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Dataset results
165 results for “late life”
Augmenting Antidepressant Treatment With Interpersonal Psychotherapy for Treating Late-life Depression
ClinicalTrials.gov study NCT00177294. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Social Connections and Late Life Suicide
ClinicalTrials.gov study NCT02188485. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Buprenorphine for Late-Life Treatment Resistant Depression
ClinicalTrials.gov study NCT01071538. IPD Sharing: NO. Countries: 1. Publications: 5.
Incomplete Response in Late Life Depression: Getting to Remission (IRL GREY)
ClinicalTrials.gov study NCT00892047. IPD Sharing: Not stated. Countries: 2. Publications: 17.
Stress and Inflammation in Late-Life Depression
ClinicalTrials.gov study NCT02389465. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Antidepressant Medication Plus Donepezil for Treating Late-life Depression
ClinicalTrials.gov study NCT00177671. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Ketamine for Treatment Resistant Late-Life Depression
ClinicalTrials.gov study NCT02556606. IPD Sharing: NO. Countries: 1. Publications: 1.
A Pilot fMRI Study of TMS in Late-Life Severe Worry
ClinicalTrials.gov study NCT03577106. IPD Sharing: NO. Countries: 1. Publications: 4.
Valproate in Late Life Schizophrenia
ClinicalTrials.gov study NCT00194025. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Brain Imaging Biomarkers of Pathological Brain Aging in Late-life Depression
ClinicalTrials.gov study NCT03849417. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Preventing Depression in Late Life: A Model for Low and Middle Income Countries
ClinicalTrials.gov study NCT02145429. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Trait-dependent associations between early- and late-life reproduction in a wild mammal
Open the record for dataset details and reuse information.
Early, typical, and late talkers: an exploratory study on predictors of language development in the first two years of life
Open the record for dataset details and reuse information.
Late-life reproduction in an insect: terminal investment, reproductive restraint or senescence
<p>1. The Terminal Investment, Reproductive Restraint or Senescence theories may explain individual late-life patterns of reproduction. The terminal investment hypothesis predicts that individuals increase reproductive allocation late in life as prospects for future survival decrease. The other two hypotheses predict reduced reproduction late in life, but for different reasons. Under the Reproductive Restraint hypothesis, individuals restrain their reproductive effort to sustain future survival and gain more time for reproducing, whereas under the Senescence process, reproduction is constrained because of somatic deterioration. While these hypotheses imply that reproduction is costly, they should have contrasted implications in terms of survival after late reproduction and somatic maintenance.</p> <p>2. Testing these hypotheses requires proper consideration of the effects of age-dependent reproductive effort on post-reproduction survival and age-related somatic functions. We experimentally tested these three hypotheses in females of the mealworm beetle, Tenebrio molitor, an iteroparous and income breeder insect. We manipulated their age-specific allocation into reproduction and observed the effects of this manipulation on their late life- fecundity, post-reproduction survival and immunocompetence as a measurement of somatic protection.</p> <p>3. We found that females exhibit age-related declines in fecundity and that this reproductive senescence is accelerated by a cost of early reproduction. The cost of reproduction had no significant effect on female longevity and their ability to survive a bacterial infection, despite that some immune cells were depleted by reproduction. We found that female post-infection survival deteriorated with age, which could be partly explained by a decline in some immune parameters. Importantly, females did not increase their reproductive effort late in life at the expense of their late-life post-reproduction survival.</p> <p>4. Late-life reproduction in T. molitor females is senescing and not consistent with a terminal investment strategy. Rather, our results suggest that females allocate resources according to a priority scheme favouring longevity at the expense of reproduction, which is in line with the reproductive restraint hypothesis.</p> <p>5. Such a priority scheme also shows that a relatively short-lived insect can evolve life history strategies hitherto known only in long-lived animals. This puts in perspective the role of longevity in the evolution of life history strategies. </p>
Data from: Marine life in a greenhouse world: cephalopod biodiversity and biogeography during the early Late Cretaceous
Two end-member models are proposed to explain marine biotic responses to greenhouse conditions. Global warming and increasing sea level may: (1) promote dispersal of marine species, leading to larger geographic ranges and decreased speciation and biodiversity, or (2) form isolated epicontinental basins that host endemic radiations, leading to smaller geographic ranges and increased speciation and biodiversity. The Cenomanian–Turonian (C–T) interval, marked by greenhouse warming, sea level rise, ocean anoxia, and biotic turnover, presents an opportunity to test these two end-member models. In particular, how cephalopods responded to these global changes has not been clear. A global database of 7,262 cephalopod occurrences was used to evaluate biodiversity changes through the C–T interval. Both species- and genus-level diversity peaked in the Late Cenomanian. The global diversity drop across the C/T boundary was modest; rather, diversity was low during the Middle Cenomanian and Middle Turonian, times of brief cooling. Regional variations in diversity responses may reflect the degree and timing of environmental perturbations within different oceanographic settings. Surprisingly, cephalopod faunas in the European Platform, Western Interior, and South Atlantic all shifted equatorward across the C/T boundary, whereas other regions saw no change in latitudinal distributions. Global generic geographic ranges did not change through the C–T interval, but the percentage of cosmopolitan genera did increase significantly across the C/T, both globally and within the Western Interior and Europe, whereas cosmopolitans dropped in the Pacific and South Atlantic. Neither end-member model for biodiversity change in a greenhouse world is supported for C–T cephalopods, as diversity increased without an associated increase in geographic range. It may be that sea level rise and global warming led to both endemic radiations in epicontinental basins and an increase in cosmopolitan taxa in some regions, demonstrating the importance of combining global and regional scale analyses.
