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219 results for “leishmaniasis”
Table 1 in Leishmaniasis and phlebotomine sand flies in Oman Sultanate
<p><b>Table 1.</b> Details about the places where sandflies, patients, dogs and fox have been sampled.</p><table><tbody><tr><th>Symbol</th><th>Collection</th><th>Location</th><th>Latitude</th><th>Longitude</th><th>Altitude</th><th>Number</th><th>Number</th><th>Number</th><th>Number of</th><th>Number of</th><th>Number</th></tr></tbody><tbody><tr><th>(Fig. 1)</th><td></td><td></td><td></td><td></td><td></td><td>of</td><td>of CDC</td><td>of patients</td><td><i>Leishmania</i></td><td>dogs</td><td>of fox</td></tr><tr><th></th><td></td><td></td><td></td><td></td><td></td><td></td><td>traps</td><td>examinated</td><td>strains</td><td>examinated</td><td>examinated</td></tr><tr><th></th><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>isolated</td><td></td><td></td></tr><tr><th>Sh1</th><td>Sandflies</td><td>El Kederi farm</td><td>22 <i>°</i> 47 N</td><td>58 <i>°</i> 41 E</td><td>450</td><td>33</td><td>4</td><td></td><td></td><td></td><td></td></tr><tr><th></th><td></td><td>Batem</td><td>22 <i>°</i> 49 N</td><td>58 <i>°</i> 41 E</td><td>400</td><td>20</td><td>1</td><td></td><td></td><td></td><td></td></tr><tr><th>Sh2</th><td>Sandflies</td><td>Hedna</td><td>22 <i>°</i> 37 N</td><td>59 <i>°</i> 06 E</td><td>400</td><td>31</td><td>4</td><td></td><td></td><td></td><td></td></tr><tr><th></th><td></td><td>Ouali gorges</td><td>22 <i>°</i> 36 N</td><td>59 <i>°</i> 05 E</td><td>600</td><td>101</td><td></td><td></td><td></td><td></td><td></td></tr><tr><th></th><td></td><td>Ouali Mouqual</td><td>22 <i>°</i> 36 N</td><td>59 <i>°</i> 05 E</td><td>550</td><td>188</td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>Sh3</th><td>Sandflies,</td><td>Al Rawdah</td><td>22 <i>°</i> 53 N</td><td>58 <i>°</i> 13 E</td><td>600</td><td>67</td><td>3</td><td>1</td><td>1</td><td></td><td></td></tr><tr><th></th><td>patient</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>Sh4</th><td>Sandflies, dogs</td><td>Al Khanatar</td><td>22 <i>°</i> 42 N</td><td>58 <i>°</i> 32 E</td><td>400</td><td>87</td><td>5</td><td></td><td></td><td></td><td></td></tr><tr><th></th><td></td><td>Ibra</td><td>22 <i>°</i> 43 N</td><td>58 <i>°</i> 31 E</td><td></td><td></td><td></td><td></td><td></td><td>9</td><td></td></tr><tr><th>Mascate</th><td>Patients, dogs</td><td>Muscat</td><td>23 <i>°</i> 32 N</td><td>58 <i>°</i> 24 E</td><td></td><td></td><td></td><td>1</td><td>1</td><td>4</td><td></td></tr><tr><th>School</th><td>Patients, dogs</td><td>Kafaifa school</td><td>22 <i>°</i> 53 N</td><td>58 <i>°</i> 25 E</td><td></td><td></td><td></td><td>238</td><td>0</td><td></td><td></td></tr><tr><th>Dh2</th><td>Sandflies</td><td>Djebel Al Qamar,</td><td>16 <i>°</i> 55 N</td><td>53 <i>°</i> 44 E</td><td>20</td><td>24</td><td></td><td></td><td></td><td></td><td></td></tr><tr><th></th><td></td><td>rocks</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th></th><td></td><td>Rocks</td><td>16 <i>°</i> 89 N</td><td>53 <i>°</i> 70 E</td><td>300</td><td>11</td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>Dh3</th><td>Sandflies,</td><td>Djebel Qara, farm</td><td>17 <i>°</i> 08 N</td><td>54 <i>°</i> 00 E</td><td>600</td><td>23</td><td>3</td><td>1</td><td>1</td><td></td><td></td></tr><tr><th></th><td>patient</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th></th><td></td><td>Djebel Qara, house, farm</td><td>17 <i>°</i> 07 N</td><td>54 <i>°</i> 01 E</td><td>500</td><td>25</td><td>2</td><td></td><td></td><td></td><td></td></tr><tr><th></th><td></td><td>Djebel Qara, rocks</td><td>17 <i>°</i> 06 N</td><td>54 <i>°</i> 03 E</td><td>240</td><td>20</td><td></td><td></td><td></td><td></td><td></td></tr><tr><th></th><td></td><td>Djebel Qara, rocks</td><td>17 <i>°</i> 06 N</td><td>54 <i>°</i> 03 E</td><td>240</td><td>30</td><td></td><td></td><td></td><td></td><td></td></tr><tr><th></th><td></td><td>Djebel