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519 results for “hydrogels”
Palmitic Acid Sophorolipid Biosurfactant: From Self-Assembled Fibrillar Network (SAFiN) To Hydrogels with Fast Recovery
<p>Data are zipped using Winrar 5.40 version</p> <p>Folder "Figures": it contains the images of Figure 1 through 6. Images are available as datasets readable with Origin software (any version) or QTplot software.</p> <p>Folder "Figure 4": it contains images corresponding to Figure 4 and Figure S5. Images can be read nd processed with Fiji software. Folder also contains ascii files corresponding to the plots.</p> <p>File "Figures": this is the powerpoint file containing all composed images of the main text and Supporting Information. Plots can be opened with Origin software.</p> <p> </p>
Data regarding "Development and evaluation of RADA-PDGF2 self-assembling peptide hydrogel for enhanced skin wound healing"
<p>Raw data for data published in Development and evaluation of RADA-PDGF2 self-assembling peptide hydrogel for enhanced skin wound healing, Front. Pharmacol. Sec. Experimental Pharmacology and Drug Discovery Volume 14 - 2023 | <a href="https://doi.org/10.3389/fphar.2023.1293647">doi: 10.3389/fphar.2023.1293647</a></p>
Seamless integration of conducting hydrogels in daily life: from preparation to wearable application
<p><span>The dataset contains the recent advances in the development of CHs for smart wearable devices. We summarize the synthesis of conducting polymers and the various approaches used to prepare CHs. We also analyze their </span><span>properties </span><span>and discuss the fabrication of specific geometries to improve the performance of the final CH-based wearable device</span><span>s.</span><span>. The studies presented herein contribute to the growing field of wearable devices by highlighting the potential of CHs as versatile and functional material platform</span><span>s. The development and integration of CHs present challenges and opportunities that highlight the need for novel fabrication techniques and advanced materials.</span></p>
SEM photographs of agarose hydrogels
<p>SEM photographs of agarose hydrogels studied in the paper "Synthesis and Characterization of Agarose Hydrogels for Release of Diclofenac Sodium" published in Materials 16(17) (2023) 6042. doi: 10.3390/ma16176042.</p>
Comparing natural hydrogels to self-assembling peptides in spinal cord injury treatment: a systematic review
<p><strong>Abstract</strong></p> <p><em><strong>Background:</strong></em><em> </em>In many cases, central nervous system (CNS) injury is unchanging due to the absence of neuronal regeneration and repair capabilities.<strong> </strong>In recent years, regenerative medicine, and especially hydrogels, have reached a significant amount of attention for their promising results for the treatment of spinal cord injury (SCI) currently considered permanent. Hydrogels are categorized based on their foundation: synthetic, natural, and combination. The objective of this study was to compare the properties and efficacy of commonly used hydrogels, like collagen, and other natural peptides with synthetic self-assembling peptide hydrogels in the treatment of SCI. </p> <p><em><strong>Methods</strong></em><em>:</em><em> </em>Articles were searched in PubMed, Scopus, Web of Science, and Embase. All studies from 1985 until January 2020 were included in the primary search. Eligible articles were included based on the following criteria: administering hydrogels (both natural and synthetic) for SCI treatment, soley foucsing on spinal cord injury treatment, and published in a peer-reviewd journal. Data surronding xonal regeneration, revascularization, elasticity, drug delivery efficacy, and porosity were extracted.</p> <p><em><strong>Results:</strong></em> A total of 24 articles were included for full-text review and data extraction. There were only one experimental study directly comparing Collagen I (as natural hydorgel) and PEG (as synthetic hydrogels) in an <em>in vitro </em>setting. The included study suggested PEG’s cell behavior is more expectable in the injury site, which makes it a more reliable scaffold.</p> <p><em><strong>Conclusions:</strong></em> There is limited research comparing and evaluating both types of natural and self-assembling peptides (SAPs) in the same animal or <em>in vitro</em> study, despite its importance. Although we assume that the remodeling of natural scaffolds may lead to a stable hydrogel, there was not a definitive conclusion that synthetic hydrogels are more beneficial than natural hydrogels in neuronal regeneration.</p>
