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72 results for “insecticide resistance”
Data from: Beneficial reversal of dominance maintains a large-effect resistance polymorphism under fluctuating insecticide selection
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Data from: Evolutionary trade-offs of insecticide resistance – the fitness costs associated with target-site mutations in the nAChR of Drosophila melanogaster
<p>The evolution of resistance to drugs and pesticides poses a major threat to human health and food security. Neonicotinoids are highly effective insecticides used to control agricultural pests. They target the insect nicotinic acetylcholine receptor and mutations of the receptor that confer resistance have been slow to develop, with only one field-evolved mutation being reported to date. This is an arginine to threonine substitution at position 81 of the nAChR_β1 subunit in neonicotinoid resistant aphids. To validate the role of R81T in neonicotinoid resistance and to test whether it may confer any significant fitness costs to insects, CRISPR/Cas9 was used to introduce an analogous mutation in the genome of <i>Drosophila melanogaster</i>. Flies carrying R81T showed an increased tolerance (resistance) to neonicotinoid insecticides, accompanied by a significant reduction in fitness. In comparison, flies carrying a deletion of the whole nAChR_α<em>6</em> subunit, the target-site of spinosyns, showed an increased tolerance to this class of insecticides but presented almost no fitness deficits.</p>
Adaptation by copy number variation increases insecticide resistance in the fall armyworm (vcf files)
<p>Here, I deposite vcf files used for a paper, entitled 'Adaptation by copy number variation increases insecticide resistance in the fall armyworm'.</p> <p>genotype.vcf and SNP.filtered.vcf.gz have the information of CNVs and SNPs, respectively. </p>
Raw experiment data from: Homogeneity of agriculture landscape promotes insecticide resistance in the ground beetle Poecilus cupreus
<p>This dataset is raw research data related to the paper published in PLOS ONE: Sowa et al. 2022, Homogeneity of agriculture landscape promotes insecticide resistance in the ground beetle <em>Poecilus cupreus</em>; <a href="https://doi.org/10.1371/journal.pone.0266453">https://doi.org/10.1371/journal.pone.0266453</a></p>
Illumina RNA-Sequencing fastq data from insecticide resistant Anopheles gambiae s.l
<p>This is a dataset of Illumina RNA sequencing reads, for a project investigating resistance to Pirimiphos-methyl in the major malaria vectors, Anopheles gambiae and Anopheles coluzzii. There are four biological replicates for the following conditions:</p> <p> </p> <p>Ngousso (susceptible)</p> <p>Kisumu (susceptible)</p> <p>Bouake gambiae unexposed</p> <p>Bouake gambiae PM survivors</p> <p>Bouake coluzzii unexposed </p> <p>Bouake coluzzii PM survivors </p> <p> </p> <p>SRA submission: SUB14596876</p> <p> </p>
Fig. 1 in Monitoring field populations of Plutella xylostella (Lepidoptera: Plutellidae) for resistance to eight insecticides in China
Fig. 1. Sampling sites of Plutella xylostella field populations in seven provinces of China.
Fig. 1 in Fitness cost in field Anopheles labranchiae populations associated with resistance to the insecticide deltamethrin
Fig. 1. Geographic origin of Tunisian populations of Anopheles labranchiae.
Conserved loci and tandem arrays of P450s facilitate evolution of insecticide resistance in noctuid moths
<p><span>Noctuid moths are major agricultural pests causing extensive crop damage worldwide. Their enhanced insecticide resistance is largely attributed to expansions and variations of cytochrome P450 genes, which play a pivotal role in adapting to environmental pressures. In this study, we analyzed genomic data from eight noctuid species and four representative Lepidopteran species to explore the evolutionary patterns and functional diversification of P450s. Our results reveal substantial expansions in the CYP3 and CYP4 subfamilies in noctuids, primarily driven by gene duplications forming extensive tandem arrays. Synteny analysis identified two conserved P450 loci across all examined Lepidopteran species; notably, noctuid species exhibit significant expansions at these loci—including a 20-gene cluster in <em>Spodoptera frugiperda </em>and an 18-gene cluster in <em>S. littoralis</em>. Phylogenetic analyses indicate that these expansions are lineage-specific to noctuids. Furthermore, molecular docking of P450s from these loci with nine pesticides suggests that these gene expansions may confer resistance to pyrethroids. Our findings provide crucial insights into the molecular mechanisms underlying noctuid adaptation and resistance, with important implications for developing more sustainable pest management strategies.</span></p>
A new optical practice as an effective alternative to insecticides for controlling highly resistant thrips
<p>The documents are raw data for an article entitled "<strong>A new optical practice as an effective alternative to insecticides for controlling highly resistant thrips</strong>", including the original data of Bioassy, Megalurothrips usitatus occurrence rate, RT-qPCR, standard curves, Thrips palmi occurrence rate, and yield and fruit shape of Cowpea and Hami melon.</p>
Data from: Larval density mediates knockdown resistance to pyrethroid insecticides in adult Aedes aegypti
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Data from: Evolutionary trade-offs of insecticide resistance – the fitness costs associated with target-site mutations in the nAChR of Drosophila melanogaster
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Fitness effects for Ace insecticide resistance mutations are determined by ambient temperature
