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40
datasets available to search
ShareScore release 0.9.0
Dataset results
40 results for “internal genes”
Time- and dose rate-related effects of internal 177Lu exposure on gene expression in mouse kidney tissue
GEO Series GSE53164. Mus musculus. 72 samples. Type: Expression profiling by array.
Gene expression profiling of RPMI-grown and macrophage-internalized Candida glabrata wild-type, Cgrsc3-a∆ and Cgrtt109∆ cells.
GEO Series GSE38953. Nakaseomyces glabratus; Nakaseomyces glabratus CBS 138. 16 samples. Type: Expression profiling by array.
Effect of 90Sr internal emitter on gene expression in mouse blood
GEO Series GSE64775. Mus musculus. 56 samples. Type: Expression profiling by array.
Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station
GEO Series GSE74708. Homo sapiens. 60 samples. Type: Expression profiling by array.
Gene expression changes of Streptomyces coelicolor M145 under external and internal disturbances
GEO Series GSE53563. Streptomyces coelicolor. 4 samples. Type: Expression profiling by array.
Gene expression profiling of pediatric adrenocortical tumors collected by the International Pediatric Adrenocortical Tumor Registry (IPACTR).
GEO Series GSE76021. Homo sapiens. 29 samples. Type: Expression profiling by array.
Spliced synthetic genes as internal controls in RNA sequencing experiments.
GEO Series GSE77072. Homo sapiens; synthetic construct. 10 samples. Type: Expression profiling by high throughput sequencing.
Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station
In recent times long-term stay has become a common occurrence in the International Space Station (ISS). However adaptation to the space environment can sometimes pose physiological problems to the astronauts after their return. Therefore it is important to develop healthcare technologies for astronauts. In this study hair an easy-to-obtain sample was identified as the candidate. In order to investigate the genetic changes in human hair during space flight the hair follicles of 10 astronauts were analyzed by DNA microarray and real time q-PCR analyses. Space environment induced gene expression of hair follicles of astronaut was measured 6 differnent times included 2 in flight on orbit. Ten independent experiments were performed on differing astronauts. and the sampling day was differed for each astronaut because of their schedules.
Exposure to elevated relative humidity in laboratory chambers alters fungal gene expression in dust from the International Space Station (ISS)
Microbes are present in all occupied indoor environments, including the International Space Station (ISS). An unexpected ventilation system failure may lead to microbial and fungal growth that is associated with material degradation or negative health effects. There is a need for improved understanding of fungal function when exposed to moisture in indoor spaces. A de novo metatranscriptomic study was performed using dust collected from within the ISS. After returning to Earth, dust was incubated in laboratory chambers to simulate relative humidity conditions of 50%, 85%, or 100% equilibrium relative humidity (ERH) for 1-week. Changes in fungal function (gene expression) were associated with moisture exposure. Genes associated with secondary metabolism and fungal growth were significantly upregulated (p ≤ 0.001, log2FC ≥ 2) at elevated RH conditions (85% or 100% ERH). Elevated moisture conditions showed an increased expression of mycotoxin and fungal allergen genes such as Asp f 4 and Alt a 7 (log2FC ≥ 5). These results demonstrate that understanding microbial gene expression in response to elevated moisture will help improve microbial monitoring standards for confined spacecraft environments and help protect astronaut health and spacecraft integrity.
Gene expression in blood of mice with internal exposure to Cs-137
Cesium-137 is a radionuclide of concern in fallout from reactor accidents or nuclear detonations. When ingested or inhaled it can expose the entire body for an extended period of time potentially contributing to serious health consequences ranging from acute radiation syndrome to increased cancer risks. In order to identify changes in gene expression that may be informative for detecting such exposure and to begin examining the molecular responses involved we have profiled global gene expression in mice injected with 137CsCl. We extracted RNA from the blood of control or 137CsCl-injected mice at 2 3 5 20 or 30 days after exposure. Gene expression was measured using Agilent Whole Mouse Genome Microarrays and the data was analyzed using BRB-ArrayTools. Three-month old male C57Bl/6 mice were injected intraperitoneally with 8.0 xc2 xb1 0.3 MBq 137CsCl solution in a volume of 50 xce xbcL or left as controls. Groups of treated and control mice were sacrificed at intervals during the first 2-30 days after exposure and total blood was collected using cardiac puncture. RNA was extracted from the blood globin-transcript reduced and subjected to whole genome expression microarray analysis.
Validation of Methods to Assess the Immunoglobulin Gene Repertoire in Tissues Obtained from Mice on the International Space Station
Spaceflight is known to affect immune cell populations. In particular, splenic B-cell numbers decrease during spaceflight and in ground-based physiological models. Although antibody isotype changes have been assessed during and after spaceflight, an extensive characterization of the impact of spaceflight on antibody composition has not been conducted in mice. Next Generation Sequencing and bioinformatic tools are now available to assess antibody repertoires. We can now identify immunoglobulin gene- segment usage, junctional regions, and modifications that contribute to specificity and diversity. Due to limitations on the International Space Station, alternate sample collection and storage methods must be employed. Our group compared Illumina MiSeq sequencing data from multiple sample preparation methods in normal C57Bl/6J mice to validate that sample preparation and storage would not bias the outcome of antibody repertoire characterization. In this report, we also compared sequencing techniques and a bioinformatic workflow on the data output when we assessed the IgH and Igκ variable gene usage. Our bioinformatic workflow has been optimized for Illumina HiSeq and MiSeq datasets, and is designed specifically to reduce bias, capture the most information from Ig sequences, and produce a data set that provides other data mining options.
The SinR•SlrR heteromer internally attenuates a long transcript of flagellar genes in B. subtilis [ChIP-seq]
GEO Series GSE285064. Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10. 33 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The SinR•SlrR heteromer internally attenuates a long transcript of flagellar genes in B. subtilis [RNA-seq]
GEO Series GSE285065. Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10. 10 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic and proteomic multi-model global gene expression analysis reveals regulatory signatures during ischemia stroke (photothrombotic internal ischemia stroke)
GEO Series GSE134110. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Reliable analysis of the catabolic gene landscape and transcriptome for pollutant degradation using a custom open source microarray with internal calibration
GEO Series GSE30303. Cupriavidus pinatubonensis JMP134; Rhizorhabdus wittichii RW1; unidentified microorganism; Pseudomonas putida F1; Paraburkholderia xenovorans LB400. 23 samples. Type: Expression profiling by array.
Internal reference gene selection under salt, alkali, and drought stresses in ecological remediation plant giant reed
GEO Series GSE190890. Arundo donax. 32 samples. Type: Expression profiling by RT-PCR.
Effects of internal low dose irradiation from 131I on gene expression in normal mouse tissue
GEO Series GSE32014. Mus musculus. 20 samples. Type: Expression profiling by array.
Genetics of internal heat necrosis (IHN) in potato (Solanum tuberosum) via microarray analysis of gene expression
GEO Series GSE10338. Solanum tuberosum. 16 samples. Type: Expression profiling by array.
Integration between MCL1 gene co-expression module and the Revised International Staging System enables precise prognostication and prediction of response to proteasome inhibitor-based therapy in indi
GEO Series GSE190042. Homo sapiens. 93 samples. Type: Expression profiling by array.
Gene expression radiation response in female mice after protracted external irradiation simulating internal 137Cs.
GEO Series GSE226096. Mus musculus. 80 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.