from the mesocosm experiments
Supplementary material 1 from: Rusch JC, Strand DA, Laurendz C, Andersen T, Johnsen SI, Edsman L, Vrålstad T (2022) Exploring the eDNA dynamics of the host-pathogen pair Pacifastacus leniusculus (Decapoda) and Aphanomyces astaci (Saprolegniales) under experimental conditions. NeoBiota 79: 1-29. https://doi.org/10.3897/neobiota.79.82793
Primers and probes used in the present study
Supplementary material 5 from: Rusch JC, Strand DA, Laurendz C, Andersen T, Johnsen SI, Edsman L, Vrålstad T (2022) Exploring the eDNA dynamics of the host-pathogen pair Pacifastacus leniusculus (Decapoda) and Aphanomyces astaci (Saprolegniales) under experimental conditions. NeoBiota 79: 1-29. https://doi.org/10.3897/neobiota.79.82793
Results of the GLMM model
Data from: Host-pathogen metapopulation dynamics suggest high elevation refugia for boreal toads
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Data from: Immunogenetic novelty confers a selective advantage in host-pathogen coevolution
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.