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573 results for “immune function”
Impaired immune function accompanies social evolution in spiders
<p><span>An efficient immune system is essential to the survival of many animals. Sociality increases risk of pathogen transmission, which should select for enhanced immune function. However, two hypotheses instead predict a weakened immune function: relaxed selection caused by social immunity/protection, and reduced efficacy of selection due to inbreeding, reproductive skew, and female bias in social species that reduces effective population size and accelerate genetic drift. We assessed the effect of social evolution on immune function in a comparative study of two social spider species and their closely related subsocial sister species (genus <em>Stegodyphus</em>). The haemolymph of social species was less efficient in inhibiting the growth of potentially pathogenic bacteria than that of subsocial species. Reduced efficacy of selection in social species was supported by comparative genomic analysis of immune genes showing substantially elevated non-synonymous substitutions in one of the social species. We propose that this impaired immune function is likely to be a result of reduced efficacy of selection because the evolution of sociality in spiders is accompanied by demographic processes that elevate genetic drift. There may also be positive feedback between pathogen-induced local extinctions and the resulting elevation of genetic drift which further weakens responses to selection by pathogens.</span></p>
Immune Landscape and Gene Function Analysis of Uveal Melanoma Based on Focal Adhesion-Related Gene Typing
<p><strong>Figure legend</strong><strong>s</strong></p> <p><strong>Figure 1 Identification of focal adhesion gene clusters and immune analysis</strong></p> <p>(A) Relative changes in the area under the CDF curve. (B) Consensus clustering results, K=3. (C) Survival curves of different clusters. (D) ssGSEA heatmap showing differences in immune infiltration between clusters. (E) Expression levels of immune checkpoints in different clusters. (F) Violin plots of immune scores, stromal scores, ESTIMATE scores, and tumor purity scores.</p> <p> </p> <p><strong>Figure 2 GSEA pathway enrichment analysis</strong></p> <p> </p> <p><strong>Figure 3 PPI network related to DEGs between cluster 2 and clusters 1 and 3 and HUB gene selection</strong></p> <p>(A) Selection of DEGs between cluster 2 and clusters 1 and 3. (B) PPI network of DEGs between clusters. (C) Intersection analysis of the top 20 HUB genes in the PPI network using five algorithms.</p> <p> </p> <p><strong>Figure 4 Functional analysis of HUB genes in the interaction network and construction of co-expression network</strong></p> <p>(A) Heatmap showing the expression of HUB genes in cluster 2 and clusters 1 and 3. (B) GO functional enrichment analysis of HUB genes. (C) KEGG pathway enrichment analysis of HUB genes. (D) Construction of the co-expression network of HUB genes and their co-expressed genes.</p> <p> </p> <p><strong>Figure 5 Survival curves of patients corresponding to HUB genes at high and low expression levels</strong></p> <p> </p> <p><strong>Figure 6 Exploration of the correlation between HUB genes and drug sensitivity through CellMiner database</strong></p> <p> </p>
The N-terminal executioner domains of NLR immune receptors are structurally and functionally conserved across major plant lineages: Extended Data
<p>Raw data and supporting files for an updated version of the manuscript now entitled "The N-terminal executioner domains of NLR immune receptors are structurally and functionally conserved across major plant lineages".</p> <p>Related to an original version of the bioRxiv preprint: https://www.biorxiv.org/content/10.1101/2022.10.19.512840v1 </p>
Comparing Immune System Suppression to Medication for Unexplained Heart Function and Irregular Heartbeat
ClinicalTrials.gov study NCT06635863. IPD Sharing: YES. Countries: 1. Publications: 18.
Selenium and Immune Function
ClinicalTrials.gov study NCT00279812. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Almonds: Digestive Health and Immune Function of Adults and Children
ClinicalTrials.gov study NCT01973595. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Immune Function and Muscle Adaptations to Resistance Exercise in Older Adults
ClinicalTrials.gov study NCT02261961. IPD Sharing: NO. Countries: 1. Publications: 4.
Immune Intervention With Rituximab to Preserve Beta Cell Function in Early Onset Type 1 Diabetes
ClinicalTrials.gov study NCT01280682. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Fish Oil (Omega 3), Immune Function, and Mood
ClinicalTrials.gov study NCT00385723. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Pilot Study of Leuprolide to Improve Immune Function After Allogeneic Bone Marrow Transplantation
ClinicalTrials.gov study NCT01338987. IPD Sharing: NO. Countries: 1. Publications: 5.
Electro-acupuncture at Zusanli, Qihai, and Guanyuan Acupoints Regulate Immune Function in Patients With Sepsis
ClinicalTrials.gov study NCT05367986. IPD Sharing: YES. Countries: 1. Publications: 5.
Yoga, Immune Function, and Health
ClinicalTrials.gov study NCT00371397. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dipeptidyl Peptidase-4 Inhibition and Immune Function in HIV
ClinicalTrials.gov study NCT01093651. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Lifestyle Intervention in Patients With Chronic Kidney Disease on Fitness and Immune Function
ClinicalTrials.gov study NCT05649657. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Flexibility of fetal tolerance: Immune function during pregnancy varies between ecologically distinct populations
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A common measure of prey immune function is not constrained by the cascading effects of predators
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Genetic and functional analysis of Raynaud’s syndrome implicates loci in vasculature and immunity
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Impaired immune function accompanies social evolution in spiders
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Data from: Fitness outcomes in relation to individual variation in constitutive innate immune function
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Data for: Innate immune function and antioxidant capacity of nestlings of an African raptor co-vary with the level of urbanization around breeding territories
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.