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895 results for “immunology”
Raw CyTOF images associated with Moldoveanu et al. 2022, Science Immunology
<p>This dataset contains the raw CyTOF images associated with the paper "An In-depth Map of the Melanoma Immune Microenvironment and Correlates of Immunotherapy Response by Imaging Mass Cytometry" (Moldoveanu et al. 2022). The MCD files output by CyTOF IMC were exported to one TIFF per channel per sample. This dataset contains one directory per sample (see Supplementary Table S1 for additional information). Each directory contains 46 TIFF images, which includes the 35 channels used in our study, 1 TIFF of the cell segmentation mask, and 10 TIFFs associated with background or unused channels.</p>
Unveiling the autoreactome: Proteome-wide immunological fingerprints reveal the promise of plasma cell depleting therapy
<p>The prevalence and burden of autoimmune and autoantibody mediated disease continues to rise, yet the etiologies of many of these diseases remain unclear. Despite numerous new targeted immunomodulatory therapies, comprehensive approaches to apply and evaluate the effects of these treatments longitudinally are lacking. Here, we leverage advances in PhIPseq methodology to explore the modulation, or lack thereof, for autoreactive antibodies proteome-wide in both health and disease. We demonstrate that each individual, regardless of disease state, possesses a distinct set of autoreactivities constituting a unique immunological fingerprint, or "autoreactome", that is remarkably stable over years. In addition to uncovering important new biology, the autoreactome can be used to better evaluate the relative effectiveness of various therapies in altering autoantibody repertoires. We find that therapies targeting B-Cell Maturation Antigen (BCMA) profoundly alter an individual's autoreactome, while anti-CD19 and CD-20 therapies have minimal effects, strongly suggesting a rationale for BCMA or other plasma cell targeted therapies in autoantibody mediated diseases.</p>
Figure 3 in Potential histopathological and immunological effects of SARS-CoV-2 on the liver
Figure 3. Immune-mediated liver injury adapted from Spearman et al. (2021).
Figure 4 in Potential histopathological and immunological effects of SARS-CoV-2 on the liver
Figure 4. The major liver histological features adapted from Díaz et al. (2020).
Figure 1 in Potential histopathological and immunological effects of SARS-CoV-2 on the liver
Figure 1. SARS-CoV-2 structure and life cycle adapted from Zhong et al. (2020).
Nature Immunology articles 2022
<p>This dataset contains articles from year 2022 from Nature Immunology with some added keywords for further filtering. </p>
Recognition of conspecific immunological status in a neotropical paper wasp
<p><span>Host immune activation is common under a pathogen invasion. This physiological response can promote changes in body surface compounds, thus providing chemical cues related to health that might be useful to conspecifics. By recognizing the current immunological status of social partners, individuals can modulate their behavior to minimize the risk of infection. Tegument wounding, an immune elicitor, is a required step for many parasites to become established in a host. By using the neotropical eusocial paper wasp <em>Mischocyttarus metathoracicus</em> as a model organism, we first performed a lure presentation experiment in the field to test if wasps discriminate conspecific immunological status (experimentally manipulated by wounding) during on-nest social interactions. Then, we performed gas chromatography-mass spectrometry analyses to test if immunostimulation by wounding alters the wasps' cuticular hydrocarbon profile. We found that wasps reduce the duration of aggressive physical contact when interacting with wounded lures, despite displaying a similar frequency of inspective and aggressive behaviors toward both the wounded and the control lures. Besides, we found a subtle increase in a single cuticular hydrocarbon in the wounded wasps. Thus, wasps recognize conspecific immunological status, likely by chemical cues, and modulate their behavior in order to defend the colony against intruders while minimizing the personal risk of infection.</span></p>
Raw data for manuscript: Use of immunology in news and YouTube videos in the context of COVID-19: politicization and information bubbles
<p>Coding of newsarticles and videos related to immunology and COVID-19 in Italian and English</p>
Prospective Evaluation of Immunological, Molecular-genetic, Image-based and Microbial Analyzes to Characterize Tumor Response and Control in Patients With Inoperable Stage III NSCLC Treated With Chemo
ClinicalTrials.gov study NCT05027165. IPD Sharing: NO. Countries: 1. Publications: 1.
COVID-19 Variant Immunologic Landscape Trial (COVAIL Trial)
ClinicalTrials.gov study NCT05289037. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Immunologic Responses to a Live Attenuated Oral Cholera Vaccine
ClinicalTrials.gov study NCT03251495. IPD Sharing: NO. Countries: 1. Publications: 1.
Trivalent Ganglioside Vaccine With Immunological Adjuvant or Immunological Adjuvant Alone in Metastatic Sarcoma Patients Who Are Rendered Disease Free
ClinicalTrials.gov study NCT01141491. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Rebif Advanced Magnetic Resonance Imaging (MRI) and Immunology Pilot Trial
ClinicalTrials.gov study NCT01085318. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Immunological Response After Shrimp Oral Immunotherapy Treatment
ClinicalTrials.gov study NCT04552522. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Immunological Persistence After Priming With GSK1024850A Vaccine and Safety& Immunogenicity After Booster Dose
ClinicalTrials.gov study NCT01119625. IPD Sharing: YES. Countries: 1. Publications: 1.
Combining TLR9 Agonist With bNAbs for Reservoir Reduction and Immunological Control of HIV
ClinicalTrials.gov study NCT03837756. IPD Sharing: YES. Countries: 4. Publications: 1.
Immunologic Response to Kansui in Treated HIV+ Individuals: a Dose Escalation Study
ClinicalTrials.gov study NCT02531295. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Study of Early Immunologic Response in Asian Patients With Chronic Hepatitis B, Treated With Pegasys (Peginterferon Alfa-2a (40KD)), Nucleoside Analogues, or Both
ClinicalTrials.gov study NCT00962871. IPD Sharing: Not stated. Countries: 4. Publications: 2.
A Pilot Surgical Trial To Evaluate Early Immunologic Pharmacodynamic Parameters For The PD-1 Checkpoint Inhibitor, Pembrolizumab (MK-3475), In Patients With Surgically Accessible Recurrent/Progressive
ClinicalTrials.gov study NCT02852655. IPD Sharing: NO. Countries: 1. Publications: 1.
Immunologic Effects of HCV Therapy With HARVONI in HCV Genotype 1 Chronically Mono-infected Active and Former IDUs
ClinicalTrials.gov study NCT02347345. IPD Sharing: NO. Countries: 1. Publications: 3.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.