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101
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Dataset results
101 results for “lactose”
Efficacy of Lactose-free Milk in Treating Acute Gastroenteritis in Infants
ClinicalTrials.gov study NCT05634603. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Effect of Probiotic Supplementation on Lactose Maldigestion Induced by Lactose Solution
ClinicalTrials.gov study NCT03814668. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Comparison Of Outcome Of Lactose Free Formula Milk With Yogurt In Children With Acute Diarrhea
ClinicalTrials.gov study NCT04796480. IPD Sharing: NO. Countries: 1. Publications: 3.
Secondary Lactose Intolerance Due to Chronic Norovirus Infection
ClinicalTrials.gov study NCT01840891. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION)
ClinicalTrials.gov study NCT05100719. IPD Sharing: YES. Countries: 1. Publications: 31.
Lactobreath: A Study to Diagnose Lactose Intolerance Using Breath Markers
ClinicalTrials.gov study NCT06177938. IPD Sharing: YES. Countries: 1. Publications: 1.
Acid Lactase in Combination With Yoghurt Bacteria for Improvement of Lactose Digestion in Lactose Malabsorbers
ClinicalTrials.gov study NCT01593631. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Lactose on Fecal Microflora
ClinicalTrials.gov study NCT00599859. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effect of Probiotic Supplementation on Lactose Maldigestion Induced by Fat-free Milk
ClinicalTrials.gov study NCT03659747. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of A2 Milk on Gastrointestinal Function in Non-lactose Milk Intolerance
ClinicalTrials.gov study NCT03060395. IPD Sharing: NO. Countries: 1. Publications: 4.
Effects of Raw Versus Other Milk Sources on Lactose Digestion
ClinicalTrials.gov study NCT01129791. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Long-term evolution of the natural isolate of Escherichia coli 536 in the mouse gut colonized after maternal transmission reveals convergence in the constitutive expression of the lactose operon.
Open the record for dataset details and reuse information.
Lactose operon sequences from: Nature reserves suppress evolutionary rescue from extinction
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Data from: Adaptation of Escherichia coli to glucose promotes evolvability in lactose
The selective history of a population can influence its subsequent evolution, an effect known as historical contingency. We previously observed that five of six replicate populations that were evolved in a glucose-limited environment for 2,000 generations, then switched to lactose for 1,000 generations, had higher fitness increases in lactose than populations started directly from the ancestor. To test if selection in glucose systematically increased lactose evolvability, we started 12 replay populations—six from a population subsample and six from a single randomly selected clone—from each of the six glucose-evolved founder populations. These replay populations and 18 ancestral populations were evolved for 1,000 generations in a lactose-limited environment. We found that replay populations were initially slightly less fit in lactose than the ancestor, but were more evolvable, in that they increased in fitness at a faster rate and to higher levels. This result indicates that evolution in the glucose environment resulted in genetic changes that increased the potential of genotypes to adapt to lactose. Genome sequencing identified four genes—iclR, nadR, spoT and rbs—that were mutated in most glucose-evolved clones and are candidates for mediating increased evolvability. Our results demonstrate short-term selective costs during selection in one environment can lead to changes in evolvability that confer longer-term benefits.
Data from: DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content
Lactose provides an easily-digested energy source for neonate mammals, and is the primary carbohydrate in milk. Lactose is also a key component of many human food products, though compared to analyses of other milk components, the genetic control of lactose has been little studied. Here we present the first GWAS of milk lactose concentration and yield, investigated in a population of 12,000 taurine dairy cattle. We detail 27 QTL spanning these traits, and subsequently validate the effects of 26 of these loci in a separate population of 18,000 cows. We next present data implicating causative genes and variants for these QTL. Fine mapping of these regions using imputed, whole genome sequence-resolution genotypes reveals protein-coding candidate causative variants affecting the ABCG2, DGAT1, STAT5B, KCNH4, NPFFR2 and RNF214 genes. Eleven of the remaining QTL appear to be driven by regulatory effects, suggested by the presence of co-locating, co-segregating eQTL discovered using mammary RNA sequence data representing a population of 357 lactating cows. Pathway analysis of genes representing all lactose-associated loci shows significant enrichment of genes located to the endoplasmic reticulum, with functions related to ion channel activity mediated through the LRRC8C, P2RX4, KCNJ2 and ANKH genes. Together, these findings highlight novel candidate genes and variants involved in milk lactose regulation, whose impacts on facilitated and active membrane transport mechanisms reinforce the key osmo-regulatory roles of lactose in milk.
Effect of Lactose on Blood Lipids
ClinicalTrials.gov study NCT04924530. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of B.Bifidum 900791 Intake in Adult With Hypolactasia and Lactose Intolerance
ClinicalTrials.gov study NCT03952988. IPD Sharing: NO. Countries: 0. Publications: 7.
HYBRID: Hydrogen Breath Test in Lactose Digestion
ClinicalTrials.gov study NCT02703987. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Testing the Capability of the Smart Underwear Device to Detect Increased Microbiome Activity Following Lactose Consumption
ClinicalTrials.gov study NCT06724705. IPD Sharing: YES. Countries: 1. Publications: 0.
Incidence of Lactose Intolerance Among Self-reported Lactose Intolerant People
ClinicalTrials.gov study NCT02878876. IPD Sharing: NO. Countries: 0. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.