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113 results for “hsp90”
A Double-blind Placebo-controlled Randomized Trial Evaluating the Efficacy and Safety of a Novel HSP90 Inhibitor (RGRN-305) in the Treatment of Moderate to Severe Hidradenitis Supppurativa.
ClinicalTrials.gov study NCT05286567. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Data from: HSP90 as a global genetic modifier for male genital morphology in Drosophila melanogaster
The molecular chaperone protein HSP90 has been proposed to modulate genotype-phenotype relationship in a broad range of organisms. To understand the genetic modifier effect of HSP90, genetic variations under the influence of HSP90 need to be identified on a genome-wide scale. Here, we show that HSP90 functions as a genetic modifier of genital morphology in Drosophila melanogaster. We identified a large number of single-nucleotide polymorphisms (SNPs) with an HSP90-dependent effect by using genome wide association analysis. We classified the SNPs into the ones under capacitance effect (smaller allelic effect under HSP90 inhibition) or the ones under potentiation effect (larger allelic effect under HSP90 inhibition). Although the majority of SNPs are under capacitance, there are a large number of SNPs under potentiation. This observation provides support for a model in which Hsp90 is not described exclusively as a 'genetic capacitor', but is described more broadly as a 'genetic modifier'. Because the majority of the candidate genes estimated from SNPs with an HSP90-dependent effect in the current study have never been reported to interact with HSP90 directly, the global genetic modifier effect of HSP90 may be exhibited through epistatic interactions in gene regulatory networks.
Raw plasmon ruler data of conformational dynamics of Hsp90
<p>Four time series from Plasmon ruler experiments<br>time resolution 0.1 s.<br>total length 6 h<br>Hsp90 concentration 240 pM<br>First analyzed and published 2018 in: https://pubs.acs.org/doi/10.1021/acs.nanolett.8b03342</p> <p>2024 analyzed for memory in conformational dynamics in: https://arxiv.org/abs/2404.16799</p>
Fig. 5 in Molecular cloning of heat shock protein gene HSP90 and effects of abamectin and double-stranded RNA on its expression in Panonychus citri (Trombidiformes: Tetranychidae)
Fig. 5. Relative expressional levels of HSP90 mRNA in P. citri adult females afer treatment at 32 °C with abamectin concentrations of LC25, LC50 and LC75 for the indicated times. Data are shown as means of 3 replicates ± SD. The relative expression level of HSP90 mRNA in the control group is equal to 1.0 and is marked with a dashed line. The asterisk above the bar indicates a significance difference between treatment with abamectin and control group (t-test, P <0.05).
Fig. 3 in Molecular cloning of heat shock protein gene HSP90 and effects of abamectin and double-stranded RNA on its expression in Panonychus citri (Trombidiformes: Tetranychidae)
Fig. 3. Relative expressional levels of HSP90 mRNA in P. citri adult females afer treatment with abamectin at LC25, LC50 and LC75levels for the indicated times at 18 °C.Data are shown as means of 3 replicates ± SD. The relative expression level of HSP90 mRNA in the control group is equal to 1.0 and is marked with a dashed line. The asterisk above the bar indicates a significance difference between treatment with abamectin and control group (t-test, P <0.05).
Fig. 1 in Molecular cloning of heat shock protein gene HSP90 and effects of abamectin and double-stranded RNA on its expression in Panonychus citri (Trombidiformes: Tetranychidae)
Fig. 1. The cDNA and deduced amino acid sequence of HSP90 of Panonychus citri adult females. The start and stop codons are boxed; the numbers on the lef are for the positions of nucleotides and amino acids in the sequences.
Fig. 7 in Molecular cloning of heat shock protein gene HSP90 and effects of abamectin and double-stranded RNA on its expression in Panonychus citri (Trombidiformes: Tetranychidae)
Fig. 7. Relative expressional levels of HSP90 mRNA in adult female P. citri Mc- Gregor afer treatment with dsRNA at concentrations equivalent to 0.1 µg/µL, 0.2 µg/µL and 0.4 µg/µL. Data are shown as means of 3 replicates ± SD. The relative expression level of HSP90 mRNA in the control group is equal to 1.0 and is marked with a dashed line. The asterisk above the bar indicates a significance difference between treatment with dsRNA and control group (t-test, P <0.05).
Fig. 4 in Molecular cloning of heat shock protein gene HSP90 and effects of abamectin and double-stranded RNA on its expression in Panonychus citri (Trombidiformes: Tetranychidae)
Fig. 4. Relative expressional levels of HSP90 mRNA in P. citri adult females afer treatment at 25 °C with abamectin concentrations of LC25, LC50 and LC75 for the indicated times. Data are shown as means of 3 replicates ± SD. The relative expression level of HSP90 mRNA in the control group is equal to 1.0 and is marked with a dashed line. The asterisk above the bar indicates a significance difference between treatment with abamectin and control group (t-test, P <0.05).
Fig. 6 in Molecular cloning of heat shock protein gene HSP90 and effects of abamectin and double-stranded RNA on its expression in Panonychus citri (Trombidiformes: Tetranychidae)
Fig. 6. Relative expressional levels of HSP90 mRNA in P. citri adult females subjected to 18 °C or 32 °C for the length of time indicated. Data are shown as means of 3 replicates ± SD. The relative expression level of HSP90 mRNA in the control group is equal to 1.0 and is marked with a dashed line. The asterisk above the bar indicates a significance difference between treatment with temperature and control group (t-test, P <0.05).
Fig. 1 in Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators
Fig. 1. Structures of compounds 1–21.
HSP90 Inhibitor, AUY922, in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV MF), Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF), and Refractory PV/E
ClinicalTrials.gov study NCT01668173. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of the HSP90 Inhibitor AUY922
ClinicalTrials.gov study NCT01485536. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of the Hsp90 Inhibitor AUY922 Plus Capecitabine for the Treatment of Patients With Advanced Solid Tumors
ClinicalTrials.gov study NCT01226732. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Hsp90 Inhibitor AUY922 for the Treatment of Patients With Refractory Gastrointestinal Stromal Tumor
ClinicalTrials.gov study NCT01404650. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Hsp90 Inhibitor, STA-9090 for Relapsed or Refractory Small Cell Lung Cancer
ClinicalTrials.gov study NCT01173523. IPD Sharing: NO. Countries: 1. Publications: 0.
Hsp90 Inhibitor STA-9090 in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Previously Treated With Docetaxel-Based Chemotherapy
ClinicalTrials.gov study NCT01270880. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: HSP90 as a global genetic modifier for male genital morphology in Drosophila melanogaster
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Data from: Downregulation of the evolutionary capacitor Hsp90 is mediated by social cues
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The protective role of the HSP90 inhibitor, STA-9090, in lungs of SARS-CoV-2-infected Syrian golden hamsters
GEO Series GSE227846. Mesocricetus auratus; Homo sapiens. 56 samples. Type: Expression profiling by high throughput sequencing.
Highly selective HSP90 inhibitor, pimitespib, demonstrates its potent growth suppressive activity to adult T-cell leukemia in preclinical models (Su9T01).
GEO Series GSE168558. Homo sapiens. 6 samples. Type: Expression profiling by array.
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