Background <p>Insect pest control programs often use periods of insecticide treatment with intermittent breaks, to prevent fixing of mutations conferring insecticide resistance. Such mutations are typically costly in an insecticide free environment, and their frequency is determined by the balance between insecticide treatment and cost of resistance. Ace, a key gene in neuronal signaling, is a prominent target of many insecticides and across several species three amino acid replacements (I161V, G265A and F330Y) provide resistance against several insecticides. Because temperature disturbs neuronal signaling homeostasis, we reasoned that the cost of insecticide resistance could be modulated by ambient temperature.</p> Results <p>Experimental evolution of a natural Drosophila simulans population at hot and cold temperature regimes uncovered a surprisingly strong effect of ambient temperature. In the cold temperature regime, the resistance mutations were strongly counter selected (s= -0.055), but in a hot environment the fitness costs of resistance mutations were reduced by almost 50% (s=-0.031). We attribute this unexpected observation to the advantage of the reduced enzymatic activity of resistance mutations in hot environments.</p> Conclusion <p>We show that fitness costs of insecticide resistance genes are temperature-dependent, and suggest that duration of insecticide-free periods need to be adjusted for different climatic regions to reflect these costs. We suggest that such environment-dependent fitness effects may be more common than previously assumed and pose a major challenge for modeling climate change.</p>
Data from: Bionomics and insecticide resistance of the arboviral vector Aedes albopictus in northern Lao PDR
In the last four decades there has been a staggering increase in the geographical range of the arboviral vector Aedes albopictus (Skuse, 1894). This species is now found in every continent except Antarctica, increasing the distribution of arboviral diseases such as dengue and chikungunya. In Lao PDR dengue epidemics occur regularly, with cases of chikungunya also reported. As treatment methods for arboviral diseases is limited, the control of the vector mosquitoes are essential. There is a paucity of information on the bionomics and resistance status of this mosquito for successful vector control efforts. Here we describe the bionomics and insecticide resistance status of Ae. albopictus in Laos to identify opportunities for control. Adult Ae. albopictus were collected using human-baited double bed net (HDN) traps in forests, villages and rubber plantations and tested for alpha- and flaviviruses with RT-PCR. Surveys were also conducted to identify larval habitats. Seven adult and larval populations originating from Vientiane Capital and Luang Prabang province were tested against DDT, malathion, permethrin, deltamethrin and, temephos following WHO protocols. Aedes albopictus were found throughout the year, but were six-fold greater in the rainy season than the dry season. Adult females were active for 24 hours, with peak of behaviour at 18.00 h. The secondary forest and rubber plantation samples showed evidence of Pan-flaviviruses, while samples from the villages did not. More than half of the emerged Ae. albopictus were collected from mature rubber plantations (53.9%; 1,533/2,845). Most Ae. albopictus mosquitoes emerged from latex collection cups (19.7%; 562/2,845), small water containers (19.7%; 562/2,845) and tyres (17.4%; 495/2,845). Adult mosquitoes were susceptible to pyrethroids, apart from one population in Vientiane city. All populations were resistant to DDT (between 27–90% mortality) and all except one were resistant to malathion (20–86%). Three of the seven larval populations were resistant to temephos (42–87%), with suspected resistance found in three other populations (92–98%).This study demonstrates that rural areas in northern Laos are potential hot spots for arboviral disease transmission. Multiple-insecticide resistance was found. Aedes albopictus control efforts in villages need to expand to include secondary forests and rubber plantations, with larval source management and limited use of insecticides.
Data from: Analysis-ready datasets for insecticide resistance phenotype and genotype frequency in African malaria vectors
The impact of insecticide resistance in malaria vectors is poorly understood and quantified. Here a series of geospatial datasets for insecticide resistance in malaria vectors are provided so that trends in resistance in time and space can be quantified and the impact of resistance found in wild populations on malaria transmission in Africa can be assessed. Data are also provided for common genetic markers of resistance to support analyses of whether these genetic data can improve the ability to monitor resistance in low resource settings. Specifically, data have been collated and geopositioned for the prevalence of insecticide resistance, as measured by standard bioassays, in representative samples of individual species or species complexes. Data are provided for the Anopheles gambiae species complex, the Anopheles funestus subgroup, and for nine individual vector species. In addition, allele frequencies for known resistance associated markers in the Voltage-gated sodium channel (Vgsc) are provided. In total, eight analysis-ready, standardised, geopositioned datasets encompassing over 20,000 African mosquito collections between 1957 and 2017 are provided.
Impact of Insecticide Resistance on Vector Control
ClinicalTrials.gov study NCT01713517. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effectiveness Study of New Generation Bednets in the Context of Conventional Insecticide Resistance in the Democratic Republic of the Congo
ClinicalTrials.gov study NCT03289663. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Insecticide Resistance Management in Burkina Faso and Côte D'Ivoire
ClinicalTrials.gov study NCT03074435. IPD Sharing: UNDECIDED. Countries: 2. Publications: 9.
Efficacy of Two Dual Active Ingredient Long Lasting Insecticidal Nets for Control of Malaria Transmitted by Pyrethroid Resistant Vectors in Benin
ClinicalTrials.gov study NCT03931473. IPD Sharing: NO. Countries: 1. Publications: 7.
Genome assembly and population sequencing reveal three populations and signatures of insecticide resistance of Tuta absoluta in Latin America
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Data from: Bionomics and insecticide resistance of the arboviral vector Aedes albopictus in northern Lao PDR
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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