Qara</td><td>17 <i>°</i> 14 N</td><td>54 <i>°</i> 02 E</td><td>800</td><td></td><td>2</td><td></td><td></td><td></td><td></td></tr><tr><th>Dh5</th><td>Sandflies</td><td>Rocks</td><td>16 <i>°</i> 57 N</td><td>53 <i>°</i> 19 E</td><td>800</td><td>35</td><td></td><td></td><td></td><td></td><td></td></tr><tr><th></th><td></td><td>Jejouel, village</td><td>16 <i>°</i> 58 N</td><td>53 <i>°</i> 13 E</td><td>800</td><td>25</td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>Dh6</th><td>Sandflies, fox</td><td>Ouadi Herwouib,</td><td>17 <i>°</i> 05 N</td><td>52 <i>°</i> 59 E</td><td>600</td><td>61</td><td>5</td><td></td><td></td><td></td><td></td></tr><tr><th></th><td></td><td>animal shelter</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th></th><td></td><td>Ouadi Herwouib, rocks</td><td>17 <i>°</i> 04 N</td><td>52 <i>°</i> 59 E</td><td>600</td><td>34</td><td></td><td></td><td></td><td></td><td>1</td></tr><tr><th>Total</th><td></td><td></td><td></td><td></td><td></td><td>815</td><td>29</td><td>241</td><td>3</td><td>13</td><td>1</td></tr></tbody></table>
Safety, effectiveness, and skin immune response in a controlled human infection model of sand fly transmitted cutaneous leishmaniasis.
<p>Safety, effectiveness, and skin immune response in a controlled human infection model of sand fly transmitted cutaneous leishmaniasis.</p><p>Vivak Parkash1, Helen Ashwin1, Shoumit Dey1, Jovana Sadlova2, Barbora Vojtkova2, Katrien Van Bocxlaer1,3, Rebecca Wiggins1, David Thompson4 Nidhi Sharma Dey1, Charles L. Jaffe5, Eli Schwartz6, Petr Volf2, Charles J. N. Lacey1, Alison M. Layton1,3 * and Paul M. Kaye1,3 *.</p><p> </p><p>1 York Biomedical Research Institute, Hull York Medical School, University of York, York, UK</p><p>2 Department of Parasitology, Faculty of Science, Charles University, Viničná 7, Prague, Czech Republic</p><p>3 Skin Research Centre, Hull York Medical School, York, UK</p><p>4 York and Scarborough Teaching Hospitals NHS Foundation Trust, York, UK </p><p>5 Department of Microbiology and Molecular Genetics, Kuvin Center for the Study of Infectious and Tropical Diseases, IMRIC, The Hebrew University – Hadassah Medical School, Jerusalem, Israel</p><p>6 The Center for Geographic Medicine and Tropical Diseases, Chaim Sheba Medical Center, and The School of Medicine, Tel Aviv University, Israel.</p><p> </p><p>*Corresponding authors: paul.kaye@york.ac.uk and alison.layton@hyms.ac.uk</p><p> </p>
Topical Treatment of Cutaneous Leishmaniasis With WR 279,396: A Phase 2 Study in the Old World
ClinicalTrials.gov study NCT00703924. IPD Sharing: YES. Countries: 2. Publications: 1.
Efficacy and Safety of Miltefosine or Thermotherapy for Cutaneous Leishmaniasis in Colombia.
ClinicalTrials.gov study NCT00471705. IPD Sharing: NO. Countries: 1. Publications: 47.
Prophylaxis of Visceral Leishmaniasis Relapses in HIV Co-infected Patients With Pentamidine: a Cohort Study
ClinicalTrials.gov study NCT01360762. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Local Heat Therapy Versus Sodium Stibogluconate for the Treatment of Cutaneous Leishmaniasis
ClinicalTrials.gov study NCT00884377. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety, Efficacy and Pharmacokinetics (PK) Study of WR 279,396 Versus Paromomycin for Treatment of Cutaneous Leishmaniasis (Peru-PK)
ClinicalTrials.gov study NCT01032382. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase 3 Study to Evaluate WR 279,396 vs. Paromomycin Alone to Treat Cutaneous Leishmaniasis (in Tunisia)
ClinicalTrials.gov study NCT00606580. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pharmacokinetics, Safety, and Efficacy Trial of WR 279,396 (Paromomycin + Gentamicin Topical Cream) and Paromomycin Topical Cream for the Treatment of Cutaneous Leishmaniasis in Panama
ClinicalTrials.gov study NCT01083576. IPD Sharing: Not stated. Countries: 1. Publications: 1.