Dataset for Engineering multifunctional dynamic hydrogel for biomedical and tissue regenerative applications
<p><span>Hydrogels have emerged in various biomedical applications, including tissue engineering and medical devices, due to their ability to imitate the natural extracellular matrix (ECM) of tissues. However, conventional static hydrogels lack the ability to dynamically respond to changes in their surroundings to withstand the robust changes of the biophysical microenvironment and to trigger on-demand functionality such as drug release and mechanical change. In contrast, multifunctional dynamic hydrogels can adapt and respond to external stimuli and have drawn great attention in recent studies. It is realized that the integration of nanomaterials into dynamic hydrogels provides numerous functionalities for a great variety of biomedical applications that cannot be achieved by conventional hydrogels. This review article provides a comprehensive overview of recent advances in designing and fabricating dynamic hydrogels for biomedical applications. We describe different types of dynamic hydrogels based on breakable and reversible covalent bonds as well as noncovalent interactions. These mechanisms are described in detail as a useful reference for designing crosslinking strategies that strongly influence the mechanical properties of the hydrogels. We also discuss the use of dynamic hydrogels and their potential benefits. This review further explores different biomedical applications of dynamic nanocomposite hydrogels, including their use in drug delivery, tissue engineering, bioadhesives, wound healing, cancer treatment, and mechanistic study, as well as multiple-scale biomedical applications. Finally, we discuss the challenges and future perspectives of dynamic hydrogels in the field of biomedical engineering, including the integration of diverse technologies.</span></p>
CXCL12-loaded-hydrogel (CLG): a new device for metastatic Circulating Tumor Cells (CTCs) capturing and characterization
<p><strong>Background</strong>: Circulating Tumor Cells (CTCs) represent a small, heterogeneous population that comprise the minority of cells able to develop metastasis. To trap and characterize CTCs with metastatic attitude, a CXCL12-loaded hyaluronic-gel (CLG) was developed. CXCR4+cells with invasive capability would infiltrate CLG.<br><strong>Methods</strong>: Human colon, renal, lung and ovarian cancer cells (HT29, A498, H460 and OVCAR8 respectively) were seeded on 150 µl Empty Gels (EG) or 300 ng/ml CXCL12 loaded gel (CLG) and allowed to infiltrate for 16 hours. Gels were then digested and fixed with 2% FA-HAse for human cancer cell enumeration or digested with HAse and cancer cells recovered. CLG-recovered cells migrated toward CXCL12 and were tested for colonies/spheres formation. Moreover, CXCR4, E-Cadherin and Vimentin expression was assessed through flow cytometry and RT-PCR. The clinical trial “TRAP4MET” recruited 48 metastatic/advanced cancer patients (8 OC, 8 LC, 8 GBM, 8 EC, 8 RCC and 8 EC). 10 cc whole blood were devoted to PBMCs extraction (7cc) and ScreenCell™ filters (3cc) CTCs evaluation. Ficoll-isolated patient’s PBMCs were seeded over CLG and allowed to infiltrate for 16 hours; gels were digested and fixed with 2% FA-HAse, cells stained and DAPI+/CD45-/pan-CK+ cells enumerated as CTCs.<br><strong>Results</strong>: Human cancer cells infiltrate CLG more efficiently than EG (CLG/EG ratio 1.25 for HT29/ 1.58 for A498/ 1.71 for H460 and 2.83 for OVCAR8). CLG- recovered HT29 cells display hybrid-mesenchymal features [low E-cadherin (40%) and high vimentin (235%) as compared to HT29], CXCR4 two-fold higher than HT29, efficiently migrate toward CXCL12 (two-fold higher than HT29) and developed higher number of colonies (171±21 for HT29-CLG vs 131±8 colonies for HT29) /larger spheres (spheroid area: 26561±6142 µm2 for HT29-CLG vs 20297±7238 for HT29). In TRAP4MET clinical trial, CLG-CTCs were isolated in 8/8 patients with OC, 6/8 with LC, 6/8 with CRC, 8/8 with EC, 8/8 with RCC cancer and 5/8 with GBM. Interestingly, in OC, LC and GBM, CLG isolated higher number of CTCs as compared to the conventional ScreenCell™ (CLG/SC ratio=1.88 for OC, 2.47 for LC and 11.89 for GBM). Bland and Altman blot analysis and Passing and Bablok regression analysis showed concordance between the methodological approaches but indicate that SC and CLG are not superimposable suggesting that the two systems select cells with different features.<br><strong>Conclusion</strong>: CLG might represent a new and easy tool to isolate invasive CTCs in multiple cancers such as OC, LC and GBM at today orphan of reliable methods to consistently detect CTCs. </p>
