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Dataset results
269 results for “integrins”
Flow Cytometry Data files for Settle et al. Nature Communications, B2 integrins impose a mechanical checkpoint on macrophage phagocytosis
<p>FCS Data files for all flow cytometry results for Settle et al, B2 integrins impose a mechanical checkpoint on macrophage phagocytosis, to be published in Nature Communications. </p>
Dataset to "Collagen I Increases Palmitate-Induced Lipotoxicity in HepG2 Cells via Integrin-Mediated Death"
Open the record for dataset details and reuse information.
Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters, data part 6
<p>Part 6 of data for the article Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters.</p>
Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters, data part 4
<p>Part 4 of data for the article Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters.</p>
Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters, data part 3
<p>Part 3 of data for the article <em>Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters.</em></p>
Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters, data part 5
<p>Part 5 of data for the article Giant worm-shaped ESCRT-scaffolds surround actin-independent integrin clusters.</p>
PAML data set for integrins, tetraspanins, and ADAMs in the coral Acropora
<p>Data set for gamete composing integrins, tetraspanins, and ADAMs in the coral <em>Acropora digitifera</em>. The LC-MS/MS analyses of eggs or sperm of the coral <em>Acropora digitifera</em> were conducted. Identified integrins, tetraspanins, and ADAMs which are reported in their involvement in the fertilization of the coral <em>Acropora</em>. The data sets were used for analyses of molecular evolutionary analyses with codeml to select which genes encoding the proteins showed accelerated evolution during acquisition of species-specific fertilization. cDNA sequences of the identified proteins were used for collecting the orthologues of the <em>Acropora</em> spp using Orthoscope.</p>
Repository for 'Surface-induced phase separation of reconstituted nascent integrin clusters on lipid membranes'
<p>Surface-induced phase separation of reconstituted nascent integrin clusters on lipid membranes (PNAS)</p> <p>The structure of this repository is as follows:</p> <p>1. FRAP_curves.zip -- contains FRAP curves </p> <ul> <li>FRAP_curves_for_fig2F_figS5</li> <li>FRAP_curves_for_fig2G</li> <li>FRAP_curves_for_fig2H</li> <li>FRAP_curves_for_fig2I</li> <li>FRAP_curves_for_fig2J</li> <li>FRAP_curves_for_fig2K</li> <li>FRAP_curves_for_figS8&E</li> </ul> <p>2. Images.zip -- contains confocal images epifluorescence images</p> <ul> <li>Images_for_fig1G_fig1H</li> <li>Images_for_fig3D</li> <li>Images_for_figS1</li> <li>Images_for_figS2C</li> <li>Images_for_figS3C</li> <li>Images_for_figS6</li> </ul> <p>3. Source_data.xlsx -- contains the data for plotting the Figures</p>
Eosinophil β1 Integrin Activation as a Biomarker for Eosinophilic Esophagitis
ClinicalTrials.gov study NCT02775045. IPD Sharing: YES. Countries: 1. Publications: 1.
Detection of Integrin avb6 in IPF, PSC, and COVID19 Using PET/CT
ClinicalTrials.gov study NCT03183570. IPD Sharing: NO. Countries: 1. Publications: 1.
Dual SSTR2 and Integrin αvβ3 Targeting PET/CT Imaging
ClinicalTrials.gov study NCT02817945. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Integrin αvβ6-targeted PET in Malignant Tumors
ClinicalTrials.gov study NCT05835570. IPD Sharing: NO. Countries: 1. Publications: 11.
Integrin β7, BCMA, CS1, CD38 and CD138 as the Single or Compound Targets for the Fourth Genenation of CAR-T Cells
ClinicalTrials.gov study NCT03778346. IPD Sharing: UNDECIDED. Countries: 1. Publications: 11.
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)
ClinicalTrials.gov study NCT06167590. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Integrin Alpha-v-Beta and [18F]-R01-MG-F2 PET/CT in Measuring Response in Patients With Pancreatic Cancer and Healthy Volunteers
ClinicalTrials.gov study NCT02683824. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The integrin-mediated adhesive complex in the ancestor of animals, fungi, and amoebae
Open the record for dataset details and reuse information.
Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation
<p><span><span><span><span><span><span><span><span><span><span><span>Integrin adhesion complexes (IACs) are integrin-based plasma membrane-associated compartments where cells sense environmental cues. The physical mechanisms and molecular interactions that mediate initial IAC formation are unclear. We found that both p130Cas ("Cas") and Focal adhesion kinase ("FAK") undergo liquid-liquid phase separation <i>in vitro</i>under physiologic conditions. Cas- and FAK- driven phase separation is sufficient to reconstitute kindlin-dependent integrin clustering <i>in vitro </i>with recombinant mammalian proteins. <i>In vitro</i> condensates and IACs in mouse embryonic fibroblasts (MEFs) exhibit similar sensitivities to environmental perturbations including changes in temperature and pH. Furthermore, mutations that inhibit or enhance phase separation <i>in vitro</i> reduce or increase the number of IACs in MEFs, respectively. Finally, we find that the Cas and FAK pathways act synergistically to promote phase separation, integrin clustering, IAC formation and partitioning of key components <i>in vitro</i> and in cells. We propose that Cas- and FAK- driven phase separation provides an intracellular trigger for integrin clustering and nascent IAC formation.</span></span></span></span></span></span></span></span></span></span></span></p>
Increased spatial coupling of integrin and collagen IV in the immunoresistant clear-cell renal-cell carcinoma tumor microenvironment - Validation mIF
<p>mIF object from <em>spatialTIME</em> R package, calculating univariate Ripley's K on multiplex immunofluorescence images stained with FOXP3, CD8, CD68, ITGAV, COL4, VIM, SMA, and PCK. Data was processed with InForm and HALO. </p> <p>Clear cell renal cell carcinoma and papillary renal cell carcinoma were profiled before and after exposure to immunotherapy, with and without sarcomatoid features in clear cell tumors. Each tumor had a field of view in the stromal compartment and field of view in the tumor compartment.</p> <p>For appropriate clinical information associated with this study, please contact Dr. Brandon Manley.</p>
Phosphorylation Regulation Mechanism of β2 Integrin for the Binding of Filamin Revealed by Markov State Model
<p>Datasets of MD and MSM trajectories</p>
Data from: MFAP5 contributes to inflammation, synovial hyperplasia and joint damage in rheumatoid arthritis via integrin-ERK signaling
<p>Synovial hyperplasia is the primary pathological changes of RA and FLS is the principal etiological cellular component that drives and constitutes the pathological lesions. To elucidate the molecular mechanism of how FLS may contribute to RA, we performed transcriptome profiling to determine the DEGs between normal and RA FLS. We compared the primary FLS isolated from healthy control (HFLS) to that isolated from RA patients (RA FLS), and also to an immortalized RA FLS cell line MH7A immortalized by stably transfecting primary RA FLS cells with SV40 T antigen gene. </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.