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26 results for “icefish”
Data from: Evidence for past and present hybridization in three Antarctic icefish species provides new perspectives on an evolutionary radiation
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Data from: Evolutionary suppression of erythropoiesis via the modulation of TGF-β signaling in an Antarctic icefish
The Antarctic icefish, a family (Channichthyidae) of teleosts within the perciform suborder Notothenioidei, are the only known vertebrates without oxygen-transporting haemoglobins and that are largely devoid of circulating erythrocytes. To elucidate the evo-devo mechanisms underpinning the suppressed erythropoiesis in the icefish, we conducted comparative studies on the transcriptomes and microRNAomes of the primary haematopoietic tissues between an icefish (Chionodraco hamatus) and two red-blooded notothenioids (Trematomus bernacchii and Gymnodraco acuticeps). We identified substantial remodelling of the haematopoietic programs in the icefish through which erythropoiesis is selectively suppressed. Experimental verification showed that erythropoietic suppression in the icefish may be attributable to the upregulation of TGF-β signalling, which coincides with reductions in multiple transcription factors essential for erythropoiesis and the upregulation of hundreds of microRNAs, the majority (> 80%) of which potentially target erythropoiesis regulating factors. Of the six microRNAs selected for verification, three miRNAs (miR-152, miR-1388 and miR-16b) demonstrated suppressive functions on GATA1 and ALAS2, which are two factors important for erythroid differentiation, resulting in reduced numbers of erythroids in microinjected zebra fish embryos. Codon substitution analyses of the genes of the TGF-β superfamily revealed signs of positive selection in TGF-β1 and endoglin in the lineages leading to Antarctic notothenioids. Both genes are previously known to function in erythropoietic suppression. These findings implied a general trend of erythropoietic suppression in the cold-adapted notothenioid lineages through evolutionary modulation of the multi-functional TGF-β signalling pathway. This trend is more pronounced in the haemoglobin-less icefish, which may pre-emptively hinder the otherwise defective erythroids from production.
Figure 2. – Lepidonotothen squamifrons. A in Some histological data on bone and teeth in the grey notothen (Lepidonotothen squamifrons) and in the mackerel icefish (Champsocephalus gunnari) (Notothenioidei; Perciformes; Teleostei)
Figure 2. – Lepidonotothen squamifrons. A: Cross section of the premaxilla (microradiography). B: Cross section of the dental (microradiography). C: Cross section of a dorsal spiny ray (microradiography). D: Cross section of a caudal vertebra (microradiography) showing the numerous vertebral bony arches fixed on the centrum. E: Detail of a section of a caudal vertebra (Polarized light showing the fibrous organization of bone and two vascular canals (arrowheads). F: Same section than Fig. E observed in transmitted natural light. The vascular canals are surround- ed by a reversal line (arrows). G: Detail of a section (polarized light) in a vertebral centrum showing growth marks. Scale bars: A = 500 μm; B = 250 μm; C, D, E, F = 200 μm; G = 50 μm. A: 415 mm TL; B-D, G: 333 mm TL; E, F: 250 mm TL.
Figure 3. – Lepidonotothen squamifrons. A in Some histological data on bone and teeth in the grey notothen (Lepidonotothen squamifrons) and in the mackerel icefish (Champsocephalus gunnari) (Notothenioidei; Perciformes; Teleostei)
Figure 3. – Lepidonotothen squamifrons. A: Horizontal section (microradiography) showing several cross sections of teeth on the right and the lower jaw on the left. B: Horizontal section (microradiography) taken lower than Fig. A. The wall of the pulp cavity of the central tooth (*) is crossed by vascular canals. We can see three very young non-functional teeth (arrowheads). C: Cross section of the lower jaw (microradiography) showing a young erupted tooth (arrow) and a fall- en tooth (*). D: Detail of a functional tooth showing the unmineralized ligament (arrowhead). E: Cross section of the jaw showing a tooth bud inserted in an alveola (arrow), beside a functional tooth (arrowhead). F, G: Cross section of a tooth (respectively in transmitted natural and polarized light. The more lateral dentinous tissue is striated, indi- cating the presence of odontoblastic canaliculi. (Scale bars: A, D = 250 μm; B, F, G = 150 μm; C = 500 μm; E = 1 mm. (A, B, F, G: 259 mm TL; C: 415 mm TL; D, E: 190 mm TL).
Data from: Evolutionary suppression of erythropoiesis via the modulation of TGF-β signaling in an Antarctic icefish
Open the record for dataset details and reuse information.
Evolutionary suppression of erythropoiesis via the modulation of TGF-β signaling in an Antarctic icefish
GEO Series GSE70113. Gymnodraco acuticeps; Trematomus bernacchii; Chionodraco hamatus. 9 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
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OpenNeuro
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