DNDI-6174, a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1 complex – Figures 3 and S2-8 raw data
Open the record for dataset details and reuse information.
Macrophage targeting of nitazoxanide-loaded transethosomal gel in cutaneous leishmaniasis
Open the record for dataset details and reuse information.
Land use and cover changes and sand fly (Diptera: Psychodidae) assemblages in an emerging focus of leishmaniasis
Open the record for dataset details and reuse information.
Data from: Spatial distribution of sand fly vectors and eco-epidemiology of cutaneous leishmaniasis transmission in Colombia
Background: Leishmania is transmitted by Phlebotominae insects that maintain the enzootic cycle by circulating between sylvatic and domestic mammals; humans enter the cycles as accidental hosts due to the vector's search for blood source. In Colombia, leishmaniasis is an endemic disease and 95% of all cases are cutaneous (CL), these cases have been reported in several regions of the country where the intervention of sylvatic areas by the introduction of agriculture seem to have an impact on the rearrangement of new transmission cycles. Our study aimed to update vector species distribution in the country and to analyze the relationship between vectors' distribution, climate, land use and CL prevalence. Methods: A database with geographic information was assembled, and ecological niche modeling was performed to explore the potential distribution of each of the 21 species of medical importance in Colombia, using thirteen bioclimatic variables, three topographic and three principal components derived from NDVI. Binary models for each species were obtained and related to both land use coverage, and a CL prevalence map with available epidemiological data. Finally, maps of species potential distribution were summed to define potential species richness in the country. Results: In total, 673 single records were obtained with Lutzomyia gomezi, Lutzomyia longipalpis, Psychodopygus panamensis, Psathyromyia shannoni and Pintomyia evansi the species with the highest number of records. Eighteen species had significant models, considering the area under the curve and the jackknife results: L. gomezi and P. panamensis had the widest potential distribution. All sand fly species except for Nyssomyia antunesi are mainly distributed in regions with rates of prevalence between 0.33 to 101.35 cases per 100,000 inhabitants and 76% of collection data points fall into transformed ecosystems. Discussion: Distribution ranges of sand flies with medical importance in Colombia correspond predominantly to disturbed areas, where the original land coverage is missing therefore increasing the domiciliation potential. We highlight the importance of the use of distribution maps as a tool for the development of strategies for prevention and control of diseases.
IL-32 producing CD8+ memory T cells and Tregs define the IDO1/PD-L1 niche in human cutaneous leishmaniasis skin lesions.
<p>https://github.com/NidhiSDey/leish-ME/</p> <p>Human cutaneous leishmaniasis (CL) is characterised by chronic skin pathology. Experimental and clinical data suggest that immune checkpoints (ICs) play a crucial role in disease outcome but the cellular and molecular niches that facilitate IC expression during leishmaniasis are ill-defined. We previously showed that in Sri Lankan patients with CL two ICs, indoleamine 2,3-dioxygenase 1 (IDO1) and programmed death-ligand 1 (PD-L1) are enriched in lesional skin and that reduced PD-L1 expression early after treatment onset predicts cure rate following antimonial therapy. Here, we use spatial cell interaction mapping to identify IL-32-expressing CD8+ memory cells and regulatory T cells as key components of the IDO1 / PD-L1 niche in a cohort of Sri Lankan CL patients. This finding was confirmed in patients with distinct forms of dermal leishmaniasis in Brazil and India. Furthermore, in our Sri Lankan cohort the abundance of IL-32+ cells and IL-32+CD8+ T cells at treatment onset was prognostic for rate of cure. This study provides a unique spatial perspective on the expression of key ICs in these important skin diseases and a novel route to identify biomarkers of treatment response.</p>
Feasibility and Usability of Mobile Applications for Monitoring Cutaneous Leishmaniasis Treatment in Colombia
ClinicalTrials.gov study NCT05533736. IPD Sharing: NO. Countries: 1. Publications: 7.
Study to Evaluate the Leish-111F + MPL-SE Vaccine in the Treatment of Mucosal Leishmaniasis
ClinicalTrials.gov study NCT00111514. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pilot Study: Miltefosine Gel (G-MTF) in Patients With Cutaneous Leishmaniasis
ClinicalTrials.gov study NCT07149753. IPD Sharing: NO. Countries: 1. Publications: 6.
Topical 3% Amphotericin B Cream for the Treatment of Cutaneous Leishmaniasis in Colombia
ClinicalTrials.gov study NCT01845727. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cutaneous Leishmaniasis Diagnostic Study
ClinicalTrials.gov study NCT03837431. IPD Sharing: YES. Countries: 1. Publications: 1.
Low Antimonial Dosage in American Mucosal Leishmaniasis
ClinicalTrials.gov study NCT01301937. IPD Sharing: NO. Countries: 1. Publications: 18.
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