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52 results for “lipid nanoparticles”
Allergen-specific mRNA-lipid nanoparticle therapy for prevention and treatment of experimental allergy in mice
GEO Series GSE259439. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Lipid Nanoparticle-Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth
GEO Series GSE93832. Homo sapiens. 16 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing.
Lipid Nanoparticles Allow Efficient and Harmless Ex Vivo Gene Editing of Human Hematopoietic Cells
GEO Series GSE216250. Homo sapiens. 245 samples. Type: Expression profiling by high throughput sequencing.
Delivery of A4GALT targeting siRNA-lipid nanoparticle rescues fabry disease phenotypes in hiPSC derived endothelial cell and podocyte models
GEO Series GSE282204. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Plasmid DNA or mRNA formulated in lipid nanoparticles drive unique innate immune activation to promote adaptive immunity
GEO Series GSE271745. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
The mRNA-LNP platform’s lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory
GEO Series GSE167521. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways
GEO Series GSE279232. Mus musculus. 27 samples. Type: Expression profiling by high throughput sequencing; Other.
Low-inflammatory lipid nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 high-pathogenicity avian influenza virus with reduced adverse reactions (using dendritic cell of lymph n
GEO Series GSE279744. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Lipid Nanoparticles Allow Efficient and Harmless Ex Vivo Gene Editing of Human Hematopoietic Cells [NHEJ]
GEO Series GSE245626. Homo sapiens. 176 samples. Type: Other.
Total RNA expression in extracellular vesicles (EVs) derived from untreated and lipid nanoparticle(LNP) treated cells: lung epithelial, umbilical vein endothelial, and cardiac progenitor cells
GEO Series GSE198486. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
The saponin monophosphoryl lipid A nanoparticle adjuvant induces dose-dependent HIV vaccine responses in non-human primates
GEO Series GSE291681. Macaca mulatta. 9 samples. Type: Expression profiling by high throughput sequencing.
Data from: Energy landscape for the insertion of amphiphilic nanoparticles into lipid membranes: a computational study
Amphiphilic, monolayer-protected gold nanoparticles (NPs) have been shown to enter cells via a non-endocytic, non-disruptive pathway that could be valuable for biomedical applications. The same NPs were also found to insert into a series of model cell membranes as a precursor to cellular uptake, but the insertion mechanism remains unclear. Previous simulations have demonstrated that an amphiphilic NP can insert into a single leaflet of a planar lipid bilayer, but in this configuration all charged end groups are localized to one side of the bilayer and it is unknown if further insertion is thermodynamically favorable. Here, we use atomistic molecular dynamics simulations to show that an amphiphilic NP can reach the bilayer midplane non-disruptively if charged ligands iteratively ``flip'' across the bilayer. Ligand flipping is a favorable process that relaxes bilayer curvature, decreases the nonpolar solvent-accessible surface area of the NP monolayer, and increases attractive ligand-lipid electrostatic interactions. Analysis of end group hydration further indicates that iterative ligand flipping can occur on experimentally relevant timescales. Supported by these results, we present a complete energy landscape for the non-disruptive insertion of amphiphilic NPs into lipid bilayers. These findings will help guide the design of NPs to enhance bilayer insertion and non-endocytic cellular uptake, and also provide physical insight into a possible pathway for the translocation of charged biomacromolecules.
Clinical Trial to Evaluate the Safety and Immunogenicity of Ferritin Nanoparticles Expressing Native-like HIV-1 Envelope Trimers Followed by Boost With mRNA Lipid Nanoparticles Encoding a Native-like
ClinicalTrials.gov study NCT05903339. IPD Sharing: NO. Countries: 1. Publications: 0.
Patisiran-Lipid Nanoparticle (LNP) Pregnancy Surveillance Program
ClinicalTrials.gov study NCT05040373. IPD Sharing: NO. Countries: 7. Publications: 0.
Clinical Assessment of Oxiconazole Nitrate Solid Lipid Nanoparticles Loaded Gel
ClinicalTrials.gov study NCT03823040. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Single-Center, Open-Label, Single Ascending Dose Study of Exenatide Circular RNA-Lipid Nanoparticle Injection (CR059) in Chinese Subjects With Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT07347080. IPD Sharing: YES. Countries: 0. Publications: 0.
Lipid nanoparticles as adjuvant of Norovirus VLP vaccine augment cellular and humoral immune responses in a TLR 9- and type I IFN-dependent pathway
GEO Series GSE279372. Mus musculus. 28 samples. Type: Expression profiling by high throughput sequencing.
Low-inflammatory lipid nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 high-pathogenicity avian influenza virus with reduced adverse reactions (using whole lymph node)
GEO Series GSE279743. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Data from: Energy landscape for the insertion of amphiphilic nanoparticles into lipid membranes: a computational study
Open the record for dataset details and reuse information.
Mycolic acid nanoparticle vaccination leads to lipid antigen persistence and unique differentiation of mycobacterial-specific T cells
GEO Series GSE226075. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.