Data of Graduation Project 'Anisotropic Swelling of a Cylindrical Hydrogel'
<p>The data is generated as part of the graduation project 'Anisotropic Swelling of a Cylindrical Hydrogel'.</p> <p>The data is generated via Mathematica Notebooks that can be retrieved directly from the GitHub. These notebooks are annotated, and the data provided here can be reproduced by using the appropriate parameters. The Mathematica notebooks can be subdivided in two categories, namely 1) Notebooks that generate data and 2) Notebooks that analyze the data. Notebooks that are used to analyze the data must be adjusted to import the data correctly. ReadMe-files are added to guide you through the process when using these notebooks. </p> <p>The data that is stored here can be subdivided into three different sets:</p> <ol> <li><strong>Data - spring models.zip.</strong> This data is related to the spring model as introduced in part I of the thesis.</li> <li><strong>Data – Spherical Poroelasticity Model.zip.</strong> This data is related to the spherical poroelastic model as introduced in the appendix of the thesis.</li> <li><strong>Data – Cylindrical Poroelasticity Model.zip. </strong>This data is related to the cylindrical poroelastic model as introduced in part II of the thesis.</li> </ol> <p>Each of these folders are subdivided into folders, which contain the following data:</p> <ol> <li><strong>Data – spring models.zip. </strong></li> </ol> <p>Read the ReadMe-Information-Data.txt for more information. Each folder contains the data that is generated by the notebook 'discrete3Dmodel-meanB-experimental3kDa.nb'. The numbers indicated the values for Ka, Kb and Kc before and after the transition respectively.</p> <p>Data is used to generate figure 3.3 of the report.</p> <ol> <li><strong>Data – Spherical Poroelasticity Model.zip.</strong></li> </ol> <ul> <li>Typical results for spherical hydrogel. Folder contains the data that is generated by the notebook Spherical-swelling-notebook.wl with the parameters as provided in the folder.</li> </ul> <p>Data is used to generate figure C.2, C.3 of the report</p> <ul> <li>Effect of grid size N - N = 5. Folder contains the data that is generated by the notebook Spherical-swelling-notebook.wl with the parameters as provided in the folder.</li> </ul> <p>Data is used to generate figure C.3 of the report</p> <ul> <li>Effect of chemical potential mu - mu = 0. Folder contains the data that is generated by the notebook Spherical-swelling-notebook.wl with the parameters as provided in the folder.</li> </ul> <p>Data is used to generate figure C.3 of the report</p> <ol> <li><strong>Data – Cylindrical Poroelasticity Model.zip. </strong></li> </ol> <ul> <li>Equilibrium Dynamics. Folder contains data generated by the notebook Cylinder-finalversion-annotated.wl with the parameters as provided in the folder.</li> </ul> <p>Data is used to generate figures 6.1 – 6.4 of the report</p> <ul> <li>Anisotropy parameters. Folder contains data for different anisotropy parameters generated by the notebook Cylinder-finalversion-annotated.wl with the parameters as provided in the folder.</li> </ul> <p>Data is used to generate figures 6.5 – 6.7 of the report</p> <ul> <li>Relative Humidity Rate. Folder contains data for different rates (i.e. different times) and different gridpoints generated by the notebook Cylinder-finalversion-annotated.wl with the parameters as provided in the folder.</li> </ul> <p>Data is used to generate figures 6.8 – 6.10 of the report</p> <ul> <li>Transition. Folder contains data for transitions with different properties generated by the notebook Cylinder-finalversion-annotated.wl with the parameters as provided in the folder.</li> </ul> <p>Data is used to generate figures 6.11 – 6.14, E.1 – E.8 of the report</p> <p>The other figures in the report are generated without explicit data storage, and can (in most cases) be generated directly with the appropriate notebook provided at GitHub.</p> <p>The correct version on GitHub used for generating the data can be found via https://github.com/QBraat/Cylindrical-Gel-Swelling/releases/tag/v1.0.</p>
Raw Research Data Supporting "Generalizing hydrogel microparticles into a new class of bioinks for extrusion bioprinting"
<p>Raw research data supporting:</p> <p>Xin S. et al., 2021, Science Advances, Vol 7, Issue 42, abk3087</p>
3D bioprinted alginate-gelatin hydrogel patches containing cardiac spheroids recover heart function in a mouse model of myocardial infarction