Figure 2 in Bone histology of the Late Pleistocene Prolagus sardus (Lagomorpha: Mammalia) provides further insights into life-history strategy of insular giant small mammals
Figure 2. Bone histology of Ochotona specimens. A–C, Oc. dauurica. A, MSB 215940 (juvenile) showing a cortex formed by FLC and WB. B, MSB 215680 (young adult), with abundant SVs in the outer cortex. Note that microorganisms attacked this region, hiding bone tissues. C, MSB 215953 (adult) with FLC sandwiched between ICL and a scarce LB layer. Note the strong RL (black arrowhead). D, Oc. collaris UAM 63937 (adult), with an extensive deposition of PFB and clear RL (black arrowhead) splitting it from FLC. Notice the presence of one LAG (white arrowhead). E, F, Oc. princeps. E, UAM 35060 (adult), anterior region with PFB surrounded by a FLC full of SOs. F, UAM 113936 (adult), with detail of the PFB region, showing four LAGs (white arrowheads). For abbreviations, see the text. Scale bars equals 100 μm.
Figure 1 in Bone histology of the Late Pleistocene Prolagus sardus (Lagomorpha: Mammalia) provides further insights into life-history strategy of insular giant small mammals
Figure 1. Bone histology of P. sardus specimens. A, B, R129 (juvenile, 0 LAG) showing the anterior region (A) formed by FLC with SVs and POs, and posterior one (B) where a nonCGM was identified (arrowhead). C, GD52 (juvenile, 0 LAG), medial region showing early external deposition of PFB with some SVs. In the inner cortex, WB is visible, as well as FLC with POs and SVs. D, R000 (juvenile, one LAG), posterior region with FLC sandwiched between the ICL and the outer cortex of LB (reversed image). E, R136 (young adult) showing two LAGs (arrowheads). F, A17 (young adult) with three LAGs (arrowheads). G, R30 (juvenile, two LAGs), detail of the lateral region with SOs
Figure 3. A–F in Bone histology of the Late Pleistocene Prolagus sardus (Lagomorpha: Mammalia) provides further insights into life-history strategy of insular giant small mammals
Figure 3. A–F, boxplots of log-transformed geometrical (CA, MA, CA/MA, and CA/TA) and size variables (DAPm and DTm). A–C, Prolagus sardus age categories (J, Y, and A). D–F, adults of Oc. princeps, Oc. collaris, and Oc. dauurica. See Supporting Information, Table S2 for the raw data, including mean and standard deviation for species and age category. G–I, growth trajectories of CA, MA, and TA, considering DTm (size proxy), of P. sardus (N = 15) and Ochotona (N = 13). See Supporting Information, Appendix S1 for statistical results.
Health-related Quality of Life and Late Effects Among SURVivors of Cancer in Adolescence and Young Adulthood: The SURVAYA Study
ClinicalTrials.gov study NCT05379387. IPD Sharing: YES. Countries: 1. Publications: 2.
Emotion-Focused Mindfulness Therapy: A Feasibility Study for Late Life Anxiety
ClinicalTrials.gov study NCT04415528. IPD Sharing: NO. Countries: 1. Publications: 6.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.