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ShareScore release 0.9.0
Dataset results
54 results for “immunogenetics”
Data from: Immunogenetic heterogeneity in a widespread ungulate: the European roe deer (Capreolus capreolus)
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Data from: Selection from parasites favors immunogenetic diversity but not divergence among locally adapted host populations
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Data from: Linking innate immunogenetic variation with phenotypic traits in a wild population of tree swallows, Tachycineta bicolor
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Data from: Lack of spatial immunogenetic structure among wolverine (Gulo gulo) populations suggestive of broad scale balancing selection
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Data from: Immunogenetic response of the bananaquit in the face of malarial parasites
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Data from: Development of a genotype-by-sequencing immunogenetic assay as exemplified by screening for variation in red fox with and without endemic rabies exposure
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Data from: Prelude to a panzootic: gene flow and immunogenetic variation in northern little brown myotis vulnerable to bat white-nose syndrome
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Data from: Host-parasite network structure is associated with community-level immunogenetic diversity
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Annotated transcriptome data from: Transcriptome annotation reveals minimal immunogenetic diversity among Wyoming toads, Anaxyrus baxteri
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Data from: Small-scale intraspecific patterns of adaptive immunogenetic polymorphisms and neutral variation in Lake Superior lake trout
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Data from: Spatial patterns of immunogenetic and neutral variation underscore the conservation value of small, isolated American badger populations
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Data from: Transcriptomic characterization of the immunogenetic repertoires of heteromyid rodents
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Data from: Weak link between dispersal and parasite community differentiation or immunogenetic divergence in two sympatric cichlid fishes
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Data from: Immunogenetic novelty confers a selective advantage in host-pathogen coevolution
The major histocompatibility complex (MHC) is crucial to the adaptive immune response of vertebrates and is among the most polymorphic gene families known. Its high diversity is usually attributed to selection imposed by fast-evolving pathogens. Pathogens are thought to evolve to escape recognition by common immune alleles, and, hence, novel MHC alleles, introduced through mutation, recombination, or gene flow, are predicted to give hosts superior resistance. Although this theoretical prediction underpins host–pathogen "Red Queen" coevolution, it has not been demonstrated in the context of natural MHC diversity. Here, we experimentally tested whether novel MHC variants (both alleles and functional "supertypes") increased resistance of guppies (Poecilia reticulata) to a common ectoparasite (Gyrodactylus turnbulli). We used exposure-controlled infection trials with wild-sourced parasites, and Gyrodactylus-naïve host fish that were F2 descendants of crossed wild populations. Hosts carrying MHC variants (alleles or supertypes) that were new to a given parasite population experienced a 35–37% reduction in infection intensity, but the number of MHC variants carried by an individual, analogous to heterozygosity in single-locus systems, was not a significant predictor. Our results provide direct evidence of novel MHC variant advantage, confirming a fundamental mechanism underpinning the exceptional polymorphism of this gene family and highlighting the role of immunogenetic novelty in host–pathogen coevolution.
Guselkumab Immunogenetics
ClinicalTrials.gov study NCT04645355. IPD Sharing: YES. Countries: 1. Publications: 0.
Eye and Immunogenetic Features of Sarcoidosis
ClinicalTrials.gov study NCT00379275. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Immunogenetic Profiling of Dupilumab for the Treatment of Atopic Dermatitis
ClinicalTrials.gov study NCT03293030. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Social discrimination by quantitative assessment of immunogenetic similarity
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Data from: Reciprocal translocation of small numbers of inbred individuals rescues immunogenetic diversity
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Data from: Immunogenetic novelty confers a selective advantage in host-pathogen coevolution
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ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.