<p>Datasets for Roche et al (2023), '3D bioprinted alginate-gelatin hydrogel patches containing cardiac spheroids recover heart function in a mouse model of myocardial infarction'.</p>
Data from: Sustained neurotrophin-3 delivery from hyaluronic acid hydrogels for neural tissue regeneration
<p>The goal of this work was to design a polymer-based platform capable of localized, long-term delivery of biologically active neurotropic factors using an affinity-based approach. Here, we synthesized hyaluronic acid-methylfuran (HA-mF) hydrogels that provide sustained, affinity-based release of neurotrophin-3 (NT-3), a growth factor that promotes axon growth for 28 days. A Diels-Alder crosslinking reaction between HA-mF and polyethylene glycol (PEG)-dimaleimide occurs within 15 minutes under physiological conditions, resulting in injectable hydrogels that can be polymerized in the presence of cells and growth factors. We also tuned the hydrogel's storage modulus to match that of native rat spinal cord tissue, providing a platform not only for localized drug delivery but also a suitable vehicle for cellular transplantation. The NT-3 released from the HAmF hydrogels remains bioactive for at least 14 days, promoting axonal growth from primary sensory neurons as well as stem cell-derived V2a interneurons and motoneurons <em>in vitro</em>. The hydrogels also supported cell growth allowing for 3-dimensional axonal extensions within the scaffold matrix. Here we confirm the protective role of HA-mF on matrix-bound NT-3 activity and show that these hydrogels are an excellent platform for drug delivery for neural applications.</p>
Methacrylated Gellan gum hydrogel: a smart tool to face complex problems in the cleaning of paper materials
<p>Data presented in the article entitled <strong>Methacrylated Gellan gum hydrogel: a smart tool to face complex problems in the cleaning of paper materials</strong></p>
Carboxymethyl starch as a reducing and capping agent in the hydrothermal synthesis of selenium nanostructures for use with 3D-printed hydrogel carrier
<p>The hydrothermal method is a cost-effective and eco-friendly route for preparing various nanomaterials. It can utilize a capping agent, such as a polysaccharide, to govern and define the nanoparticle morphology. Elemental selenium nanostructures (spheres and rods) were synthesized and stabilized using a tailor-made carboxymethyl starch (CMS, degree of substitution = 0.3) under hydrothermal conditions. CMS is particularly convenient because it acts simultaneously as the capping and reducing agent, as verified by several analytical techniques, while the reaction relies entirely on green solvents. Furthermore, the effect of sodium selenite concentration, reaction time, and temperature on the nanoparticle size, morphology, microstructure, and chemical composition was investigated to identify the ideal synthesis conditions. A pilot experiment demonstrated the feasibility of implementing the synthesized nanoparticles into vat photopolymerization 3D-printed hydrogel carriers based on 2-hydroxyethyl methacrylate (HEMA). When submersed into the water, the subsequent particle release was confirmed by dynamic light scattering (DLS), promising great potential for use in bio-3D printing and other biomedical applications.</p>
Prostate-Rectal Separation With PEG Hydrogel and Its Effect on Decreasing Rectal Dose
ClinicalTrials.gov study NCT02212548. IPD Sharing: YES. Countries: 1. Publications: 2.
Effect of Autologous Blood Patch Injection Versus BioSentry Hydrogel Tract Plug in the Reduction of Pneumothorax Risk Following Lung Biopsy Procedures
ClinicalTrials.gov study NCT02224924. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Hydrogel Endovascular Aneurysm Treatment Trial
ClinicalTrials.gov study NCT01407952. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Hydrogel Injection to Assist Endoscopic Submucosal Dissection
ClinicalTrials.gov study NCT03321396. IPD Sharing: NO. Countries: 1. Publications: 2.
Longitudinal Evaluation of Silicone Hydrogel (LASH) Study
ClinicalTrials.gov study NCT00727402. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Taclonex Ointment With Hydrogel Patch Occlusion for the Treatment of Psoriasis
ClinicalTrials.gov study NCT00924950. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Carboxymethyl starch as a reducing and capping agent in the hydrothermal synthesis of selenium nanostructures for use with 3D-printed hydrogel carrier
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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