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Dataset results
237 results for “mechanism of action”
Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate
Open the record for dataset details and reuse information.
COVID-CDR: An integrative resource for network-based investigation of COVID-19 combinatorial drug repositioning and mechanism of action
Open the record for dataset details and reuse information.
An action potential initiation mechanism in distal axons for the control of dopamine release
<p>Data table for An action potential initiation mechanism in distal axons for the control of dopamine release</p>
Data table for an action potential initiation mechanism in distal axons for the control of dopamine release
<p>Data table for the article: An action potential initiation mechanism in distal axons for the control of dopamine release</p>
Source Data For: "Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel Piezo2"
<p>Source Data For: "Focused ultrasound excites action potentials in mammalian peripheral neurons in part through the mechanically gated ion channel Piezo2"</p>
High-Speed Atomic Force Microscopy Highlights New Molecular Mechanism of Daptomycin Action
<p>Data underlying the figures in the publication “High-speed atomic force microscopy highlights new molecular mechanism of daptomycin action”, published in <em>Nat Commun, </em><strong>2020</strong>, 11, 6312. <a href="https://doi.org/10.1038/s41467-020-19710-z">https://doi.org/10.1038/s41467-020-19710-z</a></p> <p>Table of contents:</p> <p><strong>1.</strong> <strong>Movie 1</strong>; HS-AFM movie of the first minutes after exposure to sub-MIC Dap on a POPG supported membrane. Guides to the eye highlights those oligomers identifiable. Movie parameters: frame rate 33 ms; full image of 90 nm x 65 nm and 256x180 pixels; colour depth 8bit (256 values); full colour scale 4 nm.</p> <p><strong>2. </strong><strong>Movie 2</strong>; HS-AFM movie after tens of minutes after exposure to sub-MIC Dap that shows diffusing dimples on a POPG supported membrane which interact by swinging trajectories. Movie parameters: frame rate 83 ms; full image of 150nm x 150nm and 256x256 pixels; colour depth 8bit (256 values); full colour scale 4 nm.</p> <p><strong>3. </strong><strong>Movie 3</strong>; HS-AFM movie of the first minutes after exposure to over-MIC of a POPG supported membrane. A flow of material is visualized thanks to the motion of the ripples, it starts at the lm3m cubic phase (left) and ends at a tubulation (right). Movie parameters: frame rate 456 ms; full image of 400nm x 400nm and 300x300 pixels; colour depth 8bit (256 values); full colour scale 16 nm.</p> <p><strong>4. </strong><strong>Movie 4</strong>; HS-AFM movie of the cyclic accumulation of material in the pores created on TOCL/POPG supported membranes under the exposure of the outer leaflet to supplementary quantities of Dap added to the imaging solution. The process seems to eject material out of the membrane; see the material that appears next to the pore at 1.30s. Movie parameters: frame rate 260 ms; zoom of a full image of 140nm x 100nm and 256x180 pixels; colour 29 depth 8bit (256 values); full colour scale 3 nm.</p>
Fig. 3 in Mechanisms of action for the anti-obesogenic activities of phytochemicals
Fig. 3. Differentiation of white, brown, and beige adipocytes. Plant products (Extracts and specific phytochemicals) inhibit white adipogenesis and activate brown adipogenesis. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2 in Mechanisms of action for the anti-obesogenic activities of phytochemicals
Fig. 2. Absorption of lipids in the body and physiological role of Pancreatic Lipase (PL). Plants products inhibit the activity of PL, thus preventing the hydrolysis of triglycerides (TGs) into monoglycerides (MGs) and free fatty acids (FFAs). Arrows indicate activation or further processing while bar indicates inhibition.
Fig. 6 in Astragalus species: Phytochemistry, biological actions and molecular mechanisms underlying their potential neuroprotective effects on neurological diseases
Fig. 6. The antiapoptotic effect of saponins in neurological diseases. They activate the PI3K/Akt survival pathway, promote the phosphorylationdependent inactivation of Bad, which leads to a decrease in caspasedependent neuronal apoptosis. Also, they maintain mitochondria integrity through modulation of p38 and mitogen-activated protein kinase (MEK) signalling pathways, which reduces the cytochrome c release and inhibits caspasedependent apoptosis (Wu et al., 2015).
Fig. 1 in Astragalus species: Phytochemistry, biological actions and molecular mechanisms underlying their potential neuroprotective effects on neurological diseases
Fig. 1. Chemical structures of the major constituents of triterpenoid saponins identified in Astragalus radix extract (Chu et al., 2010).
Fig. 5 in Astragalus species: Phytochemistry, biological actions and molecular mechanisms underlying their potential neuroprotective effects on neurological diseases
Fig. 5. Pathways through which Astragalus polysaccharides (APS) mediates anti-inflammatory effect (Zheng et al., 2020).
Fig. 3 in Astragalus species: Phytochemistry, biological actions and molecular mechanisms underlying their potential neuroprotective effects on neurological diseases
Fig. 3. Astragalus membranaceus: (A) Aerial parts, (B) Roots, (C) Root extract (Cited at https://www.cambridge.org).
Sitagliptin Mechanism of Action Study in Patients With Type 2 Diabetes Mellitus (0431-059)
ClinicalTrials.gov study NCT00704132. IPD Sharing: YES. Countries: 0. Publications: 1.
The Role of CD4+ T Cell Subsets in the Mechanism of Action of Vedolizumab in Ulcerative Colitis
ClinicalTrials.gov study NCT02721719. IPD Sharing: NO. Countries: 1. Publications: 31.
Teriflunomide's Therapeutic Mechanisms of Action in Patients With Relapsing Remitting Multiple Sclerosis.
ClinicalTrials.gov study NCT02833714. IPD Sharing: UNDECIDED. Countries: 1. Publications: 20.
Study to Investigate the Mechanism of Action of an Oral Enzyme Treatment With Bromelain, Trypsin and Rutoside Versus Placebo in Subjects With OsTeoarthritis
ClinicalTrials.gov study NCT05038410. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Depot Naltrexone Mechanism of Action in Heroin Dependent Patients Using fMRI and SPECT
ClinicalTrials.gov study NCT01471145. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Mechanism of Action of Milk and Its Components on Glycemic Control in Healthy Young Men
ClinicalTrials.gov study NCT01812967. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Mechanisms of Action on Rectal Motricity of Intrarectal Botulinum Toxin Injections
ClinicalTrials.gov study NCT05998187. IPD Sharing: NO. Countries: 1. Publications: 5.
Mechanisms of Erythropoietin Action in the Cardiorenal Syndrome
ClinicalTrials.gov study NCT00356733. IPD Sharing: Not stated. Countries: 1. Publications: 4.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.